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Journals / Journal of Human Rhythm / 2026 / Cilt: 1 Sayı: 3

Colon Adenocarcinoma With Orbital Metastasis

Esin Oktay
Özgür Tanrıverdi
Sabri Barutça
Nezih Meydan
Pages
107–110
Publication Date
2015-12-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The disease has poor prognosis due to dissemination of the systemic cancer.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Orbital metastasis in solid tumors, especially in colon adenocarcinomas, is very rare and its management is a real challenge in clinical oncology.
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Key Findings & Data:Here, we report a 60-year-old woman with stage IV colon adenocarcinoma, who was admitted with ophthalmic complaints while under systemic chemotherapy.
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Conclusion & Impact:The disease has poor prognosis due to dissemination of the systemic cancer.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Orbital metastasis in solid tumors, especially in colon adenocarcinomas, is very rare and its management is a real challenge in clinical oncology. Here, we report a 60-year-old woman with stage IV colon adenocarcinoma, who was admitted with ophthalmic complaints while under systemic chemotherapy. The patient had conjunctival chemosis, severe exophthalmos, ptosis, and limitation of movement on the left eye. Magnetic resonance imaging revealed a 35x21 mm soft tissue mass in the left orbita. The patient refused further treatment and was released in 15 days. The treatment of metastatic orbital tumors is often multidisciplinary; combining local treatments (surgery and radiotherapy), systemic treatments (chemotherapy, biological and hormonal therapies), and palliative approaches (mainly based on corticosteroids) together. The disease has poor prognosis due to dissemination of the systemic cancer.

Özet

Orbital metastaz tüm solid tümörlerde, özellikle de kolon adenokarsinomunda oldukça nadir bir durumdur ve yönetimi klinik onkolojide gerçek bir sorundur. Biz bu yazıda 60 yaşında, evre IV kolon adenokarsinomu tanısı olan ve sistemik kemoterapi altında oftalmik şikayetler ile başvuran kadın hastayı bildiriyoruz. Hastanın sol gözünde konjonktival kemozis, şiddetli egzoftalmi, pitozis ve hareket kısıtlılığı vardı. Manyetik rezonans görüntüleme sol orbita bir 35x21 mm’lik yumuşak doku kitlesi saptandı. Sunulan olgu ileri tedaviyi reddetti ve 15 gün içinde eksitus oldu. Orbital metastatik tümörlerin tedavisi; lokal tedaviler (cerrahi ve radyoterapi), sistemik tedaviler (kemoterapi, biyolojik ve hormonal tedaviler) ve palyatif yöntemlerin (kortikosteroid temelli tedaviler) birlikte katılımı ile multidisipliner olarak yapılmalıdır ancak hastalığın yaygın hale gelmiş olması sebebiyle hastalık kötü prognozludur.

Keywords
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Cite This Article

Oktay, E., Tanrıverdi, Ö., Barutça, S., Meydan, N. (2015). Colon Adenocarcinoma With Orbital Metastasis. Journal of Human Rhythm, Cilt: 1 Sayı: 3, 107–110. https://ajindex.com/articles/1592544

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References (53)

  1. Amemiya T, Hayashida H, Dake Y. Metastatic orbital tumors in Japan: a
  2. review of the literature. Ophthalmic Epidemiol. 2002;9 (1):35-47.
  3. Valenzuela AA, Archibald CW, Fleming B, Ong L, O'Donnell B, Crompton
  4. J J, et al. Orbital metastasis: clinical features, management and outcome.
  5. Orbit. 2009;28 (2-3):153-9.
  6. Ferry A, Font R. Carcinoma metastatic to the eye and orbit: a
  7. clinicopathological study of 227 cases. Arch Ophthalmol. 1974 Oct;92 (4):276-86.
  8. García-Fernández M, Castro-Navarro J, Saiz-Ayala A, Álvarez-Fernández
  9. C. Orbital metastases in colorectal cancer: a case report. Arch Soc Esp
  10. Oftalmol. 2012;87 (7):216-9.
  11. Tunc M. Current Diagnostic and Management Methods in Orbital Tumors.
  12. Turk J Ophthalmol 2014;44 (Özel Sayı): 1-7
  13. S. B. Rudoler MD, C. L. Shields MD, J. A. Shields MD. Radiation Therapy
  14. of Uveal and Orbital Metastases. Radiotherapy of Intraocular and Orbital
  15. Tumors Medical Radiology 2003, pp 87-93.
  16. Demirci H, Shields CL, Chao AN, Shields JA. Uveal metastasis from breast
  17. cancer in 264 patients. Am J Ophthalmol. 2003;136 (2):264-71.
  18. Koma Y, Goto K, Yoshida C, Kimura K, Matsumoto Y, Koyama M, et al.
  19. Orbital metastasis secondary to pulmonary adenocarcinoma treated with
  20. gefitinib: a case report. J Med Case Rep. 2012;18 (6):353.
  21. Saitoh A., Amemia T., Tsuda N. Metatases of breast carcinoma to eyelid and
  22. orbid of a postmenapausal women; good respons to tamoxifen therapy.
  23. Ophthalmologica. 1997;211 (6):362-6.
  24. El Mejjad A, Jouhadi H, Fekak H, Rabii R, Bennani S, Benider A, et al. Orbital
  25. metastasis of prostatic carcinoma. Prog Urol. 2005;15 (1):85-8.
  26. Papageorgiou KI, Sinha A, Ioannidis AS, Davidson NG. Ocular metastases
  27. from HER2 positive breast carcinoma and the response to combination
  28. therapy with Paclitaxel and Trastuzumab: A case report. Cases J. 2009;4
  29. :9143.
  30. Wong ZW, Phillips SJ, Ellis MJ. Dramatic response of choroidal metastases
  31. from breast cancer to a combination of trastuzumab and vinorelbine. Breast
  32. J. 2004;10 (1):54-6.
  33. Ju UH, Tsai ML, Lin CS, Chao TY, Dai MS. Lapatinib and platinum-based
  34. chemotherapy ameliorate breast cancer with choroidal metastasis and
  35. restore visual acuity. Tumori. 2014;100 (3):e67-9.
  36. Ngo E, Hutchins LF, Gardner JM, Uwaydat SH. Regression of orbital and
  37. choroidal metastases from melanoma after treatment with vemurafenib.
  38. Can J Ophthalmol. 2014;49 (2):e49-52.
  39. Yin VT, Pfeiffer ML, Esmaeli B. Targeted Therapy for Orbital and Periocular
  40. Basal Cell Carcinoma and Squamous Cell Carcinoma. Ophthal Plast Reconstr Surg. 2013;29 (2):87-92.
  41. review of the literature. Ophthalmic Epidemiol. 2002;9 (1):35-47.
  42. Orbit. 2009;28 (2-3):153-9.
  43. Oftalmol. 2012;87 (7):216-9.
  44. Turk J Ophthalmol 2014;44 (Özel Sayı): 1-7
  45. cancer in 264 patients. Am J Ophthalmol. 2003;136 (2):264-71.
  46. gefitinib: a case report. J Med Case Rep. 2012;18 (6):353.
  47. Ophthalmologica. 1997;211 (6):362-6.
  48. metastasis of prostatic carcinoma. Prog Urol. 2005;15 (1):85-8.
  49. :9143.
  50. J. 2004;10 (1):54-6.
  51. restore visual acuity. Tumori. 2014;100 (3):e67-9.
  52. Can J Ophthalmol. 2014;49 (2):e49-52.
  53. Basal Cell Carcinoma and Squamous Cell Carcinoma. Ophthal Plast Reconstr Surg. 2013;29 (2):87-92.