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Journals / Sakarya University Journal of Science / 2020 / Volume: 24 Issue: 6

Investigation of Neuregulin-1 Gen rs6994992 Polymorphism in Gifted Students in Turkish Population

Fikriye Polat(Kocaeli Üniversitesi)0000-0002-5414-2501
Tuğba Bayram(KOCAELİ ÜNİVERSİTESİ, FEN BİLİMLERİ ENSTİTÜSÜ)0000-0003-2850-6938
Burcu Yüksel(KOCAELİ ÜNİVERSİTESİ, KOCAELİ SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU)0000-0001-8691-6447
Pages
—
Publication Date
2020-12-01
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: According to the results of our study, there was no relationship between NRG1 rs6994992 polymorphism and gifted students in the Turkish population.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The aim of this study is to investigate whether neuregulin-1 gene (NRG1) rs6994992 polymorphism has any role in gifted students in Turkish population.
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Key Findings & Data:Methods: During the 2017-2018 academic year, 97 gifted students (experiment group) and 99 students with normal development (control group) attending 5th grade of different public schools participated in the research.
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Conclusion & Impact:Conclusion: According to the results of our study, there was no relationship between NRG1 rs6994992 polymorphism and gifted students in the Turkish population.
🔬Design:Modeling & Simulation
📍Scope:2017-2018 Verileri
⚙️Variables:NRG1 · rs6994992 · SNP

Abstract

Aim: The aim of this study is to investigate whether neuregulin-1 gene (NRG1) rs6994992 polymorphism has any role in gifted students in Turkish population. Methods: During the 2017-2018 academic year, 97 gifted students (experiment group) and 99 students with normal development (control group) attending 5th grade of different public schools participated in the research. Genomic DNA was extracted from the oral epithelial cells. Genotyping of the molecular variant was performed by Polymerase Chain Reaction- Agarose gel electrophoresis-DNA sequencing techniques. Results: Genotype difference in gifted students was estimated as odds ratio and 95% confidence interval using binary logistic regression models. While the frequencies of CC (wild type), CT (heterozygous), TT (polymorphic type) genotypes were 33.0, 53.6 and 13.4%for the experimental group, respectively, they were observed as 33.0, 60.0 and 7.0% in the control group. In the Turkish population, no association could be detected for both genotype and allele distribution for NRG1 rs6994992 C/T polymorphism between gifted and control group (OR: 0.538, CI: 0.190-1.525, p = 0.244). Conclusion: According to the results of our study, there was no relationship between NRG1 rs6994992 polymorphism and gifted students in the Turkish population.

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Cite This Article

Polat, F., Bayram, T., Yüksel, B. (2020). Investigation of Neuregulin-1 Gen rs6994992 Polymorphism in Gifted Students in Turkish Population. Sakarya University Journal of Science, Volume: 24 Issue: 6. https://doi.org/10.16984/saufenbilder.780155

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