Journals / Bezmiâlem Science / 2016 / Cilt: 4 - Sayı: 1

The Efficacy of Alendronate Treatment in Ambulatory Stroke Patients

Ambulatuar İnme Hastalarında Alendronat Tedavisinin Etkinliği

Pages
1–4
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Alendronate treatment may have a beneficial effect on the hemiosteoporosis of ambulatory stroke patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Hip fracture is a serious complication that occurs after stroke.
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Key Findings & Data:The incidence of hip fracture in stroke patients is 2-4 times higher than that in normal people and most of these fractures occur on the paretic side.
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Conclusion & Impact:Conclusion: Alendronate treatment may have a beneficial effect on the hemiosteoporosis of ambulatory stroke patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Hip fracture is a serious complication that occurs after stroke. The incidence of hip fracture in stroke patients is 2-4 times higher than that in normal people and most of these fractures occur on the paretic side. A significant bone loss on the paretic side of stroke patients has been reported. The aim of this study was to evaluate the efficacy of alendronate therapy in ambulatory stroke patients. Methods: Ambulatory stroke patients who have been followed in the outpatient clinic (n=20) were enrolled in the study. Their bone mineral density (BMD) values and laboratory parameters were retrospectively evaluated according to the medications given for osteoporosis. The analysis was performed by comparing the results of patients who had been given (Group 1) and not given (Group 2) bisphosphonate (alendronate) for a one-year period. Results: Measurements performed after a one year interval revealed that the BMD values of lumbar region and paretic and nonparetic femur neck were increased in Group 1, whereas these values were decreased in Group 2. However, when the drug use was considered, the changes were statistically significant only for the lumbar region (p=0.004). Conclusion: Alendronate treatment may have a beneficial effect on the hemiosteoporosis of ambulatory stroke patients.

Özet

Amaç: Kalça kırığı inmeden sonra görülen ciddi bir komplikasyondur. Kalça kırığının insidansı inme hastalarında normal populasyondan 2-4 kat fazladır ve bu kırıkların çoğu paretik tarafta olur. İnme hastalarında paretik tarafta ciddi bir kemik kaybı olduğu bildirilmiştir. Bu çalışmanın amacı ambulatuar inme hastalarında alendronat tedavisinin etkinliğini değerlendirmektir.Yöntemler: Polikliniğimizden takip edilen ambulatuar inme hastaları (n=20) çalışmaya alındı. Kemik mineral yoğunluğu (KMY) değerleri ve laboratuvar parametreleri retrospektif olarak değerlendirildi. Bir yıl boyunca bifosfonat (alendronat) verilen (Grup 1) ve verilmeyen (Grup 2) hastaların verileri karşılaştırılarak analizler yapıldı. Bulgular: Bir yıl arayla yapılan ölçümlerde lomber bölge, paretik ve nonparetik femur boynu KMY değerleri Grup 1'de artarken Grup 2'de azalmıştı. Ama ilaç kullanımı göz önüne alındığında bu değişiklikler sadece lomber bölgede istatistiksel olarak anlamlıydı (p=0,004).Sonuç: Alendronat tedavisinin ambulatuar inme hastalarında görülen hemiosteoporozlu hastalarda yararlı etkileri olabilir.

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Cite This Article

ÖZARAS, N., DEMİR, S. E., ARSLAN, A. (2016). The Efficacy of Alendronate Treatment in Ambulatory Stroke Patients. Bezmiâlem Science, Cilt: 4 - Sayı: 1, 1–4. https://ajindex.com/articles/160030

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