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Journals / Kafkas Journal of Medical Sciences / 2026 / Cilt: 15 Sayı: EK-1

Management Strategies for Synchronous Primary Lung Tumors: A Retrospective Two-Centre Study

Demet Yaldız(Department of Thoracic Surgery, Manisa Celal Bayar University Faculty of Medicine, Manisa)
Güntuğ Batıhan(Department of Thoracic Surgery, Kafkas University Faculty of Medicine, Kars, Türkiye)
Arkın Acar(Department of Thoracic Surgery, Manisa Celal Bayar University Faculty of Medicine, Manisa)
Pages
51–55
Publication Date
2025-10-20
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Comprehensive clinical evaluation, detailed histopathologic assessment, and individualized management strategies are essential to optimize outcomes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Synchronous primary lung tumors are uncommon and diverse clinical entities.
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Key Findings & Data:Distinguishing them from intrapulmonary metastases is essential for accurate staging, prognosis evaluation, and selecting the right treatment.
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Conclusion & Impact:Comprehensive clinical evaluation, detailed histopathologic assessment, and individualized management strategies are essential to optimize outcomes.
🔬Design:Review & Systematic Survey
📍Scope:2023 Verileri
⚙️Variables:Synchronous lung tumors · multiple primary lung cancers · surgical management

Abstract

Aim: Synchronous primary lung tumors are uncommon and diverse clinical entities. Distinguishing them from intrapulmonary metastases is essential for accurate staging, prognosis evaluation, and selecting the right treatment. This study seeks to describe the clinical, radiological, and histopathological features of synchronous primary lung tumors and to aid in the diagnostic and treatment decision-making process. Material and Methods: Between January 2023 and January 2025, patients diagnosed with synchronous primary lung tumors and evaluated at two tertiary centers were retrospectively analyzed. Clinical, radiological, and histopathological data were reviewed, including smoking history, occupational or environmental exposures, and TNM staging. Treatment strategies and follow-up outcomes were recorded. Results: Out of 250 patients undergoing diagnostic or therapeutic interventions for lung cancer during the study period, four patients (1.6%) met the criteria for synchronous primary lung tumors. Detailed case-based analyses highlighted the heterogeneity in histologic subtypes, anatomical locations, and treatment approaches. Conclusion: Synchronous primary lung tumors are rare but clinically significant. Comprehensive clinical evaluation, detailed histopathologic assessment, and individualized management strategies are essential to optimize outcomes.

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Cite This Article

Yaldız, D., Batıhan, G., Acar, A. (2025). Management Strategies for Synchronous Primary Lung Tumors: A Retrospective Two-Centre Study. Kafkas Journal of Medical Sciences, Cilt: 15 Sayı: EK-1, 51–55. https://ajindex.com/articles/1631523

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References (14)

  1. Niu N, Zhou L, Zhao J, Ma X, Yang F, Qi W. Sublobar resection versus lobectomy in the treatment of synchronous multiple primary lung cancer. World Journal of Surgical Oncology. 2023;21(1):135.
  2. Gazdar AF, Minna J D. Multifocal lung cancers--clonality vs f ield cancerization and does it matter?. Journal of the National Cancer Institute. 2009;101(8):541–543.
  3. Rostad H, Strand TE, Naalsund A, Norstein J. Resected synchronous primary malignant lung tumors: a population-based study. The Annals of Thoracic Surgery. 2008;85(1):204–209.
  4. Watanabe T, Tanahashi M, Suzuki E, Yoshii N, Tsuchida H, Yobita S, et al. Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?. Thoracic Cancer. 2021;12(22):2996–3004.
  5. Raju SC, Peters GW, Decker RH, Park HS. Clinical Outcomes and Safety Profile in the Treatment of Synchronous Nonmetastatic Lung Tumors With Stereotactic Body Radiation Therapy. Practical Radiation Oncology. 2022;12(2):e110–e116.
  6. Martini N, Melamed MR. Multiple primary lung cancers. J T horac Cardiovasc Surg. 1975;70:606–612.
  7. Stiles BM. Say goodbye to Martini and Melamed: genomic classification of multiple synchronous lung cancers. Journal of T horacic Disease. 2017;9(1):E87-E88.
  8. Ishikawa Y, Nakayama H, Ito H, Yokose T, Tsuboi M, Nishii T, et al. Surgical treatment for synchronous primary lung adenocarcinomas. The Annals of Thoracic Surgery. 2014;98(6):1983–1988.
  9. Shen KR, Meyers BF, Larner JM, Jones DR. Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007;132:290S-305S.
  10. Chen C, Huang X, Peng M, Liu W, Yu F, Wang X. Multiple primary lung cancer: a rising challenge. J Thorac Dis. 2019;11(Suppl 4):523–36.
  11. Brunelli A, Kim AW, Berger KI, Addrizzo‐Harris DJ. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence‐based clinical practice guidelines. Chest. 2013;143:166–90.
  12. Wu X, Huang W, Geng T, Wei Y. Next-Generation Sequencing of Synchronous Multiple Primary Lung Cancers in a Patient with Squamous Cell Carcinoma and Small Cell Lung Cancer. OncoTargets and therapy. 2020;13:11621–11626.
  13. Yang DS, Huang K, Su M, Wang TT, Liu SS, Xu Y, et al. Nextgeneration sequencing revealed synchronous double primary lung squamous carcinoma: a case report. The Journal of International Medical Research. 2021;49(5):3000605211018575.
  14. Shen KR, Meyers BF, Larner JM, Jones DR. Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007;132:290S-305S.