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Journals / Turkish Journal of Kinesiology / 2026 / Volume: 12 Issue: 5

The physiological effects of exercise on the nervous system: A narrative review

Begüm Biçer Gez(Department of Physiotherapy and Rehabilitation, Graduate School of Health Sciences, Istanbul Medipol University, Istanbul, Türkiye.)0000-0002-0706-6817
Emine Atıcı(Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Istanbul Okan University, Istanbul, Türkiye.)0000-0002-6547-4798
Pages
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Publication Date
2026-10-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, current evidence supports exercise as a multidimensional stimulus for nervous system adaptation, with potential implications for maintaining neurological function and informing rehabilitation strategies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Exercise induces acute neurophysiological responses and long-term adaptations through interconnected cerebrovascular, neurochemical, neurotrophic, metabolic, and autonomic mechanisms.
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Key Findings & Data:This narrative review summarises the physiological effects of exercise on the nervous system, focusing on cerebral perfusion, neurotransmitter regulation, neuroplasticity, muscle–brain communication, lactate signalling, and autonomic function.
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Conclusion & Impact:Overall, current evidence supports exercise as a multidimensional stimulus for nervous system adaptation, with potential implications for maintaining neurological function and informing rehabilitation strategies.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Brain-derived neurotrophic factor · exercise · nervous system

Abstract

Exercise induces acute neurophysiological responses and long-term adaptations through interconnected cerebrovascular, neurochemical, neurotrophic, metabolic, and autonomic mechanisms. This narrative review summarises the physiological effects of exercise on the nervous system, focusing on cerebral perfusion, neurotransmitter regulation, neuroplasticity, muscle–brain communication, lactate signalling, and autonomic function. Exercise may support cognitive, emotional, and motor functions by modulating neurotransmitter systems and neurotrophic pathways, including those involving brain-derived neurotrophic factor (BDNF). Improvements in cerebral perfusion, endothelial function, and autonomic regulation may further contribute to neural and cerebrovascular health. Emerging evidence also suggests potential roles for skeletal muscle-derived mediators and lactate in peripheral–brain signalling; however, several proposed mechanisms, particularly neurogenesis and myokine-mediated effects, remain supported predominantly by preclinical studies. The magnitude and nature of these responses vary according to exercise characteristics and individual factors. Overall, current evidence supports exercise as a multidimensional stimulus for nervous system adaptation, with potential implications for maintaining neurological function and informing rehabilitation strategies.

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Cite This Article

Gez, B. B., Atıcı, E. (2026). The physiological effects of exercise on the nervous system: A narrative review. Turkish Journal of Kinesiology, Volume: 12 Issue: 5. https://doi.org/10.31459/turkjkin.2005033

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References (50)

