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Journals / Avrupa Yaşam Bilimleri Dergisi / 2026 / Volume: 1 Issue: 1

Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors

Derya Osmaniye(ANADOLU ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK KİMYA ANABİLİM DALI)0000-0002-0499-436X
Begüm Nurpelin Saglik(ANADOLU ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK KİMYA ANABİLİM DALI)0000-0002-0151-6266
Serkan Levent(ANADOLU ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK KİMYA ANABİLİM DALI)0000-0003-3692-163X
Yusuf Özkay(ANADOLU ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK KİMYA ANABİLİM DALI)0000-0001-8815-153X
Zafer Asım Kaplancıklı(ANADOLU ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASOTİK KİMYA ANABİLİM DALI)0000-0003-2252-0923
Pages
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Publication Date
2022-04-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the obtained results, compound 2d with IC 50 =0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC 50 =0.074±0.003 µM.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases.
📊
Key Findings & Data:Within the scope of this study, 7 new piperazine-dithiocarbamate derivative compounds were synthesized.
💡
Conclusion & Impact:According to the obtained results, compound 2d with IC 50 =0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC 50 =0.074±0.003 µM.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Dithiocarbamate · HRMS · Monoamine oxidase

Abstract

Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases. While MAO-A inhibitors are used in depression; MAO-B enzyme has an important place in Parkinson's disease. Within the scope of this study, 7 new piperazine-dithiocarbamate derivative compounds were synthesized. Structure determinations of the compounds were performed using 1H-NMR, 13 C-NMR and HRMS spectroscopic methods. The MAO inhibitory activities of the compounds were determined by in vitro fluorometric methods. According to the obtained results, compound 2d with IC 50 =0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC 50 =0.074±0.003 µM.

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Cite This Article

Osmaniye, D., Saglik, B. N., Levent, S., Özkay, Y., Kaplancıklı, Z. A. (2022). Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors. Avrupa Yaşam Bilimleri Dergisi, Volume: 1 Issue: 1. https://doi.org/10.55971/EJLS.1089254

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