Risk Factors for Invasive Bacterial Infection and Mortality in Febrile Neutropenic Children

Özet

Objective: Febrile neutropenia (FN) is a common and life-threatening complication that develops during therapy for childhood cancer. Serious bacterial illness is a significant cause of morbidity and mortality for neutropenic patients The primary objective of the study was to determine etiology and clinical course of fever in neutropenic children with cancer. The aim was to identify the risk of development of invasive bacterial infection (IBI) and factors associated with mortality in pediatric cancer FEN patients. Method: This study was conducted in University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital between January 2006 and and December 2013. Invasive bacterial infections and related mortality in children aged 0 to 18 years of age were documented. Results: A total of 325 neutropenic febrile episodes of 134 patients were evaluated. The most common preexisting risk factor for invasive bacterial infection was acute myeloid leukemia phenotyp. Other risk factors included, thrombocytopenia, bloodstream infection, C-reactive protein value >9 mg/dL and pneumoniae. In our case series overall infection- associated mortality was found as 4% similar as in the literature. Conclusion: Invasive bacterial infections is still be major cause of mortality and morbidity for pediatric leukemia.