  1. Alfini, A. J., Weiss, L. R., Nielson, K. A., Verber, M. D., & Smith, J. C. (2019). Resting cerebral blood flow after exercise training in mild cognitive impairment. J Alzheimers Dis, 67(2), 671-684. doi: 10.3233/JAD-180728
  2. Barzroodi Pour, M., Bayat, M., Golab, F., Eftekharzadeh, M., Katebi, M., Soleimani, M., & Karimzadeh, F. (2019). The effect of exercise on GABA signaling pathway in the model of chemically induced seizures. Life Sci, 232, 116667. doi: 10.1016/j.lfs.2019.116667
  3. Baumgartner, N. W., Belbis, M. D., Kargl, C., Holmes, M. J., Gavin, T. P., Hirai, D. M., & Kao, S. C. (2024). Acute effects of high-intensity resistance exercise on recognition of relational memory, lactate, and serum and plasma brain-derived neurotrophic factor. J Strength Cond Res, 38(11), 1867-1878. doi: 10.1519/JSC.0000000000004851
  4. Cefis, M., Chaney, R., Wirtz, J., Méloux, A., Quirié, A., Leger, C., Prigent-Tessier, A., & Garnier, P. (2023). Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction. Front Mol Neurosci, 16, 1275924. doi: 10.3389/fnmol.2023.1275924
  5. Cefis, M., Prigent-Tessier, A., Quirié, A., Pernet, N., Marie, C., & Garnier, P. (2019). The effect of exercise on memory and BDNF signaling is dependent on intensity. Brain Struct Funct, 224(6), 1975-1985. doi: 10.1007/s00429-019-01889-7
  6. Chaouloff, F. (1989). Physical exercise and brain monoamines: A review. Acta Physiol Scand, 137(1), 1-13. doi: 10.1111/j.1748-1716.1989.tb08715.x
  7. Chiang, J. K., Lin, Y. C., Hung, T. Y., Kao, H. H., & Kao, Y. H. (2024). The impact on autonomic nervous system activity during and following exercise in adults: A meta-regression study and trial sequential analysis. Medicina (Kaunas), 60(8), 1223. doi: 10.3390/medicina60081223
  8. Ding, Q., Ying, Z., & Gómez-Pinilla, F. (2011). Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing. Neuroscience, 192, 773-780. doi: 10.1016/j.neuroscience.2011.06.032
  9. Eaton, M., Granata, C., Barry, J., Safdar, A., Bishop, D., & Little, J. P. (2018). Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle. J Sport Health Sci, 7(2), 191-196. doi: 10.1016/j.jshs.2017.01.003
  10. El Hayek, L., Khalifeh, M., Zibara, V., Abi Assaad, R., Emmanuel, N., Karnib, N., El-Ghandour, R., Nasrallah, P., Bilen, M., Ibrahim, P., Younes, J., Abou Haidar, E., Barmo, N., Jabre, V., Stephan, J. S., & Sleiman, S. F. (2019). Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF). J Neurosci, 39(13), 2369-2382. doi: 10.1523/JNEUROSCI.1661-18.2019
  11. Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., Wojcicki, T. R., Mailey, E., Vieira, V. J., Martin, S. A., Pence, B. D., Woods, J. A., McAuley, E., & Kramer, A. F. (2011). Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A, 108(7), 3017-3022. doi: 10.1073/pnas.1015950108
  12. Farooqui, A. A. (2014). Effect of exercise on neurodegeneration in neurological disorders. In A. A. Farooqui (Ed.), Inflammation and oxidative stress in neurological disorders: Effect of lifestyle, genes, and age (pp. 143-173). Springer International Publishing. doi: 10.1007/978-3-319-04111-7_5
  13. Hittel, D. S., Axelson, M., Sarna, N., Shearer, J., Huffman, K. M., & Kraus, W. E. (2010). Myostatin decreases with aerobic exercise and associates with insulin resistance. Med Sci Sports Exerc, 42(11), 2023-2029. doi: 10.1249/MSS.0b013e3181e0b9a8
  14. Hwang, D., Kim, J., Kyun, S., Jang, I., Kim, T., Park, H. Y., & Lim, K. (2023). Exogenous lactate augments exercise-induced improvement in memory but not in hippocampal neurogenesis. Sci Rep, 13(1), 5838. doi: 10.1038/s41598-023-33017-1
  15. Ide, K., & Secher, N. H. (2000). Cerebral blood flow and metabolism during exercise. Prog Neurobiol, 61(4), 397-414. doi: 10.1016/S0301-0082(99)00057-X
  16. Jodeiri Farshbaf, M., & Alviña, K. (2021). Multiple roles in neuroprotection for the exercise-derived myokine irisin. Front Aging Neurosci, 13, 649929. doi: 10.3389/fnagi.2021.649929
