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Journals / Veterinary Journal of Mehmet Akif Ersoy University / 2023 / Volume: 8 Issue: 3

The effect of oral administration of robenacoxib on hematological and biochemical parameters in different goat breeds

Zeynep Özdemir Kütahya(ÇUKUROVA ÜNİVERSİTESİ)0000-0002-3245-7975
Petek Piner Benli(ÇUKUROVA ÜNİVERSİTESİ)0000-0003-2324-9047
Pages
206–211
Publication Date
2023-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, it was concluded that robenacoxib did not have a negative effect on kidney and liver functions and blood components in Alpine and Saanen goats in administered dose and treatment period in this study.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Robenacoxib is a coxib-class, highly selective cyclooxygenase-2 inhibitor that is used for the control of pain and inflammation.
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Key Findings & Data:This study aimed to determine the effect on hematological and biochemical parameters 24 hours after oral administration of robenacoxib to healthy Alpine and Saanen goats.
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Conclusion & Impact:As a result, it was concluded that robenacoxib did not have a negative effect on kidney and liver functions and blood components in Alpine and Saanen goats in administered dose and treatment period in this study.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:robenacoxib · biochemical · hematological

Abstract

Robenacoxib is a coxib-class, highly selective cyclooxygenase-2 inhibitor that is used for the control of pain and inflammation. This study aimed to determine the effect on hematological and biochemical parameters 24 hours after oral administration of robenacoxib to healthy Alpine and Saanen goats. The study was conducted on healthy females, 1-2 years old Alpine (n=5) and Saanen (n=5) goats. A single dose of robenacoxib was administered orally to goats at a dose of 4 mg/kg body weight. Blood samples were taken before (0 hour) and 24 hours after the administration of robenacoxib for the evaluation of hematological and biochemical changes. The results of this study showed that statistical differences in hematological and biochemical parameters were within the normal limits in Alpine and Saanen goats except lactate dehydrogenase in Saanen goats. Furthermore, no differences were observed in hematological parameters between goat breeds; it can be claimed that the Alpine breed is more susceptible to negative pharmacological side effects than the Saanen breed according to changes in biochemical parameters. As a result, it was concluded that robenacoxib did not have a negative effect on kidney and liver functions and blood components in Alpine and Saanen goats in administered dose and treatment period in this study. Further studies need to investigate the effects of robenacoxib in high doses, long-term use, and in disease conditions, especially on the kidney.

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Cite This Article

Kütahya, Z. Ö., Benli, P. P. (2023). The effect of oral administration of robenacoxib on hematological and biochemical parameters in different goat breeds. Veterinary Journal of Mehmet Akif Ersoy University, Volume: 8 Issue: 3, 206–211. https://doi.org/10.24880/maeuvfd.1347911

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References (35)

