Journals / Ege Tıp Dergisi / 2018 / Cilt: 57 - Sayı: 1

A novel predictor in acute kidney injury: Neutrophil to lymphocyte count

Akut böbrek hasarlanmasında yeni bir gösterge: Nötrofil-lenfosit oranı

Pages
8–13
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: NLR may be a novel screening tool on patiens' mortality for AKI patients during their hospital course.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Acute Kidney injury (AKI) represents a clinical condition reflecting systemic inflammation.
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Key Findings & Data:Results: It has been shown that, final NLR and timely changed NLR during hospital course are significant mortality predictors in AKI patients both in univariate and mutually adjusted multivariate logistic regression analysis.
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Conclusion & Impact:Conclusion: NLR may be a novel screening tool on patiens' mortality for AKI patients during their hospital course.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Acute Kidney injury (AKI) represents a clinical condition reflecting systemic inflammation. Neutrophil-tolymphocyte ratio (NLR) is novel prognostic marker in various inflammatory conditions. In this retrospective cohort we evaluated two hundred and thirteen AKI patients. Materials and Methods: The patients' baseline values on admission, final values at discharge and after discharging during follow-up period in outpatient clinic until six months to one year were recorded. NLR change during follow-up period after hospitalization was also examined. Results: It has been shown that, final NLR and timely changed NLR during hospital course are significant mortality predictors in AKI patients both in univariate and mutually adjusted multivariate logistic regression analysis. To predict mortality, we showed that, level of 9.90 point for final NLR has 73% sensitivity and 87% specifity as compared to value below in ROC analysis (HR: 7.31, CI 3.36-15.91; p<0.001). Conclusion: NLR may be a novel screening tool on patiens' mortality for AKI patients during their hospital course.

Özet

Amaç: Akut böbrek hasarlanması (ABH), sistemik inflamasyonu yansıtan bir klinik durumdur. Nötrofil-lenfosit oranı (NLO), değişik inflamatuar durumlarda bilinen yeni prognostik göstergedir. Bu retrospektif kohort çalışmasında iki yüz on üç akut böbrek hasarlanmalı hasta incelendi. Gereç ve Yöntem: Hastaların başvuru anı, çıkış anı ve taburculuk sonrası poliklinik takiplerinde var olan altı ay bir yıllık değerleri kaydedildi. Bu takip periyodunda hastaların NLO değişimleri incelendi. Bulgular: Tek değişkenli ve çoklu değişkenli regresyon analizlerinde, hem taburculuk anı NLO değeri hem de zamansal NLO değişimi, akut böbrek hasarlanmalı hastalarda bağımsız mortalite öngörücüsü olarak saptandı. Yapılan ROC analizinde, mortalite ön görücülüğünde, NLO üst sınır için 9.90 değeri, %87 özgüllük ve %73 duyarlılıkta saptandı (HR: 7.31, CI 3.36-15.91; p<0.001). Sonuç: Akut böbrek hasarlanmalı hastalarda, NLO, hastane yatış sürecinde mortalite için yeni bir takip parametresi olabilir.

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Cite This Article

BOZKURT, D., KILAVUZ, A., BERKTAŞ, M., AKÇİÇEK, S. F. (2018). A novel predictor in acute kidney injury: Neutrophil to lymphocyte count. Ege Tıp Dergisi, Cilt: 57 - Sayı: 1, 8–13. https://ajindex.com/articles/170416

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