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Journals / Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi / 2022 / Cilt: 1 Sayı: 3

Correlation of maternal blood, cord blood and placental tissue malondialdehyde levels with fetomaternal Doppler values in preeclamptic pregnant women

Preeklamptik gebelerde maternal kan, kordon kanı ve plasental dokuda Malondialdehit düzeylerinin fetomaternal Doppler değerleri ile korelasyonu

Esra Çınar Tanrıverdi(Atatürk Üniversitesi)0000-0001-8857-3986
H. Alper Tanriverdi(ADNAN MENDERES UNIVERSITY)0000-0003-2559-5509
Ayşe Semra Demir Akça(BULENT ECEVIT UNIVERSITY)0000-0002-2092-656X
Pages
89–96
Publication Date
2022-12-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, no significant correlation was found between MDA levels and Doppler values.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim In this study, it was aimed to evaluate the correlation of malondialdehyde (MDA) levels in maternal blood, fetal blood and placental bed with fetomaternal Doppler values in preeclamptic pregnant women.
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Key Findings & Data:Material and Methods The study was carried out with a total of 74 cases, 52 of whom were healthy and 22 were pregnant with preeclampsia.MDA levels were measured in maternal blood, cord blood and placenta tissues of the pregnant women.
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Conclusion & Impact:However, no significant correlation was found between MDA levels and Doppler values.
🔬Design:Klinik Araştırma
📍Scope:Comprehensive Sample
⚙️Variables:Oksidatif stres · lipid peroksidasyonu · malondialdehit

Abstract

Aim In this study, it was aimed to evaluate the correlation of malondialdehyde (MDA) levels in maternal blood, fetal blood and placental bed with fetomaternal Doppler values in preeclamptic pregnant women. Material and Methods The study was carried out with a total of 74 cases, 52 of whom were healthy and 22 were pregnant with preeclampsia.MDA levels were measured in maternal blood, cord blood and placenta tissues of the pregnant women. Doppler sonographic measurements were made in the uterine and umbilical arteries. Doppler values and MDA levels of preeclamptic and healthy pregnant women were compared. Results MDA levels in maternal blood and placental tissue in preeclamptic pregnant women were significantly higher than healthy pregnant women (p 0.05). Doppler sonographic indexes in the umbilical and uterine arteries were significantly higher in the preeclamptic group than in the control group (p<0.05). When all patients were evaluated, there was no significant correlation between maternal and placental malondialdehyde values and umbilical and uterine artery Doppler values. Conclusion MDA levels and fetomaternal Doppler values in blood and placental tissue were significantly higher in preeclamptic pregnants compared to the control group. However, no significant correlation was found between MDA levels and Doppler values.

Özet

Amaç Bu çalışmada preeklamptik gebelerde maternal kan, fetal kan ve plasental yataktaki malondialdehit (MDA) düzeylerinin fetomaternal Doppler değerleri ile korelasyonunun değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem Çalışma 52 sağlıklı, 22 preeklamptik gebe olmak üzere toplam 74 olgu ile yürütülmüştür. Gebelerin maternal kan, kordon kanı, plasenta dokularında MDA düzeyleri ölçüldü. Uterin ve umbilikal arterlerde Doppler sonografik ölçümler yapıldı. Preeklamptik ve sağlıklı gebelerin Doppler değerleri ile MDA düzeyleri karşılaştırıldı. Veriler SPSS programında analiz edildi. İstatistiksel anlamlılık düzeyi p 0.05). Umbilikal arter ve uterin arterlerdeki Doppler sonografik indeksler, preeklamptik grupta kontrol grubuna göre anlamlı şekilde daha yüksekti (p<0.05). Tüm hastalar değerlendirildiğinde maternal ve plasental malondialdehit değerleri ile umbilikal ve uterin arter Doppler değerleri arasında anlamlı bir korelasyon saptanmadı. Sonuç Preeklamptik gebelerde, kan ve plasental dokudaki MDA düzeyleri ve fetomaternal Doppler değerleri kontrol grubuna göre anlamlı şekilde daha yüksek bulunmuş, ancak MDA düzeyleri ile Doppler değerleri arasında anlamlı bir korelasyon saptanmamıştır.

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Cite This Article

Tanrıverdi, E. Ç., Tanriverdi, H. A., Akça, A. S. D. (2022). Correlation of maternal blood, cord blood and placental tissue malondialdehyde levels with fetomaternal Doppler values in preeclamptic pregnant women. Atatürk Üniversitesi Tıp Fakültesi Cerrahi Tıp Bilimleri Dergisi, Cilt: 1 Sayı: 3, 89–96. https://ajindex.com/articles/1609814

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