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Journals / Turkish Journal of Chemistry / 2013 / Cilt: 37 - Sayı: 5

Palladium-EDTA and palladium-EdteH4 catalyzed Heck coupling reactions in pure water

Süleyman GÜLCEMAL
Bekir ÇETİNKAYA
Pages
840–847
Publication Date
2013-05-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Recycling studies on the Na2PdCl4 - Na2EDTA precatalyst system are also tested in the coupling of 4-bromoacetophenone with styrene.

📌 3 Key Takeaways

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Objective & Hypothesis:Palladium-catalyzed Heck coupling reactions of styrene with bromoarene derivatives are carried out under aerobic conditions in water using water-soluble N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine (EdteH4) and ethylenediaminetetraacetic acid disodium salt (Na2EDTA) as ligands.
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Key Findings & Data:The olefination of bromoarenes with styrene affords the desired products in high yields.
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Conclusion & Impact:Recycling studies on the Na2PdCl4 - Na2EDTA precatalyst system are also tested in the coupling of 4-bromoacetophenone with styrene.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Heck coupling · palladium · Na2EDTA

Abstract

Palladium-catalyzed Heck coupling reactions of styrene with bromoarene derivatives are carried out under aerobic conditions in water using water-soluble N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine (EdteH4) and ethylenediaminetetraacetic acid disodium salt (Na2EDTA) as ligands. The effect of different bases, catalyst loading, and additives is also monitored. The olefination of bromoarenes with styrene affords the desired products in high yields. The Na2PdCl4-Na2EDTA precatalyst system is also used for the preparative scale (50.0 mmol) synthesis of 4-acetyl-trans-stilbene and 4-styrylbenzaldehyde without a noticeable decrease in the activity. Recycling studies on the Na2PdCl4 - Na2EDTA precatalyst system are also tested in the coupling of 4-bromoacetophenone with styrene.

Özet

Palladium-catalyzed Heck coupling reactions of styrene with bromoarene derivatives are carried out under aerobic conditions in water using water-soluble N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine (EdteH4) and ethylenediaminetetraacetic acid disodium salt (Na2EDTA) as ligands. The effect of different bases, catalyst loading, and additives is also monitored. The olefination of bromoarenes with styrene affords the desired products in high yields. The Na2PdCl4-Na2EDTA precatalyst system is also used for the preparative scale (50.0 mmol) synthesis of 4-acetyl-trans-stilbene and 4-styrylbenzaldehyde without a noticeable decrease in the activity. Recycling studies on the Na2PdCl4 - Na2EDTA precatalyst system are also tested in the coupling of 4-bromoacetophenone with styrene.

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Cite This Article

GÜLCEMAL, S., ÇETİNKAYA, B. (2013). Palladium-EDTA and palladium-EdteH4 catalyzed Heck coupling reactions in pure water. Turkish Journal of Chemistry, Cilt: 37 - Sayı: 5, 840–847. https://ajindex.com/articles/184754

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