Journals / Fırat Tıp Dergisi / 2018 / Cilt: 23 - Sayı: 4

Facial Edema Developed After Use of Olanzapine: A Case Rep

Olanzapin Kullanımına Bağlı Gelişen Fasiyal Ödem: Olgu Sunumu

Pages
203–205
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We think that it may be a contribution to the relevant literature to report this side-effect, whose pathophysiology needs to be clearly explained with more research.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Olanzapine is an atypical antipsychotic medicine which has proven its’ success in the treatment of some psychiatric disorders, primarily affective bipolar disorder, schizophrenia, and similar psychotic disorders.
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Key Findings & Data:Such frequent anticholinergic side-effects as weight-gain, sedation, dry mouth and constipation may be observed in patients using Olanzapine; besides, it is reported in a study that Olanzapine may lead to peripheral edema in 3% of the cases.
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Conclusion & Impact:We think that it may be a contribution to the relevant literature to report this side-effect, whose pathophysiology needs to be clearly explained with more research.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Olanzapine is an atypical antipsychotic medicine which has proven its’ success in the treatment of some psychiatric disorders, primarily affective bipolar disorder, schizophrenia, and similar psychotic disorders. Such frequent anticholinergic side-effects as weight-gain, sedation, dry mouth and constipation may be observed in patients using Olanzapine; besides, it is reported in a study that Olanzapine may lead to peripheral edema in 3% of the cases. However, there are few studies reporting of facial edema. The case is a 21 years old female patient, treatment was started with a psychotic attack on the 13th day of olanzapine treatment, during the systemic examination of the patient who had difficulty in opening his eyes, no other finding other than facial edema was observed. When olanzapine treatment was stopped, the facial edema started to decrease, and disappeared nearly one week later. We think that it may be a contribution to the relevant literature to report this side-effect, whose pathophysiology needs to be clearly explained with more research.

Özet

Olanzapin bipolar affektif bozukluk, şizofreni ve benzeri psikotik bozukluklar başta olmak üzere psikiyatrik hastalıkların tedavisinde başarısı kanıtlanmış atipik antipsikotik ilaçtır. Olanzapin kullanan hastalarda sıklıkla kilo artışı, sedasyon, ağız kuruluğu ve kabızlık gibi antikolinerjik yan tesirleri görülmekle birlikte yapılan bir çalışmada Olanzapinin %3 gibi bir oranda periferik ödeme yol açtığı bildirilmiştir. Ancak fasyial ödem gelişen olgu bildirimleri azdır. Olgu 21 yaşında kadın hasta, Psikotik atak tanısıyla tedavi başlandı. Olanzapin tedavisinin 13. günü göz kapaklarını açmakta güçlük çeken hastada yapılan sistemik muayenede fasiyal ödem dışında bulguya rastlanmadı. Olanzapin tedavisi sonlandırıldıktan sonra fasiyal ödem azalmaya başladı ve yaklaşık bir hafta sonra kayboldu. Patofizyolojisinin tam açıklanabilmesi için yeni araştırmalara ihtiyaç duyulan bu yan etkiyi tedavi uyumunu bozabileceği ve dikkat edilmediğinde gözden kaçabileceği için bildirimini yaparak literatüre katkı yapabileceğimizi düşündük.

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Cite This Article

GÜROK, M. G., YILDIZ, S., KORUCU, T., KELEŞ, D. D., GÜROK, N. G., ATMACA, M. (2018). Facial Edema Developed After Use of Olanzapine: A Case Rep. Fırat Tıp Dergisi, Cilt: 23 - Sayı: 4, 203–205. https://ajindex.com/articles/164910

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