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Journals / Journal of the Turkish Chemical Society Section A: Chemistry / 2019 / Volume: 6 Issue: 3

ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES

Hülya Çelik Onar(İstanbul Üniversitesi-Cerrahpaşa)0000-0003-2573-5751
Fatma Ceren Anlaş(İstanbul Üniversitesi- Cerrahpaşa)0000-0002-7997-016X
Hasniye Yaşa(İstanbul Üniversitesi - Cerrahpaşa)0000-0003-3171-9096
Fulya Üstün Alkan(İstanbul Üniversitesi - Cerrahpaşa)0000-0003-1782-9467
Belma Hasdemir(İstanbul Üniversitesi - Cerrahpaşa)0000-0002-1071-1127
Tülay Bakırel(İstanbul Üniversitesi Cerrahpaşa)0000-0001-5805-2178
Pages
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Publication Date
2019-10-20
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Among these compounds, 8-semicarbazone eicosanoic acid ( 3 ) and 10-keto eicosanoic acid anilide ( 9 ) displayed effective cytotoxic potential against CMT-U27 and IC 50 concentrations were recorded at 1.952 µ M and 54.00 µ M , respectively.

📌 3 Key Takeaways

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Objective & Hypothesis:T his study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM ) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin.
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Key Findings & Data:T his study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM ) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin.
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Conclusion & Impact:Among these compounds, 8-semicarbazone eicosanoic acid ( 3 ) and 10-keto eicosanoic acid anilide ( 9 ) displayed effective cytotoxic potential against CMT-U27 and IC 50 concentrations were recorded at 1.952 µ M and 54.00 µ M , respectively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anilide · Semicarbazone · Fatty Acid

Abstract

T his study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM ) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin. Among these compounds, 8-semicarbazone eicosanoic acid ( 3 ) and 10-keto eicosanoic acid anilide ( 9 ) displayed effective cytotoxic potential against CMT-U27 and IC 50 concentrations were recorded at 1.952 µ M and 54.00 µ M , respectively.

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Cite This Article

Onar, H. Ç., Anlaş, F. C., Yaşa, H., Alkan, F. Ü., Hasdemir, B., Bakırel, T. (2019). ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES. Journal of the Turkish Chemical Society Section A: Chemistry, Volume: 6 Issue: 3. https://doi.org/10.18596/jotcsa.583845

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