  1. Amin, H. M., El-Feki, M. A., Abdalla, A. A., Youssef, M. A. (2017). Hematological and biochemical effects of meloxicam in male albino rats. Current Science International, 6(1), 23-33.
  2. Anderson, D. E., & Muir, W. W. (2005). Pain management in ruminants. The Veterinary Clinics of North America. Food Animal Practice, 21(1), 19–31. https://doi.org/10.1016/j.cvfa.2004.12.008
  3. Azab, M. E., Abdel-Maksoud, H. A. (1999). Changes in some hematological and biochemical parameters during prepartum and postpartum periods in female Baladi goats. Small Ruminant Research, 34(1), 77-85. https://doi.org/10.1016/S0921-4488(99)00049-8
  4. Clark, T. P. (2006). The clinical pharmacology of cyclooxygenase‐2–selective and dual inhibitors. Veterinary Clinics of North America: Small Animal, 36(5), 1061–1085. https://doi.org/10.1016/j.cvsm.2006.07.001
  5. Durna Çorum, D., & Yıldız, R. (2020). Koyunlarda karprofenin çoklu doz uygulamalarının hematolojik ve biyokimyasal parametreler üzerine etkisi. Eurasian Journal of Veterinary Sciences, 36(3), 166-171. https://doi.org/10.15312/EurasianJVetSci.2020.274
  6. Ersoy, O. (2012). Karaciğer enzim yüksekliğinin değerlendirilmesi. Ankara Medical Journal, 12(3), 129-135. European Medicines Agency. (2008). Onsior: European Public Assessment Report, Scientific discussion. https://www.ema.europa.eu/en/documents/scientific-discussion/onsior-epar-scientific-discussion_en.pdf
  7. Fadel, C., Łebkowska-Wieruszewska, B., Zizzadoro, C., Lisowski, A., Poapolathep, A., Giorgi, M. (2023). Pharmacokinetics of robenacoxib following single intravenous, subcutaneous and oral administrations in Baladi goats (Capra hircus). Journal of Veterinary Pharmacology and Therapeutics, 00, 1-8. https://doi.org/10.1111/jvp.13396
  8. Flower, R. J. (2003). The development of COX2 inhibitors. Nature Reviews. Drug Discovery, 2(3), 179–191. https://doi.org/10.1038/nrd1034
  9. Gall, C. (1996). Goat breeds of the world. Technical Centre for Agricultural and Rural Cooperation. Wageningen, Netherlands, pg: 5-8, 10-11.
  10. Gertz, B. J., Krupa, D., Bolognese, J. A., Sperling, R. S., Reicin, A. (2002). A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents, 18(2), 82-91. https://doi.org/10.1185/030079902125000354
  11. Gowda, S., Desai, P. B., Hull, V. V., Math, A. A. K., Vernekar, S. N., Kulkarni, S. S. (2009). A review on laboratory liver function tests. The Pan African Medical Journal, 3, 17.
  12. Gray, P.R., & McDonell, W.N. (1986). Anaesthesia in goats and sheep. Part I. Local analgesia. Compendium on Continuing Education for the Practising Veterinarian, 8, S33-S39.
  13. Gunaydin, C., & Sirri Bilge, S. (2018). Effects of nonsteroidal anti-inflammatory drugs at the molecular level. The Eurasian Journal of Medicine, 50(2), 116-121. https://doi.org/10.5152/eurasianjmed.2018.0010
  14. Harris, R. C. (2006). COX- and the kidney. Journal of Cardiovascular Pharmacology, 47(1), S37-S42. https://doi.org/10.1097/00005344-200605001-00007
  15. Heit, M. C., Stallons, L. J., Seewald, W., Thompson, C. M., Toutain, C. E., King, S. B., Helbig, R. (2020). Safety evaluation of the interchangeable use of robenacoxib in commercially‐available tablets and solution for injection in cats. BMC Veterinary Research, 16(1), 355. https://doi.org/10.1186/s12917-020-02553-7
  16. Kim, S. Y., & Moon, A. (2012). Drug-induced nephrotoxicity and its biomarkers. Biomolecules & Therapeutics, 20(3), 268-272. https://doi.org/10.4062/biomolther.2012.20.3.268
  17. Leese, P. T., Hubbard, R. C., Karim, A., Isakson, P. C., Yu, S. S., Geis, G. S. (2000). Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: A randomized, controlled trial. Journal of Clinical Pharmacology, 40, 124-132. https://doi.org/10.1177/00912700022008766
  18. Morita, I., Schindler, M., Reiger, M. K., Otto, J. C., Hori, T., De Witt, D.L., Smith, W. L. (1995). Different intracellular locations for prostaglandin endoperoxide H synthase-1 and 2. The Journal of Biological Chemistry, 270(18), 10902- 10908. https://doi.org/10.1074/jbc.270.18.10902
  19. Noborisaka, Y., Ishizaki M., Yamazaki M., Honda R., Yamada, Y. (2013). Elevated serum gamma-glutamyltransferase (GGT) activity and the development of chronic kidney disease (CKD) in cigarette smokers. Nephro-urology Monthly, 5(5), 967-973. https://doi.org/10.5812/numonthly.13652
