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Journals / Turkish Journal of Biology / 2019 / Cilt: 43 - Sayı: 4

A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells

Didem KARAKAŞ
Remzi Okan AKAR
Zeliha GÖKMEN
Nahide Gülşah DENİZ
Engin ULUKAYA
Pages
256–263
Publication Date
2019-08-02
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Considering the promising cytotoxic effect of the compound, 1,4-NQ needs further evaluation as a potential candidate for the treatment of TNBC.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Breast cancer is the most-diagnosed cancer type among women.
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Key Findings & Data:Although chemotherapy is almost the only option for the treatment of triple-negative breast cancer (TNBC), currently used chemotherapeutics are not effective enough, considering the poor survival rate of patients.
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Conclusion & Impact:Considering the promising cytotoxic effect of the compound, 1,4-NQ needs further evaluation as a potential candidate for the treatment of TNBC.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Quinones · 4-naphthoquinones · cytotoxicity

Abstract

Breast cancer is the most-diagnosed cancer type among women. The triple-negative subtype is an especially aggressive type of breast cancer. Although chemotherapy is almost the only option for the treatment of triple-negative breast cancer (TNBC), currently used chemotherapeutics are not effective enough, considering the poor survival rate of patients. Therefore, novel compounds need to be developed to improve survival rates. It has been known that quinonic compounds, which are found in nature, have antibacterial, antifungal, and antitumorigenic properties. Naphthoquinones are members of the quinone family and are widely used in research due to their promising properties. In this study, we evaluated the cytotoxic activity of a novel naphthoquinone-derived compound (1,4-naphthoquinone (1,4-NQ)) against two different breast cancer cells: a hormone-responsive cell line (MCF-7) and a triple-negative cell line (MDA-MB-231). As a result, 1,4-NQ decreased cell viability in both tested cell lines in a dose-dependent manner. Increased apoptotic markers (presence of pyknotic nuclei, annexin-V positivity, caspase 3/7 activity, and decreased mitochondrial membrane potential) and DNA damage were especially observed in MDA-MB-231 cells after treatment with the compound. Considering the promising cytotoxic effect of the compound, 1,4-NQ needs further evaluation as a potential candidate for the treatment of TNBC.

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Cite This Article

KARAKAŞ, D., AKAR, R. O., GÖKMEN, Z., DENİZ, N. G., ULUKAYA, E. (2019). A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells. Turkish Journal of Biology, Cilt: 43 - Sayı: 4, 256–263. https://ajindex.com/articles/182282

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References (9)

  1. Arishya S, Singh K, Almasan A (2012). Histone H2AX phosphorylation: a marker for DNA damage. In: Arishya S, Singh K, Almasan A. DNA Repair Protocols. Totowa, NJ, USA: Humana Press, pp. 613-626.
  2. Bernd K (2003). DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling. Biochemical Pharmacology 66: 1547-1554.
  3. Bray F, Ferlay J, Soerjomataram I, Siegel R L, Torre LA et al. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68 (6): 394- 424. Brenton JD, Carey LA, Ahmed AA, Caldas C (2005). Molecular classification and molecular forecasting of breast cancer: ready for clinical application. Journal of Clinical Oncology 2005 (23): 7350-7360. da Silva AJ, Alcides JM, Netto CD, Pacienza-Lima W, Torres-Santos EC et al. (2009). Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1, 4-naphthoquinone derivatives. Journal of the Brazilian Chemical Society 20: 176-182. da Silva AJ, Buarque CD, Brito FV, Aurelian L, Macedo LF et al. (2002). Synthesis and preliminary pharmacological evaluation of new (±) 1, 4-naphthoquinones structurally related to lapachol. Bioorganic & Medicinal Chemistry 10: 2731-2738.
  4. Deniz NG, Ibis C, Gokmen Z, Stasevych M, Novikov V et al. (2015). Design, synthesis, biological evaluation, and antioxidant and cytotoxic activity of heteroatom-substituted 1,4-naphtho- and benzoquinones. Chemical and Pharmaceutical Bulletin 63: 1029-1039.
  5. Dolan ME, Frydman B, Thompson CB, Diamond AM, Garbiras BJ et al. (1998). Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents. Anti-Cancer Drugs 9: 437-448.
  6. Douglas GR, Kroemer G (2004). The pathophysiology of mitochondrial cell death. Science 305: 626-629.
  7. Driscoll JS (1974). Quinone structure-antitumor activity relationships. Cancer Chemother Rep 2 (4): 3-4.
  8. Foulkes WD, Smith IE, Reis-Filho JS (2010). Triple-negative breast cancer. New England Journal of Medicine 363: 1938-1948.
  9. Foye MO (1995). Cancer Chemotherapeutic Agents. Washington DC, USA: American Chemical Society. Guillermo M, Kroemer G (2013). Mechanisms of apoptotic phosphatidylserine exposure. Cell Research 23: 1247. Hillard EA, de Abreu FC, Ferreira DC, Jaouen G, Goulart MO et al. (2008). Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds. Chemica