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Journals / Turkish Journal of Chemistry / 2014 / Cilt: 38 - Sayı: 5

Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities

Yaşar DÜRÜST
Hamza KARAKUŞ
Muhsine Zeynep YAVUZ
Ali Akçahan GEPDİREMEN
Pages
739–755
Publication Date
2014-05-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:1,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-(p-substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul\-fonyl)-4,5-dihydro-1H-1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3]triazole-4,6(3aH,5H)-diones.
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Key Findings & Data:The structures of the new cycloadducts were elucidated by means of IR, NMR (1H, 13C, 2D), mass spectra, and physical characteristics (mp and Rf values).
💡
Conclusion & Impact:In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Azide · 3-dipolar cycloaddition · 4-oxadiazole

Abstract

1,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-(p-substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul\-fonyl)-4,5-dihydro-1H-1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3]triazole-4,6(3aH,5H)-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR (1H, 13C, 2D), mass spectra, and physical characteristics (mp and Rf values). In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.

Özet

1,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-((3-(p-substituted) phenyl-1,2,4-oxadiazol-5-yl)methyl)-4-(phenylsul\-fonyl)-4,5-dihydro-1H-1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3]triazole-4,6(3aH,5H)-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR (1H, 13C, 2D), mass spectra, and physical characteristics (mp and Rf values). In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.

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Cite This Article

DÜRÜST, Y., KARAKUŞ, H., YAVUZ, M. Z., GEPDİREMEN, A. A. (2014). Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities. Turkish Journal of Chemistry, Cilt: 38 - Sayı: 5, 739–755. https://ajindex.com/articles/184776

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