  17. Kao, T., Shumsky, J. S., Knudsen, E. B., Murray, M., & Moxon, K. A. (2011). Functional role of exercise-induced cortical organization of sensorimotor cortex after spinal transection. J Neurophysiol, 106(5), 2662-2674. doi: 10.1152/jn.01017.2010
  18. Keller, C., Steensberg, A., Pilegaard, H., Osada, T., Saltin, B., Pedersen, B. K., & Neufer, P. D. (2001). Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: Influence of muscle glycogen content. FASEB J, 15(14), 2748-2750. doi: 10.1096/fj.01-0507fje
  19. Klein, T., Bailey, T. G., Abeln, V., Schneider, S., & Askew, C. D. (2019). Cerebral blood flow during interval and continuous exercise in young and old men. Med Sci Sports Exerc, 51(7), 1523-1531. doi: 10.1249/MSS.0000000000001924
  20. Kleinloog, J. P. D., Nijssen, K. M. R., Mensink, R. P., & Joris, P. J. (2023). Effects of physical exercise training on cerebral blood flow measurements: A systematic review of human intervention studies. Int J Sport Nutr Exerc Metab, 33(1), 47-59. doi: 10.1123/ijsnem.2022-0085
  21. Klempin, F., Beis, D., Mosienko, V., Kempermann, G., Bader, M., & Alenina, N. (2013). Serotonin is required for exercise-induced adult hippocampal neurogenesis. J Neurosci, 33(19), 8270-8275. doi: 10.1523/JNEUROSCI.5855-12.2013
  22. Kostka, M., Morys, J., Małecki, A., & Nowacka-Chmielewska, M. (2024). Muscle-brain crosstalk mediated by exercise-induced myokines: Insights from experimental studies. Front Physiol, 15, 1488375. doi: 10.3389/fphys.2024.1488375
  23. Lavín-Pérez, A. M., Collado-Mateo, D., Mayo, X., Liguori, G., Humphreys, L., & Jiménez, A. (2021). Can exercise reduce the autonomic dysfunction of patients with cancer and its survivors? A systematic review and meta-analysis. Front Psychol, 12, 712823. doi: 10.3389/fpsyg.2021.712823
  24. Li, F., Liu, B. B., Cai, M., Li, J. J., & Lou, S. J. (2018). Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise. Brain Res Bull, 140, 52-59. doi: 10.1016/j.brainresbull.2018.04.003
  25. Li, X., Inoue, T., Hayashi, M., & Maejima, H. (2019). Exercise enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic alterations in senescence-accelerated mice prone 8. Neurosci Lett, 706, 176-181. doi: 10.1016/j.neulet.2019.05.031
  26. Lin, T. W., & Kuo, Y. M. (2013). Exercise benefits brain function: The monoamine connection. Brain Sci, 3(1), 39-53. doi: 10.3390/brainsci3010039
  27. Liu, P. Z., & Nusslock, R. (2018). Exercise-mediated neurogenesis in the hippocampus via BDNF. Front Neurosci, 12, 52. doi: 10.3389/fnins.2018.00052
  28. McDonnell, M. N., Buckley, J. D., Opie, G. M., Ridding, M. C., & Semmler, J. G. (2013). A single bout of aerobic exercise promotes motor cortical neuroplasticity. J Appl Physiol, 114(9), 1174-1182. doi: 10.1152/japplphysiol.01378.2012
  29. Moon, H. Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S. T., Greig, N. H., Mattison, J. A., Duzel, E., & van Praag, H. (2016). Running-induced systemic cathepsin B secretion is associated with memory function. Cell Metab, 24(2), 332-340. doi: 10.1016/j.cmet.2016.05.025
  30. Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020). Lactate and BDNF: Key mediators of exercise-induced neuroplasticity? J Clin Med, 9(4), 1136. doi: 10.3390/jcm9041136
  31. Murrell, C. J., Cotter, J. D., Thomas, K. N., Lucas, S. J. E., Williams, M. J. A., & Ainslie, P. N. (2013). Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training. Age (Dordr), 35(3), 905-920. doi: 10.1007/s11357-012-9414-x
  32. Nedelescu, H., Chowdhury, T. G., Wable, G. S., Arbuthnott, G., & Aoki, C. (2017). Cerebellar subdivisions differ in exercise-induced plasticity of noradrenergic axons and in their association with resilience to activity-based anorexia. Brain Struct Funct, 222(1), 317-339. doi: 10.1007/s00429-016-1220-2
  33. Pahlavani, H. A. (2023). Exercise therapy to prevent and treat Alzheimer's disease. Front Aging Neurosci, 15, 1243869. doi: 10.3389/fnagi.2023.1243869
  34. Pedersen, B. K. (2019). Physical activity and muscle-brain crosstalk. Nat Rev Endocrinol, 15(7), 383-392. doi: 10.1038/s41574-019-0174-x
