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Journals / Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni / 2025 / Cilt: 16 Sayı: 3

CIRCADIAN RHYTHM AND CHRONOPHARMACOLOGY IN VETERINARY MEDICINE

VETERİNER HEKİMLİKTE SİRKADİYEN RİTİM VE KRONOFARMAKOLOJİ

Selen Mamuk(ÇUKUROVA ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0009-0008-1105-9127
Zeynep Özdemir Kütahya(ÇUKUROVA ÜNİVERSİTESİ, CEYHAN VETERİNER FAKÜLTESİ, KLİNİK ÖNCESİ BİLİMLERİ BÖLÜMÜ)0000-0002-3245-7975
Pages
132–138
Publication Date
2025-12-22
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This could facilitate broader adoption of chronopharmacology in veterinary practice and enhance therapeutic outcomes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Chronopharmacology is the scientific discipline that studies the interaction between drug timing and biological rhythms, particularly circadian rhythms, and how this interaction affects drug efficacy and safety.
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Key Findings & Data:In veterinary medicine, this field is crucial because the timing of drug administration, when aligned with an animal's biological rhythms, can significantly enhance treatment outcomes.
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Conclusion & Impact:This could facilitate broader adoption of chronopharmacology in veterinary practice and enhance therapeutic outcomes.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Kronofarmakoloji · kronokinetik · sirkadiyen ritim

Abstract

Chronopharmacology is the scientific discipline that studies the interaction between drug timing and biological rhythms, particularly circadian rhythms, and how this interaction affects drug efficacy and safety. In veterinary medicine, this field is crucial because the timing of drug administration, when aligned with an animal's biological rhythms, can significantly enhance treatment outcomes. Circadian rhythms are biological processes regulated by a 24-hour cycle and influenced by factors such as light, melatonin, sleep, and nutrition. These rhythms can impact pharmacokinetic (drug absorption, distribution, metabolism and excretion) and pharmacodynamic (biological effects of drugs) processes. The timing of drug administration plays a critical role in not only enhancing therapeutic efficacy but also reducing side effects. For example, some drugs may be more effective when administered in the morning, while others may show greater efficacy at night. However, research in veterinary chronopharmacology remains limited. This review aims to highlight the importance of chronopharmacology and circadian rhythms in veterinary medicine in treatments applied and to address gaps in knowledge on this subject. By considering the biological rhythms of animals, veterinarians can optimize drug timing, leading to improved treatment success and better management of side effects. This could facilitate broader adoption of chronopharmacology in veterinary practice and enhance therapeutic outcomes.

Özet

Kronofarmakoloji, ilaçların biyolojik ritimlerle, özellikle sirkadiyen ritimlerle etkileşimini ve bu etkileşimin ilaçların etkinliği ve güvenliği üzerindeki etkilerini inceleyen bir bilim dalıdır. Veteriner hekimlikte bu alanın önemi, ilaçların verilme zamanının hayvanların biyolojik ritimleriyle uyumlu olduğunda tedavi başarısını artırabilmesidir. Sirkadiyen ritimler, canlıların 24 saatlik döngülerle düzenlenen biyolojik süreçleridir ve ışık, melatonin, uyku, beslenme gibi faktörlerden etkilenir. Bu ritimler, farmakokinetik (ilaç emilimi, dağılımı, metabolizması ve atılımı) ve farmakodinamik (ilaçların biyolojik etkileri) süreçleri üzerinde değişikliklere yol açabilir. İlaçların zamanlaması, tedavi etkinliğini artırmanın yanı sıra, yan etkilerin de azaltılmasında önemli bir rol oynar. Örneğin, bazı ilaçlar sabah saatlerinde daha etkili olabilirken, diğerleri gece saatlerinde daha verimli olabilir. Ancak veteriner hekimlikte bu alanda yapılan araştırmalar sınırlıdır. Bu derleme, veteriner hekimlik alanında uygulanan tedavilerde kronofarmakoloji ve sirkadiyen ritimlerin önemini vurgulamayı ve bu konudaki bilgi eksikliklerini gidermeyi amaçlamaktadır. Veteriner hekimler, hayvanların biyolojik ritimlerini göz önünde bulundurarak ilaç zamanlamasını düzenlediğinde, tedavideki başarı oranı da artabilecektir.

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Cite This Article

Mamuk, S., Kütahya, Z. Ö. (2025). CIRCADIAN RHYTHM AND CHRONOPHARMACOLOGY IN VETERINARY MEDICINE. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni, Cilt: 16 Sayı: 3, 132–138. https://doi.org/10.38137/vftd.1753671

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