Journals / Tıp Fakültesi Klinikleri Dergisi / 2024 / Cilt: 7 Sayı: 3

Recent Insights into Diagnostic Biomarkers and Prognostic Factors in Acute Cholecystitis

Akut Kolesistitte Tanısal Biyobelirteçler ve Prognostik Faktörlere İlişkin Son Bilgiler

Abuzer Özkan(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL BAĞCILAR HEALTH RESEARCH CENTER)0000-0003-4284-0086
Ahmet Taha Özatak(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAĞCILAR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-1848-4077
Pages
145–147
Publication Date
2024-11-15
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, these findings contribute to the ongoing efforts to optimize diagnostic strategies and improve patient outcomes in the management of AC.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The diagnostic and prognostic evaluation of acute cholecystitis (AC) is a multifaceted process that involves the integration of clinical presentation, laboratory findings, and imaging techniques.
📊
Key Findings & Data:Biomarkers such as PTX3 and visfatin have emerged as promising indicators for disease severity and prognosis, offering potential insights into the management and treatment of AC.
💡
Conclusion & Impact:Overall, these findings contribute to the ongoing efforts to optimize diagnostic strategies and improve patient outcomes in the management of AC.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Akut kolesistit · ciddiyet · biyobelirteç

Abstract

The diagnostic and prognostic evaluation of acute cholecystitis (AC) is a multifaceted process that involves the integration of clinical presentation, laboratory findings, and imaging techniques. Biomarkers such as PTX3 and visfatin have emerged as promising indicators for disease severity and prognosis, offering potential insights into the management and treatment of AC. The studies reviewed underscore the importance of early and accurate diagnosis in guiding appropriate therapeutic interventions and minimizing the risk of complications. Further research into the utility of biomarkers like PTX3 and visfatin may enhance our understanding of AC pathophysiology and facilitate personalized approaches to patient care. Overall, these findings contribute to the ongoing efforts to optimize diagnostic strategies and improve patient outcomes in the management of AC.

Özet

Akut kolesistitin (AK) tanısal ve prognostik değerlendirmesi, klinik tablonun, laboratuvar bulgularının ve görüntüleme tekniklerinin entegrasyonunu içeren çok yönlü bir süreçtir. PTX3 ve visfatin gibi biyobelirteçler, hastalığın ciddiyeti ve prognozu için umut verici göstergeler olarak ortaya çıkmış ve AK'nin yönetimi ve tedavisine ilişkin potansiyel bilgiler sunmaktadır. Gözden geçirilen çalışmalar, uygun terapötik müdahalelerin yönlendirilmesinde ve komplikasyon riskinin en aza indirilmesinde erken ve doğru tanının öneminin altını çizmektedir. PTX3 ve visfatin gibi biyobelirteçlerin kullanımına ilişkin daha fazla araştırma, AK patofizyolojisi konusundaki anlayışımızı geliştirebilir ve hasta bakımına kişiselleştirilmiş yaklaşımları kolaylaştırabilir. Genel olarak, bu bulgular AK yönetiminde tanı stratejilerini optimize etme ve hasta sonuçlarını iyileştirme yönünde devam eden çabalara katkıda bulunmaktadır.

🔖

Cite This Article

Özkan, A., Özatak, A. T. (2024). Recent Insights into Diagnostic Biomarkers and Prognostic Factors in Acute Cholecystitis. Tıp Fakültesi Klinikleri Dergisi, Cilt: 7 Sayı: 3, 145–147. https://ajindex.com/articles/1602092

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Gürlevik E, Akça HŞ, Akça MT, et al. The role of the De Ritis ratio in acute cholecystitis: a retrospective observational study. J Contemp Med. 2023;13(3):388-395. doi:10.16899/jcm.1210142.
  2. Ozkan A, Ozsivri K, Algin A, et al. Can the blood urea nitrogen to serum albumin ratio predict a prolonged hospital stay in patients with acute cholecystitis? Ann Med Res. 2023;30(8):914-919. Doi:10.5455/annalsmedres. 2023.06.132.
  3. Özdemir S, Altunok İ, Özkan A et al. The role of the hematological inflammatory index and systemic immuno-inflammation index in acute cholecystitis. Eur J Clin Exp Med 2022;20(3):330-5. Doi: 10.15584/ejcem. 2022.3.11.
  4. Çoban S, Akkurt G, Ulusoy S, et al. An investigation into the clinical efficacy of thiol/disulfide hemostasis and ischemiamodified albumin in cases of gallbladder perforation. Ulus Travma Acil Cerrahi Derg 2021;27:192-199. Doi: 10.14744/ tjtes.2020.03539.
  5. Gul E, Gul Y, Ozkan Z, et al. The Effectiveness of Ischemia Modified Albumin in Determining Acute Cholecystitis and its Severity. Clin Lab. 2021 Sep 1;67(9). doi: 10.7754/Clin.Lab.2021.210116.
  6. Alyar G, Öztürk Ez. Visfatin as a Promising Marker of Metabolic Risk. International Journal of PharmATA 2022;2(3):87–90.
  7. Park JW, Kim OH, Lee SC, et al. Serum level of visfatin can reflect the severity of inflammation in patients with acute cholecystitis. Ann Surg Treat Res. 2020 Jul;99(1):26-36. doi: 10.4174/astr.2020.99.1.26.
  8. Xie KG, Teng XP, Zhu SY, et al. Elevated plasma visfatin levels correlate with conversion of laparoscopic cholecystectomy to open surgery in acute cholecystitis. Peptides. 2014 Oct;60:8-12. doi: 10.1016/j. peptides.2014.07.017.
  9. Algin A, Gulacti U, Inan İ, et al. Relationship between serum Pentraxin 3 and pro-adrenomedullin levels with acute cholecystitis. Am J Emerg Med. 2019 Jul;37(7):1268- 1272. doi: 10.1016/j.ajem.2018.09.024.
  10. Aksungur N, Özoğul B, Öztürk N, et al. Prognostic importance of pentraxin 3 levels in acute cholesistitis. Ulus Travma Acil Cerrahi Derg. 2015 Sep;21(5):380-4. doi: 10.5505/tjtes.2015.38839.