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Journals / Glokom Katarakt / 2018 / Cilt: 13 - Sayı: 1

Comparison of Ketorolac Tromethamine 0.4% and Nepafenac 0.1% for the Prevention of Cystoid Macular Oedema After Phacoemulsifi cation: Prospective Placebo-Controlled Study

Fakoemülsifi kasyon Cerrahisi Sonrası Kistoid Makula Ödemi Oluşumunun Engellenmesi için %0.4 Ketorolak trometamin ve %0.1 Nepafenak Kullanımın Karşılaştırılması: Prospektif Plasebo-Kontrollü Çalışma

MUSTAFA DOĞAN
Serkan ÖZCAN
İlkin VALİYEV
Onur POLAT
Pages
27–31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Used prophylactically after uneventful cataract surgery, non-steroidal anti-infl ammatory drugs were found effective in preventing macular oedema.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To compare the anti-infl ammatory effi cacy of ketorolac-tromethamine 0.4% and nepafenac 0.1% eye drops for prophylaxis of cystoid macular oedema (CME) following uncomplicated cataract extraction.
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Key Findings & Data:Group 1 patients received ketorolac-tromethamine 0.4% (Acular LS, Allergan); group 2 received nepafenac 0.1% (Nevanac, Alcon) and group 3 received topical arti- fi cial tear substitute ( placebo)(Start on operation day, continue 4 weeks q.i.d.) The incidence and severity of CME were evaluated by central macular thickness (CMT) and total macular volume (TMV) on optical coherence tomography (OCT) post-operative 1 week and 4 weeks.
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Conclusion & Impact:Conclusion: Used prophylactically after uneventful cataract surgery, non-steroidal anti-infl ammatory drugs were found effective in preventing macular oedema.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To compare the anti-infl ammatory effi cacy of ketorolac-tromethamine 0.4% and nepafenac 0.1% eye drops for prophylaxis of cystoid macular oedema (CME) following uncomplicated cataract extraction. Materials and Methods: Patients were assigned randomly to three groups in this prospective, placebo-controlled, randomised study. Group 1 patients received ketorolac-tromethamine 0.4% (Acular LS, Allergan); group 2 received nepafenac 0.1% (Nevanac, Alcon) and group 3 received topical arti- fi cial tear substitute ( placebo)(Start on operation day, continue 4 weeks q.i.d.) The incidence and severity of CME were evaluated by central macular thickness (CMT) and total macular volume (TMV) on optical coherence tomography (OCT) post-operative 1 week and 4 weeks. Results: Ninety-six eyes of 96 patients were included in this study. The differences between groups in CMT and total macular volume on time pre-o- perative, post-operative 1 week and post-operative 4 weeks were not statistically signifi cant. The differences in CMT and TMV between 4 week and baseline were not statistically signifi cant in NSAI group. In control group, CMT and TMV were signifi cant higher at 4 weeks (p=0.04, p=0.024, res- pectively). Conclusion: Used prophylactically after uneventful cataract surgery, non-steroidal anti-infl ammatory drugs were found effective in preventing macular oedema.

Özet

Amaç: Katarakt cerrahisi sonrası kistoid makula ödemi (KMÖ) profi laksisinde kullanılan anti-infl amatuar %0.4 ketorolak trometamin ve %0.1 nepa- fenak göz damlalarının etkinliğini karşılaştırmak. Gereç ve Yöntem: Prospektif, randomize, plasebo kontrollü çalışmamızda, hastalar 3 grupta incelendi. Birinci gruba % 0.4 ketorolak trometamin (Acular LS, Allergan), ikinci gruba % 0.1 nepafenak (Nevanac, Alcon) ve üçüncü gruba suni gözyaşı damlası (plasebo), cerrahi günü başlayarak 4 hafta boyunca günde 4 defa bir damla şeklinde verildi. Postoperatif 1. hafta ve postoperatif 4. haftada optik koherens tomografi ile santral makula kalınlığı (SMK) ve total maküler volüm (TMV) ölçülerek KMÖ sıklığı ve şiddeti değerlendirildi. Bulgular: Çalışmaya 96 hastanın 96 gözü dahil edildi. Gruplar arasında ameliyat öncesi, ameliyat sonrası 1. hafta ve ameliyat sonrası 4.hafta ortalama SMK ve TMV değerleri arasında istatistiksel olarak anlamlı farklılık saptanmadı. NSAI kullanan hastalarda 4. haftada ölçülen SMK ve TMV ile ame- liyat öncesi ölçülen SMK ve TMV arasında istatistiksel olarak anlamlı fark saptanmadı. Kontrol grubunda, 4. haftada SMK ve TMV anlamlı yüksek saptandı (sırasıyla p=0.04, p=0.024). Sonuç: Komplikasyonsuz katarakt cerrahi sonrası, KMÖ profi laksisinde kullanılan topikal non-steroid anti-infl amatuar damlaların etkinliği gözlendi.

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Cite This Article

DOĞAN, M., ÖZCAN, S., VALİYEV, İ., POLAT, O. (2018). Comparison of Ketorolac Tromethamine 0.4% and Nepafenac 0.1% for the Prevention of Cystoid Macular Oedema After Phacoemulsifi cation: Prospective Placebo-Controlled Study. Glokom Katarakt, Cilt: 13 - Sayı: 1, 27–31. https://ajindex.com/articles/164990

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