AI Summary & Key Takeaways
AI InsightAlthoughour results showed that about half of our patients took a toxic iron dose; the severity of toxicity was mild in a majority of them.
📌 3 Key Takeaways
Abstract
Aim: In this study we aimed to analyze the demographic properties, clinical variables, treatment, complications of patients presenting to emergency department (ED) with iron toxicity. Material and Method: This is a retrospective study. It enrolled patients presenting to the ED of a tertiary training hospital for treatment of iron toxicity. Patients with missing medical data, pregnancy, and toxicity secondary to non-iron medications were excluded. The patients were divided into 2 groups by the amount of iron. A p value of less than 0.05 was considered statistically significant. Results: 61 patients were enrolled in the study. 73.8% patients were women, and the study population had a median age of 32 (24-37) years. The mean amount of elementary iron intake was 1000 (710-1950) mg, with a fourth-hour iron level being 246 mg/dl (median, IQR 25-76: 119-327). There was a significant positive correlation between the amount of iron intake and blood iron level (p=0.02). Laboratory test monitoring showed a decrease in hemoglobin, platelet, and creatinine levels and an increase in INR level (for all parameters, p 0.05). Conclusion: Iron toxicitymay be encountered in clinical practice at ED. Althoughour results showed that about half of our patients took a toxic iron dose; the severity of toxicity was mild in a majority of them. We found a decrease in hemoglobin, platelet, and creatinine levels at laboratory but we dont believe that this finding is clinically meaningful. We detected an increase in INR level, which we believe may indicate tissue affection at cellular level without a clinical affection.
Özet
Amaç: Bu çalışmada, acil kliniğine demir intoksikasyonu nedeniyle başvuran hastaların; demografik, klinik değişkenleri, tedavileri ve komplikasyonlarını değerlendirmeyi amaçladık. Materyal ve Metot: Bu çalışma retrospektif bir çalışmadır. Üçüncü basamak eğitim hastanesinin acil kliniğinde demir intoksikasyonu tanısı alan ve takip edilen hastalar çalışmaya dahil edildi. Verileri eksik olanlar, gebeler, demir dışı ilaçlarla zehirlenen hastalar çalışma dışı bırakıldı. Hastalar demir miktarına göre 2 gruba ayrıldı. P 0.05). Sonuç: Demir zehirlenmesi acil serviste klinik pratikte görülebilen zehirlenmelerdir. Çalışma bulgularımıza göre hastalarımızın yaklaşık yarısı toksik doz demir almış olsa da büyük bir kısmında zehirlenme şiddetinin hafif olduğu görülmüştür. Hastaların labaratuvar takiplerinde hemoglobin, platelet ve creatinin değerlerinde azalma saptadık ancak klinikte anlamlı olduğunu düşünmüyoruz. Çalışmamızda INR değerlerinde artma saptadık, bu durumun klinik etkilenme olmadan hücresel düzeyde doku etkilenmesini gösterebileceğini düşünüyoruz.