  20. Owumi, S. E., Dim, U. J. (2019). Biochemical alterations in diclofenac-treated rats: Effect of selenium on oxidative stress, inflammation, and hematological changes. Toxicology Research and Application, 3, 1-10. https://doi.org/10.1177/2397847319874359
  21. Özdemir, Z., & Traş, B. (2018). Organlarda ilaç yan etkilerinin değerlendirilmesi. Türkiye Klinikleri Veteriner Bilimleri Farmakoloji ve Toksikoloji (Veteriner Farmakovijilans), 45-52.
  22. Pozzobon, R., Brass, K. E,. Rubin, M. I. B., De La Corte, F. D., Paniz, C., Soccal, R. M., Azevedo, M. S., Milanello, E. R., Silva, G. B. (2009). Meloxicam and ketoprofen did not alter coagulation and haematological parameters of healthy ponies. Proceedings of the 11th International Congress of World Equine Veterinary Association, Guarujá, SP, Brazil.
  23. Shirali, A., Perazella, M. A. (2015). Drug-induced nephropathies. In: N.N. Turner, N. Lameire, D. J. Goldsmith, C. G. Winearls, J. Himmelfarb, G. Remuzzi (Ed.). Oxford Textbook of Clinical Nephrology (pp. 2893). Oxford University Press.
  24. Smith, J. S., Schleining, J., Plummer, P. (2021). Pain management in small ruminants and camelids: Analgesic agents. Veterinary Clinics of North America: Food Animal Practice, 37, 1–16.
  25. Steagall, P. V. M., Mantovani, F. B., Ferreira, T. H., Salcedo, S., Moutinho, F. Q., Luna, S. P. L. (2007). Evaluation of the adverse effects of oral firocoxib in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics, 30(3), 218-223. https://doi.org/10.1111/j.1365-2885.2007.00842.x
  26. Tabrizi A. S., Kamrani A., Kazerani, H. (2006). Effects of celecoxib on gastric mucosa, hemogram and bleeding time in dog. Proceedings of the 31st World Small Animal Veterinary Association World Congress Proceedings. Parague, Czech Rebublic.
  27. Tang, W., & Lu, A. Y. H. (2010). Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective. Drug Metabolism Reviews, 42(2), 225-249. https://doi.org/10.3109/03602530903401658
  28. Thrall, M. A. (2004). Veterinary hematology and clinical chemistry. Williams and Wilkins, Philadelphia, 277-289. Tibbo, M., Jibril, Y., Woldemeskel, M., Dawo, F., Aragaw, K., Rege, J. E. O. (2004). Factors affecting hematological profiles in three Ethiopian indigenous goat breeds. Journal of Applied Research in Veterinary Medicine, 2(4), 297-309. https://doi.org/10.1007/s00580-004-0525-3
  29. Toutain, C. E., Heit, M. C., King, S. B., Helbig, R. (2017). Safety evaluation of the interchangeable use of robenacoxib (Onsior™) tablets and solution for injection in dogs. BMC Veterinary Research, 13(1), 359. https://doi.org/10.1186/s12917-017-1269-z
  30. Traş, B., Yazar, E., Elmas, M. (2021). Veteriner ilaç rehberi: Ağrı kesici, ateş düşürücü ve yangı giderici ilaçlar. Nobel Tıp Kitabevleri, Atlas Kitabevi, sf: 334.
  31. Villegas, I., Alarcón de la Lastra, C., Martín, M. J., Motilva, V., La Casa García, C. (2002). Gastric damage induced by subchronic administration of preferential cyclooxygenase-1 and cyclooxygenase-2 inhibitors in rats. Pharmacology, 66(2), 68–75. https://doi.org/10.1159/000065628
  32. Warner, T. D., Giuliano, F., Vojnovic, I., Bukasa, A., Mitchell, J. A., Vane, J. R. (1999). Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proceedings of the National Academy of Sciences of the United States of America, USA, 96(13), 7563-7568. https://doi.org/10.1073/pnas.96.13.7563
  33. Whelton, A., Schulman, G., Wallemark, C., Drower, E. J., Isakson, P. C., Verburg, K. M., Geis, G. S. (2000). Effects of celecoxib and naproxen on renal function in the elderly. Archives of Internal Medicine, 160(10), 1465-1470. https://doi.org/10.1001/archinte.160.10.1465
  34. Wright, J. M. (2002). The double-edged sword of COX-2 selective NSAIDs. CMAJ: Canadian Medical Association Journal, 167(10), 1131–1137.
  35. Heit, M. C., Stallons, L. J., Seewald, W., Thompson, C. M., Toutain, C. E., King, S. B., Helbig, R. (2020). Safety evaluation of the interchangeable use of robenacoxib in commercially‐available tablets and solution for injection in cats. BMC Veterinary Research, 16(1), 355. https://doi.org/10.1186/s12917-020-02553-7