The newly synthesized compounds were very efficient in terms of yield; nevertheless they did not exhibit a chiral induction.
📌 3 Key Takeaways
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Objective & Hypothesis:New furanoside-based NHC precursor salts (2) were synthesized using amino alcohols from the chloralose derivatives of glucose (a), galactose (b), and mannose (c).
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Key Findings & Data:The novel compounds were fully characterized by $^{1}$H NMR, $^{13}$C NMR, and elemental analyses.
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Conclusion & Impact:The newly synthesized compounds were very efficient in terms of yield; nevertheless they did not exhibit a chiral induction.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:N-heterocyclic carbene · carbohydrates · arylation of aldehydes
Abstract
New furanoside-based NHC precursor salts (2) were synthesized using amino alcohols from the chloralose derivatives of glucose (a), galactose (b), and mannose (c). The novel compounds were fully characterized by $^{1}$H NMR, $^{13}$C NMR, and elemental analyses. The catalytic activities of these salts were tested in the arylation of aldehydes as catalysts that were generated in situ from [RhCl(COD)]$_{2}$. In addition, 2a was converted to the rhodium complex 3a in order to compare the results obtained in situ. The newly synthesized compounds were very efficient in terms of yield; nevertheless they did not exhibit a chiral induction.
DENİZALTI, S., TELLİ, F. Ç., YILDIRAN, S., SALMAN, A. Y., ÇETİNKAYA, B. (2016). Newly synthesized furanoside-based NHC ligands for the arylation of aldehydes. Turkish Journal of Chemistry, Cilt: 40 - Sayı: 5, 689–697. https://ajindex.com/articles/184625