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Journals / Sakarya University Journal of Science / 2026 / Volume: 24 Issue: 1

Synthesis of novel 8-formyl-7-hydroxy-4-methylcoumarin derivatives

Hülya Çelik Onar(MÜHENDİSLİK FAKÜLTESİ)0000-0003-2573-5751
Didem Erdoğan(İSTANBUL ÜNİVERSİTESİ - CERRAHPAŞA, LİSANSÜSTÜ EĞİTİM ENSTİTÜSÜ)
Pages
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Publication Date
2020-02-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Their structures were identified by IR, 1 H NMR, 13 C NMR , MS analysis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study was initiated by 7-hydroxy-4-methylcoumarin 1 synthesis according to the Peckmann reaction with resorcinol and ethylacetoacetate.
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Key Findings & Data:This compound was converted into 8-formyl-7-hydroxy -4-methylcoumarin 2 compound by the Duff reaction.
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Conclusion & Impact:Their structures were identified by IR, 1 H NMR, 13 C NMR , MS analysis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Schiff base · coumarin · Pechmann reaction

Abstract

This study was initiated by 7-hydroxy-4-methylcoumarin 1 synthesis according to the Peckmann reaction with resorcinol and ethylacetoacetate. This compound was converted into 8-formyl-7-hydroxy -4-methylcoumarin 2 compound by the Duff reaction. This aldehyde obtained was reacted with 6-amino-1,4-benzodioxane and 2-amino benzamide, which have their specific biological activities, to synthesize the original two novel compounds. While 3 ( 7-Hydroxy-4-methyl-8-[(2,3-dihidro-1,4-benzodioxin-6-yl)iminomethyl]-2H-1-benzopiran-2-on ) is obtained as a coumarin schiff base, ring closure was observed at 4 ( 2-(2’-Hydoxy-5-methyl coumarin-1-yl)-2,3-dihidro quinazoline-4(1H)-on ). Our compounds are thought to exhibit biological activity. Their structures were identified by IR, 1 H NMR, 13 C NMR , MS analysis.

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Cite This Article

Onar, H. Ç., Erdoğan, D. (2020). Synthesis of novel 8-formyl-7-hydroxy-4-methylcoumarin derivatives. Sakarya University Journal of Science, Volume: 24 Issue: 1. https://doi.org/10.16984/saufenbilder.503046

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