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Journals / Ağrı Tıp Fakültesi Dergisi / 2025 / Cilt: 3 Sayı: 3

Clinicopathological and prognostic outcomes of endometriosis-associated ovarian cancer

Endometriozisle ilişkili over kanserinin klinikopatolojik ve prognostik sonuçları

Esra Keles(İstanbul Kartal Dr Lütfi Kırdar Şehir Hastanesi)0000-0001-8099-8883
Sahra Sultan Kara(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL DR. LÜTFİ KIRDAR ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-5122-829X
Sadun Sucu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-3758-0136
Pages
102–106
Publication Date
2025-10-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, survival outcomes did not significantly differ between EAOC and non-EAOC groups.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: The aim of this study is to investigate the clinicopathological characteristics and prognostic value of endometriosis in patients with ovarian cancer.
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Key Findings & Data:Materials and Methods: A retrospective analysis was performed on 273 patients with ovarian carcinoma between January 2013 and December 2023.
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Conclusion & Impact:However, survival outcomes did not significantly differ between EAOC and non-EAOC groups.
🔬Design:Araştırma Makalesi
📍Scope:2013 Verileri
⚙️Variables:Endometriozis · Over neoplazileri · Endometriozisle ilişkili over kanseri

Abstract

Aim: The aim of this study is to investigate the clinicopathological characteristics and prognostic value of endometriosis in patients with ovarian cancer. Materials and Methods: A retrospective analysis was performed on 273 patients with ovarian carcinoma between January 2013 and December 2023. Patients were stratified into endometriosis-associated ovarian carcinoma (EAOC) and non-endometriosis-associated ovarian carcinoma (non-EAOC). Clinicopathological variables, including age, menopausal status, tumor size and volume, FIGO stage, histological subtype, serum tumor markers, and survival outcomes, were evaluated. Results: EAOC patients were significantly younger than non-EAOC patients (respectively 51 ± 11.4 years, 59 ± 11.2 years; p = 0.002). EAOC cases were more frequently diagnosed at FIGO stage I than non-EAOC cases (p = 0.001), whereas FIGO stage (III) disease was more prevalent in the non-EAOC group (p = 0.007). No significant differences were observed in CA-125 levels between groups. CA 19-9 levels were elevated in the EAOC group (p = 0.012). Recurrence rates and survival outcomes did not differ significantly between the groups. Conclusion: EAOC cases were diagnosed at a younger age and presented at an earlier FIGO stage and had elevated CA 19-9 levels. However, survival outcomes did not significantly differ between EAOC and non-EAOC groups.

Özet

Amaç: Bu çalışmanın amacı, over kanseri olan hastalarda endometriozisin klinikopatolojik özelliklerini ve prognostik değerini araştırmaktır. Gereçler ve Yöntemler: Ocak 2013 ile Aralık 2023 tarihleri arasında over karsinomu tanısı alan 273 hasta retrospektif olarak analiz edildi. Hastalar, endometriozisle ilişkili over karsinomu (EAOC) ve endometriozisle ilişkili olmayan over karsinomu (non-EAOC) olmak üzere iki gruba ayrıldı. Yaş, menopoz durumu, tümör boyutu ve hacmi, FIGO evresi, histolojik alt tip, serum tümör belirteçleri ve sağkalım sonuçları gibi klinikopatolojik değişkenler değerlendirildi. Bulgular: EAOC hastaları, non-EAOC hastalarına göre anlamlı düzeyde daha gençti (sırasıyla 51 ± 11,4 yıl, 59 ± 11,2 yıl; p = 0,002). EAOC grubunda FIGO evre I’de tanı alma oranı daha yüksekti (p = 0,001), buna karşılık non-EAOC grubunda evre III hastalık daha yaygındı (p = 0,007). Gruplar arasında CA-125 düzeylerinde anlamlı fark saptanmazken, CA 19-9 düzeyleri EAOC grubunda daha yüksekti (p = 0,012). Nüks oranları ve sağkalım sonuçları gruplar arasında anlamlı fark göstermedi. Sonuç: EAOC hastaları daha genç yaşta ve daha erken FIGO evresinde tanı almakta ve CA 19-9 düzeyleri daha yüksek bulunmaktaydı. Ancak, EAOC ve non-EAOC grupları arasında sağkalım sonuçları açısından anlamlı fark gözlenmedi.

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Cite This Article

Keles, E., Kara, S. S., Sucu, S. (2025). Clinicopathological and prognostic outcomes of endometriosis-associated ovarian cancer. Ağrı Tıp Fakültesi Dergisi, Cilt: 3 Sayı: 3, 102–106. https://doi.org/10.61845/agrimedical.1674787

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