Cancer Associated with Dysplasia in Patients with Cholecystectomy

Objective & Hypothesis:Objective: Changes in steps of carcinogenesis such as metaplasia and dysplasia in cases with chronic cholecystitis that develop due to cholelithiasis and progress with chronic inflammation may be significant in terms of other intra-abdominal organ neoplasms.

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Key Findings & Data:Method: Sixty-eight patients who had dysplasia after cholecystectomy operation between 01.01.2010 and 01.07.2012 in General Surgery Clinic of Eskişehir Osmangazi University Faculty of Medicine Hospital were evaluated retrospectively in terms of accompanying gastrointestinal malignancy.

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Conclusion & Impact:Keywords: Cholecystectomy, metaplasia-dysplasia,

🔬Design:Research Article

📍Scope:2010 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: Changes in steps of carcinogenesis such as metaplasia and dysplasia in cases with chronic cholecystitis that develop due to cholelithiasis and progress with chronic inflammation may be significant in terms of other intra-abdominal organ neoplasms. As in our study, cases with metaplasia and dysplasia should be also screened in other intraabdominal systems. Method: Sixty-eight patients who had dysplasia after cholecystectomy operation between 01.01.2010 and 01.07.2012 in General Surgery Clinic of Eskişehir Osmangazi University Faculty of Medicine Hospital were evaluated retrospectively in terms of accompanying gastrointestinal malignancy. Results: In 2 of 68 patients whose histopathological examination results after cholecystectomy were compatible with dysplasia/metaplasia, accompanying malignancy; In 2 of them, new gastrointestinal system malignancies that emerged as a result of annual follow-up were determined. Conclusion: Patients with metaplasia/dysplasia in the pathology results after cholecystectomy should be followed up closely for gastrointestinal system malignancies. Keywords: Cholecystectomy, metaplasia-dysplasia,

Özet

Amaç: Kolelityazise bağlı gelişen ve kronik inflamasyonla seyreden kronik kolesistitli olgulardaki metaplazi ve displazi gibi karsinogenez basamağında yer alan değişimler, batın içi diğer organ neoplazmlar açısından anlamlı olabilir. Çalışmamızda da olduğu gibi metaplazi ve displazi görülen olgularda kesinlikle batın içi diğer sistemler de taranmalıdır. Yöntem: Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Hastanesi Genel Cerrahi Kliniğinde 01.01.2010 ile 01.07.2012 tarihleri arasında kolesistektomi yapılan nihayi histopatolojik analiz sonucu displazi ile karşılaşılan 68 hasta eşlik eden ve gastrointestinal malignite açısından retrospektif olarak değerlendirildi. Bulgular: Kolesistektomi ameliyatı sonrası histopatolojik inceleme sonuçları displazi/metaplazi ile uyumlu olan 68 hastanın 2’sinde eşlik eden malignite; 2’sinde ise yıllık takipler sonucu ortaya çıkan yeni gastrointestinal sistem maligniteleri belirlenmiştir. Sonuç: Kolesistektomi sonrası patoloji sonuçlarında metaplazi/displazi olan olgular gastrointestinal sistem maligniteleri açısından yakın takibe alınmalıdırlar.

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Cite This Article

BADAK, B., YILMAZ, A. Ş., SALİS, M., ÖZTOP, M. B. (2020). Cancer Associated with Dysplasia in Patients with Cholecystectomy. İzmir Tepecik Eğitim Hastanesi Dergisi, Cilt: 30 - Sayı: 2, 109–112. https://ajindex.com/articles/165126

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References (7)

Research NIoHOoMAo. Gallstones and laparoscopic cholecystectomy: National Institutes of Health, Office of Medical Applications of Research; 1992
Bahadır B, Gün BD, Çolak S, Kertiş G, Cömert M, Özdamar ŞO. Safra kesesinde metaplazi, displazi ve karsinom dizgesi. Akademik Gastroenteroloji Dergisi. 2007;6(1):25-9
Kroh M, Chalikonda S, Chand B, Walsh RM. Laparoscopic completion cholecystectomy and common bile duct exploration for retained gallbladder after single-incision cholecystectomy. JSLS: Journal of the Society of Laparoendoscopic Surgeons. 2013;17(1):143. [CrossRef] 4. Ünal AE, Erpek H, Özgün H, Çevikel MH, Özbaş MS, Gürel M. İlk 416 laparoskopik kolesistektomi olgularımızın analizi. 2001
Amiraslanov A, Yusif-zade K, Musayev J. Laparoskopik kolesistektomi uygulanan olgularda safra kesesinin histopatolojik profili. Marmara Medical Journal. 2015;28(1):32-7. [CrossRef] 6. Memon W. Histopathological spectrum of gall bladder specimens after cholecystectomy. 2011
Adsay N. Gallbladder, extrahepatic biliary tree, and ampulla. Sternberg’s Diagnostic Surgical Pathology. 2004:1775-6
Jagannath SB, Singh VK, Cruz-Correa M, Canto MIF, Kalloo AN. A long-term cohort study of outcome after cholecystectomy for chronic acalculous cholecystitis. The American Journal of Surgery. 2003;185(2):91-5. [CrossRef] 9. Domeyer PJ, Sergentanis TN, Zagouri F, Tzilalis B, Mouzakioti E, Parasi A, et al. Chronic cholecystitis in elderly patients. Correlation of the severity of inflammation with the number and size of the stones. In Vivo. 2008;22(2):269-72
Lohsiriwat V, Vongjirad A, Lohsiriwat D. Value of routine histopathologic examination of three common surgical specimens: appendix, gallbladder, and hemorrhoid. World Journal of Surgery. 2009;33(10):2189-93. [CrossRef] 11. Seretis C, Lagoudianakis E, Gemenetzis G, Seretis F, Pappas A, Gourgiotis S. Metaplastic changes in chronic cholecystitis: implications for early diagnosis and surgical intervention to prevent the gallbladder metaplasia-dysplasia-carcinoma sequence. Journal of clinical medicine research. 2014;6(1):26. [CrossRef] 12. Yamamoto M, Nakajo S, Tahara E. Dysplasia of the gallbladder: its histogenesis and correlation to gallbladder adenocarcinoma. Pathology-Research and Practice. 1989;185(4):454- 60. [CrossRef] 13. Dowling GP, Kelly JK. The histogenesis of adenocarcinoma of the gallbladder. Cancer. 1986;58(8):1702-8. [CrossRef]