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Journals / Veterinary Sciences and Practices / 2020 / Cilt: 15 Sayı: 3

The Effect of Resveratrol on The Oxidative Stress in Rats Treated with Irradiation

Radyasyona Maruz Kalan Ratlarda Oksidatif Stres Üzerine Resveratrolün Etkisi

Mehtap Özçelik(FIRAT ÜNİVERSİTESİ)0000-0003-2362-4935
Mine Erişir(FIRAT ÜNİVERSİTESİ)0000-0001-6209-4792
Osman Güler(MUNZUR ÜNİVERSİTESİ)0000-0001-8225-1505
Murat Baykara(FIRAT ÜNİVERSİTESİ)0000-0003-2588-9013
Funda Gülcü(FIRAT ÜNİVERSİTESİ)0000-0002-2514-4559
Pages
294–300
Publication Date
2020-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the data obtained as a result; It was concluded that resveratrol shows a corrective effect by changing the oxidant/antioxidant balance against oxidative stress caused by irradiation, therefore resveratrol is a powerful antioxidant.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The antioxidant and protective effect of resveratrol against irradiation induced oxidative damage were researched.
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Key Findings & Data:Twenty-one rats were seperated into 3 groups; First group was the control group.
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Conclusion & Impact:According to the data obtained as a result; It was concluded that resveratrol shows a corrective effect by changing the oxidant/antioxidant balance against oxidative stress caused by irradiation, therefore resveratrol is a powerful antioxidant.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Resveratrol · Radyasyon · Oksidatif stres

Abstract

The antioxidant and protective effect of resveratrol against irradiation induced oxidative damage were researched. Twenty-one rats were seperated into 3 groups; First group was the control group. Second group was the irradiation group; received physiological saline intraperitoneally (i.p.) for three days, then 9 Gray (Gy) irradiation was applied. Third group was irradiation+Resveratrol group; received 10 mg/kg resveratrol i.p. for three days and then the same dose of radiation was applied. As a result of irradiation, a significant increase was found in the level of malondialdehyde (MDA) in the liver, kidney and brain tissues of rats (P˂0.001). Glutathione peroxidase (GSH-Px) activity in all the tissues and superoxide dismutase (SOD) activity, Glutathione (GSH) levels in liver decreased (P˂0.01), GSH levels in kidney, spleen and ovarium tissues significantly increased (P˂0.05). The giving of resveratrol significantly reduced the MDA levels increasing in liver, kidney, and brain as a result of irradiation (P˂0.001) and the liver MDA levels reached to the control levels. By giving resveratrol, it was determined that all the antioxidants studied reduced significantly compared to the control group and/or the irradiation group (P˂0.05). According to the data obtained as a result; It was concluded that resveratrol shows a corrective effect by changing the oxidant/antioxidant balance against oxidative stress caused by irradiation, therefore resveratrol is a powerful antioxidant.

Özet

Radyasyonun yarattığı oksidatif hasar üzerine resveratrolün antioksidan ve koruyucu etkisi araştırıldı. Yirmi bir rat 3 gruba ayrıldı; Birinci grup, Kontrol grubu. İkinci grup, Radyasyon grubu; Üç gün fizyolojik tuz solüsyonu intraperitoneal (i.p.) olarak verildi ve sonra 9 Gray (Gy) radyasyon uygulandı. Üçüncü grup, Radyasyon + Resveratrol grubu; Üç gün 10 mg/kg olacak şekilde resveratrol i.p. verildi ve sonra aynı dozda radyasyon uygulandı. Radyasyon sonucu ratların karaciğer, böbrek ve beyin dokularında malondialdehit (MDA) seviyesinde önemli artış saptandı (P˂0.001). Çalışılan tüm dokularda glutatyon peroksidaz (GSH-Px) aktivitesinde (P˂0.01), yine karaciğer süperoksit dismutaz (SOD) aktivitesi ve glutatyon (GSH) seviyesinde azalış (P˂0.01), böbrek, dalak ve ovarium dokularında GSH düzeyinde ise önemli artış tespit edildi (P˂0.05). Resveratrol verilmesi radyasyon sonucu karaciğer, böbrek ve beyinde artan MDA düzeylerini önemli azalttı (P˂0.001) ve karaciğer MDA düzeyleri kontrol düzeylerine ulaştı. Resveratrol verilmesiyle çalışılan tüm antioksidanların kontrol ve/veya radyasyon uygulanan gruba göre önemli azalma gösterdiği tespit edildi (P˂0.05). Sonuç olarak elde edilen verilere göre; resveratrolün radyasyona bağlı oluşan oksidatif strese karşı oksidan/antioksidan dengeyi değiştirerek düzeltici bir etki gösterdiği, bu nedenle resveratrolün güçlü bir antioksidan olduğu kanaatine varılmıştır.

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Cite This Article

Özçelik, M., Erişir, M., Güler, O., Baykara, M., Gülcü, F. (2020). The Effect of Resveratrol on The Oxidative Stress in Rats Treated with Irradiation. Veterinary Sciences and Practices, Cilt: 15 Sayı: 3, 294–300. https://doi.org/10.17094/ataunivbd.721994

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