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Journals / BEYOGLU EYE JOURNAL / 2020 / Cilt: 5 - Sayı: 2

Importance of Müller Cells

Sabiha GÜNGÖR KOBAT
Burak TURGUT
Pages
59–63
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review is a summary of the functions of MCs and a discussion of the importance of these glial cells.

📌 3 Key Takeaways

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Objective & Hypothesis:Müller cells (MCs) are the most common glial cell found in the human retina.
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Key Findings & Data:Additionally, there has been consideration that MC dysfunction might contribute to the pathogenesis of some retinal diseases, such as proliferative vitreoretinopathy, diabetic retinopathy, macular edema, retinal vein occlusion, macular telangiectasia type 2, age-related macular degeneration, retinal degeneration, hepatic and methanol-induced retinopathy, and glaucoma.
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Conclusion & Impact:This review is a summary of the functions of MCs and a discussion of the importance of these glial cells.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Müller cells (MCs) are the most common glial cell found in the human retina. MCs have an important role in architectural and metabolic functions in the retina. Additionally, there has been consideration that MC dysfunction might contribute to the pathogenesis of some retinal diseases, such as proliferative vitreoretinopathy, diabetic retinopathy, macular edema, retinal vein occlusion, macular telangiectasia type 2, age-related macular degeneration, retinal degeneration, hepatic and methanol-induced retinopathy, and glaucoma. This review is a summary of the functions of MCs and a discussion of the importance of these glial cells.

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Cite This Article

KOBAT, S. G., TURGUT, B. (2020). Importance of Müller Cells. BEYOGLU EYE JOURNAL, Cilt: 5 - Sayı: 2, 59–63. https://ajindex.com/articles/164584

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References (15)

  1. Müller H. Zur Histologie der Netzhaut. [Article in Germany] Z Wissenschaft Zool 1851;3:234–7
  2. Bhattacharjee J, Sanyal S. Developmental origin and early differentiation of retinal Müller cells in mice. J Anat 1975;120:367– 72
  3. Sild M, Ruthazer ES. Radial glia: progenitor, pathway, and partner. Neuroscientist 2011;17:288–302
  4. Bernardos RL, Barthel LK, Meyers JR, Raymond PA. Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. J Neurosci 2007;27:7028–40
  5. Goldman D. Müller glial cell reprogramming and retina regeneration. Nat Rev Neurosci 2014;15:431–42
  6. Hamon A, Roger JE, Yang XJ, Perron M. Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems. Dev Dyn 2016;245:727–38
  7. Bhatia B, Jayaram H, Singhal S, Jones MF, Limb GA. Differences between the neurogenic and proliferative abilities of Müller glia with stem cell characteristics and the ciliary epithelium from the adult human eye. Exp Eye Res 2011;93:852–61
  8. Cislo-Pakuluk A, Marycz K. A Promising Tool in Retina Regeneration: Current Perspectives and Challenges When Using Mesenchymal Progenitor Stem Cells in Veterinary and Human Ophthalmological Applications. Stem Cell Rev Rep 2017;13:598–602
  9. Phillips JB, Blanco-Sanchez B, Lentz JJ, Tallafuss A, Khanobdee K, Sampath S, et al. Harmonin (Ush1c) is required in zebrafish Müller glial cells for photoreceptor synaptic development and function. Dis Model Mech 2011;4:786–800
  10. Fausett BV, Goldman D. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J Neurosci 2006;26:6303–13
  11. Raymond PA, Barthel LK, Bernardos RL, Perkowski JJ. Molecular characterization of retinal stem cells and their niches in adult zebrafish. BMC Dev Biol 2006;6:36
  12. Franze K, Grosche J, Skatchkov SN, Schinkinger S, Foja C, Schild D, et al. Muller cells are living optical fibers in the vertebrate retina. Proc Natl Acad Sci U S A 2007;104:8287–92
  13. Giannelli SG, Demontis GC, Pertile G, Rama P, Broccoli V. Adult human Müller glia cells are a highly efficient source of rod photoreceptors. Stem Cells 2011;29:344–56
  14. Reichenbach A, Faude F, Enzmann V, Bringmann A, Pannicke T, Francke M, et al. The Müller (glial) cell in normal and diseased retina: a case for single-cell electrophysiology. Ophthalmic Res 1997;29:326–40
  15. Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, et al. TRPV4 and AQP4 C