Journals / Çocuk Acil ve Yoğun Bakım Dergisi / 2017 / Cilt: 4 - Sayı: 1

The Effect of Carbon Monoxide Poisoning on Platelet Volume in Children

Çocuklarda Karbonmonoksit Zehirlenmesinin Ortalama Trombosit Hacmi Üzerine Etkisi

Pages
13–16
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The difference between the MPV values and the lack of significance and the absence of correlation between MPV value and COHb level led to the fact that MPV was not a guide indicating the clinical severity of the condition.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Carbon monoxide poisoning is one of the most important causes of morbidity and mortality.
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Key Findings & Data:Methods: We retrospectively evaluated children who were diagnosed with carbon monoxide poisoning in our hospital between January 2005 and 2014.
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Conclusion & Impact:The difference between the MPV values and the lack of significance and the absence of correlation between MPV value and COHb level led to the fact that MPV was not a guide indicating the clinical severity of the condition.
🔬Design:Research Article
📍Scope:2005 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: Carbon monoxide poisoning is one of the most important causes of morbidity and mortality. There is increasing evidence supporting the important role of mean platelet volume (MPV) as a marker of hypoxia and inflammation. In this study, we aimed to determine changes in MPV values in pediatric patients with carbon monoxide poisoning. Methods: We retrospectively evaluated children who were diagnosed with carbon monoxide poisoning in our hospital between January 2005 and 2014. Results: We included 228 children with carbon monoxide poisoning (49% male) in this retrospective, controlled study. The mean age of the patients was 88±56 months. Control group consisted of 200 age-matched healthy children. There was no statistically significant difference in MPV levels between the study and control groups (8.43±1.1 fL and 8.26±0.7 fL, respectively). No correlation of MPV and platelet count with carboxyhemoglobin (COHb) was found.Conclusion: In our study, it was determined that MPV value was not a helpful parameter for predicting the diagnosis of acute carbon monoxide poisoning in childhood. The difference between the MPV values and the lack of significance and the absence of correlation between MPV value and COHb level led to the fact that MPV was not a guide indicating the clinical severity of the condition.

Özet

Amaç: Karbonmonoksit zehirlenmesi önemli bir morbidite ve mortalite nedenidir. Ortalama trombosit hacminin (MPV) hipoksi ve enflamasyonun belirteci olabileceği yönündeki görüşler artmaktadır. Bu çalışmada karbonmonoksit zehirlenmesi olan çocuk hastalarda ki MPV değeri değişiminin saptanması amaçlanmıştır.Yöntemler: Hastanemizde Ocak 2005-2014 tarihleri arasında karbonmonoksit zehirlenmesi tanısı alan çocuk hastalar geriye dönük olarak incelendi. Bulgular: Çalışmaya alınan 228 hastanın (%49 erkek) ortalama yaşı 88±56 aydı. Kontrol grubu için benzer yaş aralığında olan 200 sağlıklı çocuk seçildi. MPV değeri çalışma grubunda 8,43±1,1 fL, kontrol grubunda 8,26±0,7 fL idi, arada anlamlı istatistiksel fark bulunamadı. Karboksihemoglobin (COHb) değeri ile MPV değeri ve trombosit sayısı arasında da korelasyon saptanmadı. Sonuç: Çalışmamızda çocukluk çağında MPV değerinin akut karbonmonoksit zehirlenmesi tanısını öngörmede yardımcı bir parametre olmadığı saptanmıştır. Hastaların MPV değerlerinin bulgulara göre karşılaştırıldığında anlamlı fark bulunmaması ve MPV değeri ile COHb seviyesi arasında korelasyon saptanmamış olması nedeniyle, MPV'nin hastalığın klinik şiddeti hakkında yol gösterici olmadığı sonucuna varılmıştır.

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Cite This Article

AKÇA, H., ÜREL, G., KARACAN, C. D., TUYGUN, N., POLAT, E. (2017). The Effect of Carbon Monoxide Poisoning on Platelet Volume in Children. Çocuk Acil ve Yoğun Bakım Dergisi, Cilt: 4 - Sayı: 1, 13–16. https://ajindex.com/articles/157670

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