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Journals / Kafkas Journal of Medical Sciences / 2026 / Cilt: 16 Sayı: 1

Diagnostic Value and Prognostic Significance of Laboratory Parameters in Adult COVID-19 Patients Admitted to the Intensive Care Unit by Age Group

Murat Genç(Department Of Emergency Medicine, Ankara Training And Research Hospital, Ankara, Turkey)
Bensu Bulut(Emergency Medicine Department, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey)
Medine Akkan Öz(Emergency Medicine Department, GülhaneTraining and Research Hospital, Ankara, Turkey)
Ayşenur Gür(Etimesgut State Hospital, Department Of Emergency Medicine, Ankara, Turkey)
Hüseyin Mutlu(Aksaray University, Faculty of Medicine, Emergency Medicine Department, Aksaray, Turkey)
Ramiz Yazıcı(Emergency Medicine Department, University of Health Sciences, Kanuni Sultan Suleyman Training and Research Hospital, İstanbul, Turkey)
Dilek Atik(Emergency Medicine Department, Karamanoğlu Mehmetbey University, Karaman, Turkey)
Betül Çiğdem Yortanlı(Internal Medicine Department, University of Health Sciences, Konya City Hospital, Konya, Turke)
Eyüp Sarı(Pediatrics Department, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey)
Mehmet Yortanlı(Department of Emergency Medicine, Konya Numune Hospital, Konya, Turkey)
Pages
11–16
Publication Date
2026-03-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings suggest that age-specific laboratory reference values may improve risk assessment and clinical management of COVID-19 patients in intensive care settings

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: COVID-19 presents with heterogeneous clinical manifestations and laboratory findings across different age groups.
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Key Findings & Data:This study aimed to investigate the diagnostic and prognostic value of laboratory parameters in adult patients with COVID-19 admitted to the Intensive Care Unit, with particular emphasis on age groups.
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Conclusion & Impact:These findings suggest that age-specific laboratory reference values may improve risk assessment and clinical management of COVID-19 patients in intensive care settings
🔬Design:Araştırma Makalesi
📍Scope:2020 Verileri
⚙️Variables:COVID-19 · biomarkers · intensive care

Abstract

Aim: COVID-19 presents with heterogeneous clinical manifestations and laboratory findings across different age groups. This study aimed to investigate the diagnostic and prognostic value of laboratory parameters in adult patients with COVID-19 admitted to the Intensive Care Unit, with particular emphasis on age groups. Materials and methods: This retrospective study included 283 PCRconfirmed COVID-19 patients admitted to intensive care at Ankara Yenimahalle Training and Research Hospital between March 15 and June 15, 2020. Patients were divided into four age groups: middle-aged (45–59 years, n=49), elderly (60–74 years, n=101), advanced elderly (75–89 years, n=122), and very elderly (≥90 years, n=11). Demographic data, clinical outcomes, and laboratory parameters were collected and analysed. The predictive value of laboratory parameters for mortality was assessed using ROC curve analysis. Results: Significant differences were observed in clinical outcomes across age groups, with the highest discharge rate in the 75–89 age group and lower rates in both the 45–59 and ≥90 age groups (p <0.05). Laboratory parameters, including WBC, neutrophils, platelets, monocytes, MPV, RDW, ferritin, CRP, procalcitonin, and D-dimer, showed significant differences across age groups (p<0.05). ROC curve analysis identified CRP (cut-off: 120.8 mg/L, sensitivity: 63.5%, specificity: 61%, AUC: 0.679) and D-dimer (cut-off: 1795 ng/mL, sensitivity: 91.8%, specificity: 72%, AUC: 0.627) as significant predictors of mortality in COVID-19 patients over 45 years. Conclusion: This study demonstrates that CRP and D-dimer are reliable biomarkers for predicting mortality in elderly COVID-19 patients who require intensive care. The unexpected result that the advanced elderly group (75–89 years) had more favourable outcomes than both the younger (45–59) and the very elderly (≥90) groups was notable. These findings suggest that age-specific laboratory reference values may improve risk assessment and clinical management of COVID-19 patients in intensive care settings

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Cite This Article

Genç, M., Bulut, B., Öz, M. A., Gür, A., Mutlu, H., Yazıcı, R., Atik, D., Yortanlı, B. Ç., Sarı, E., Yortanlı, M. (2026). Diagnostic Value and Prognostic Significance of Laboratory Parameters in Adult COVID-19 Patients Admitted to the Intensive Care Unit by Age Group. Kafkas Journal of Medical Sciences, Cilt: 16 Sayı: 1, 11–16. https://ajindex.com/articles/1631480

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