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Journals / Türk Jinekolojik Onkoloji Dergisi / 2026 / Cilt: 24 Sayı: 2

The relationship between serum adropin levels, body mass index and blood pressure values in endometrial carcinoma

Endometrial karsinomda serum adropin düzeyleri, vücut kitle indeksi ve kan basıncı değerleri arasındaki ilişki

Cihat Murat Alınca(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL ZEYNEP KAMİL HEALTH RESEARCH CENTER FOR GYNAECOLOGY AND PEDIATRICS, DEPARTMENT OF SURGICAL MEDICAL SCIENCES)
Esra Keles(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL KARTAL DR. LÜTFİ KIRDAR HEALTH RESEARCH CENTER)0000-0001-8099-8883
Uğur Kemal Öztürk(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL ZEYNEP KAMİL KADIN VE ÇOCUK HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ)
Ayşe Ender Yumru(ISTANBUL OKAN UNIVERSITY)
Pages
44–53
Publication Date
2024-08-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Adropin may be a promising marker for the differential diagnosis of type 1 and type 2 endometrial carcinoma before surgery and needs to be confirmed by further studies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Adropin is a protein that has been found in the brain, liver, and peripheral tissues in terms of energy homeostasis.
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Key Findings & Data:Material and Methods: Fourty healthy and 50 EC patients’ demographic information, including characteristics of obstetric history, diabetes mellitus (DM), hypertension (HT), and family history were recorded.
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Conclusion & Impact:Conclusion: Adropin may be a promising marker for the differential diagnosis of type 1 and type 2 endometrial carcinoma before surgery and needs to be confirmed by further studies.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Adropin · Vücut Kitle İndeksi · Kan Basıncı

Abstract

Aim: Adropin is a protein that has been found in the brain, liver, and peripheral tissues in terms of energy homeostasis. Serum adropin levels were lower in hypertension, diabetes mellitus, and metabolic syndrome. This study aimed to investigate the relationship between adropin levels, body mass index (BMI), and blood pressure values in endometrial carcinoma (EC). Material and Methods: Fourty healthy and 50 EC patients’ demographic information, including characteristics of obstetric history, diabetes mellitus (DM), hypertension (HT), and family history were recorded. Fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG), and adropin levels were obtained from venous blood samples. Results: We found no statistically significant difference between the control and EC groups at the serum adropin level. However, adropin was found to be significantly lower in type 2 EC (OR=0.350; 95%CI 0.156-0.783; p=0.011). Optimal cut-off value was calculated in ROC curve analysis as 0.4 ng/mL for adropin (63.6% sensitivity, 64.7% specificity). Positive Likelihood ratio (LR+) was 1.8 and the negative Likelihood ratio (LR-) was 0.56. Conclusion: Adropin may be a promising marker for the differential diagnosis of type 1 and type 2 endometrial carcinoma before surgery and needs to be confirmed by further studies.

Özet

Amaç: Adropin, enerji homeostazı açısından beyin, karaciğer ve periferik dokularda bulunan bir proteindir. Serum adropin düzeyleri hipertansiyon, diabetes mellitus ve metabolik sendromda daha düşük bulunmuştur. Bu çalışmanın amacı endometriyal karsinomlu (EC) hastalarda adropin düzeyleri, vücut kitle indeksi (VKİ) ve kan basıncı değerleri arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntemler: Toplam 40 sağlıklı ve 50 EC hastanın obstetrik öykü, diabetes mellitus (DM), hipertansiyon (HT) ve aile öyküsü özelliklerini içeren demografik bilgileri kaydedildi. Venöz kan örneklerinden açlık insülini, insülin direnci için homeostaz modeli değerlendirmesi (HOMA-IR), yüksek yoğunluklu lipoprotein (HDL), düşük yoğunluklu lipoprotein (LDL), total kolesterol (TK), trigliserit (TG) ve adropin düzeyleri elde edildi. Bulgular: Kontrol ve EC grupları arasında serum adropin düzeyi açısından istatistiksel olarak anlamlı bir fark bulunmamıştır. Ancak tip 2 EC’de adropin anlamlı derecede düşük bulunmuştur (OR=0,350; %95CI 0,156-0,783; p=0,011). ROC eğrisi analizinde adropin için optimum cut-off değeri 0,4 ng/mL olarak hesaplanmıştır (%63,6 duyarlılık, %64,7 özgüllük). Pozitif Olabilirlik oranı (LR+) 1,8 ve negatif Olabilirlik oranı (LR-) 0,56 olarak hesaplanmıştır. Sonuç: Adropin, cerrahi öncesi tip 1 ve tip 2 endometriyal karsinomun ayırıcı tanısı için umut verici bir belirteç olabilir ve daha ileri çalışmalarla doğrulanması gerekmektedir.

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Cite This Article

Alınca, C. M., Keles, E., Öztürk, U. K., Yumru, A. E. (2024). The relationship between serum adropin levels, body mass index and blood pressure values in endometrial carcinoma. Türk Jinekolojik Onkoloji Dergisi, Cilt: 24 Sayı: 2, 44–53. https://ajindex.com/articles/1603012

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