  35. Perez, E. C., Bravo, D. R., Rodgers, S. P., Khan, A. R., & Leasure, J. L. (2019). Shaping the adult brain with exercise during development: Emerging evidence and knowledge gaps. Int J Dev Neurosci, 78, 147-155. doi: 10.1016/j.ijdevneu.2019.06.006
  36. Petzinger, G. M., Holschneider, D. P., Fisher, B. E., McEwen, S., Kintz, N., Halliday, M., Toy, W., Walsh, J. W., Beeler, J., & Jakowec, M. W. (2015). The effects of exercise on dopamine neurotransmission in Parkinson’s disease: Targeting neuroplasticity to modulate basal ganglia circuitry. Brain Plast, 1(1), 29-39. doi: 10.3233/BPL-150021
  37. Querido, J. S., & Sheel, A. W. (2007). Regulation of cerebral blood flow during exercise. Sports Med, 37(9), 765-782. doi: 10.2165/00007256-200737090-00002
  38. Rosenwinkel, E. T., Bloomfield, D. M., Arwady, M. A., & Goldsmith, R. L. (2001). Exercise and autonomic function in health and cardiovascular disease. Cardiol Clin, 19(3), 369-387. doi: 10.1016/S0733-8651(05)70223-X
  39. Ruderman, N. B., Keller, C., Richard, A. M., Saha, A. K., Luo, Z., Xiang, X., Giralt, M., Ritov, V. B., Menshikova, E. V., Kelley, D. E., Hidalgo, J., Pedersen, B. K., & Kelly, M. (2006). Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes, 55(Suppl 2), S48-S54. doi: 10.2337/db06-S007
  40. Sá Filho, A. S., Barsanulfo, S. R., Faria, S. S., Inacio, P. A., Ayatizadeh, F., & Machado, S. (2024). Exerkines: A crosstalk between lactate production, exercise and mental health. CNS Neurol Disord Drug Targets, 23(9), 1057-1060. doi: 10.2174/0118715273250928231009054658
  41. Schiffer, T., Schulte, S., Sperlich, B., Achtzehn, S., Fricke, H., & Strüder, H. K. (2011). Lactate infusion at rest increases BDNF blood concentration in humans. Neurosci Lett, 488(3), 234-237. doi: 10.1016/j.neulet.2010.11.035
  42. Shabkhiz, F., Khalafi, M., Rosenkranz, S., Karimi, P., & Moghadami, K. (2021). Resistance training attenuates circulating FGF-21 and myostatin and improves insulin resistance in elderly men with and without type 2 diabetes mellitus: A randomised controlled clinical trial. Eur J Sport Sci, 21(4), 636-645. doi: 10.1080/17461391.2020.1762755
  43. Smith, E. C., Pizzey, F. K., Askew, C. D., Mielke, G. I., Ainslie, P. N., Coombes, J. S., & Bailey, T. G. (2021). Effects of cardiorespiratory fitness and exercise training on cerebrovascular blood flow and reactivity: A systematic review with meta-analyses. Am J Physiol Heart Circ Physiol, 321(1), H59-H76. doi: 10.1152/ajpheart.00880.2020
  44. Soshi, T., Andersson, M., Kawagoe, T., Nishiguchi, S., Yamada, M., Otsuka, Y., Nakai, R., Abe, N., Aslah, A., Igasaki, T., & Sekiyama, K. (2021). Prefrontal plasticity after a 3-month exercise intervention in older adults relates to enhanced cognitive performance. Cereb Cortex, 31(10), 4501-4517. doi: 10.1093/cercor/bhab102
  45. Steventon, J. J., Chandler, H. L., Foster, C., Dingsdale, H., Germuska, M., Massey, T., Parker, G., Wise, R. G., & Murphy, K. (2021). Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training. Sci Rep, 11(1), 22061. doi: 10.1038/s41598-021-01630-7
  46. Tanaka, H. (2009). Cerebral blood flow: Sleeping beauty awakened by exercise. Exerc Sport Sci Rev, 37(3), 111. doi: 10.1097/JES.0b013e3181aa5aee
  47. Wang, J., Chen, X., Zhang, N., & Ma, Q. (2013). Effects of exercise on stress-induced changes of norepinephrine and serotonin in rat hippocampus. Chin J Physiol, 56(5), 245-252. doi: 10.4077/CJP.2013.BAB097
  48. Wilhelm, J. C., Xu, M., Cucoranu, D., Chmielewski, S. E., Holmes, T. M., Lau, K. S., Bassell, G. J., & English, A. W. (2012). Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration. J Neurosci, 32(14), 5002-5009. doi: 10.1523/JNEUROSCI.1411-11.2012
  49. Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013). Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab, 18(5), 649-659. doi: 10.1016/j.cmet.2013.09.008
  50. Young, M. F., Valaris, S., & Wrann, C. D. (2019). A role for FNDC5/irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases. Prog Cardiovasc Dis, 62(2), 172-178. doi: 10.1016/j.pcad.2019.02.007