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Journals / Uşak Üniversitesi Fen ve Doğa Bilimleri Dergisi / 2025 / Cilt: 9 Sayı: 2

Cytotoxic and Genotoxic Potential of Hibiscus sabdariffa

Hibiscus sabdariffa'nın Sitotoksik ve Genotoksik Potansiyeli

Mualla Dursun(YOZGAT BOZOK UNIVERSITY)0009-0001-3257-4821
Halil Erhan Eroğlu(YOZGAT BOZOK ÜNİVERSİTESİ)0000-0002-4509-4712
Pages
171–175
Publication Date
2025-12-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, it is important to avoid using the herb in high concentrations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hibiscus sabdariffa L., also known as Roselle, has widespread use for medicinal and nutritional purposes.
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Key Findings & Data:All concentrations and application periods of Hibiscus sabdariffa extracts decreased the mitotic index and increased the chromosomal defects compared to the control.
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Conclusion & Impact:Therefore, it is important to avoid using the herb in high concentrations.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Allium testi · Hibiscus · toksik etki

Abstract

Hibiscus sabdariffa L., also known as Roselle, has widespread use for medicinal and nutritional purposes. It is important to detect its toxic potential due to its beneficial uses in food and beverage, health, cosmetics, etc. The aim of this study was to evaluate the cytotoxic and genotoxic potential of Hibiscus sabdariffa by Allium test. All concentrations and application periods of Hibiscus sabdariffa extracts decreased the mitotic index and increased the chromosomal defects compared to the control. These effects were statistically significant at 0.5 mg/mL (p˂0.05). The mitotic and chromosomal defects can pave the way for the development of genetic diseases such as cancer, as well as leading to the loss of cell functions and death mechanisms such as apoptosis. Therefore, it is important to avoid using the herb in high concentrations.

Özet

Roselle olarak da bilinen Hibiscus sabdariffa L., tıbbi ve beslenme amaçlı yaygın olarak kullanılır. Gıda ve içecek, sağlık, kozmetik vb. alanlardaki yararlı kullanımları nedeniyle toksik potansiyelinin tespit edilmesi önemlidir. Bu çalışmanın amacı, Hibiscus sabdariffa'nın sitotoksik ve genotoksik potansiyelini Allium testi ile değerlendirmektir. Hibiscus sabdariffa özütlerinin tüm konsantrasyonları ve uygulama süreleri, mitotik indeksi azaltmış ve kontrol ile karşılaştırıldığında kromozomal defektleri artırmıştır. Bu etkiler 0.5 mg/mL'de istatistiksel olarak anlamlıdır (p˂0.05). Mitotik ve kromozomal defektler, kanser gibi genetik hastalıkların gelişmesine zemin hazırlayabileceği gibi, hücre fonksiyonlarının kaybına ve apoptozis gibi ölüm mekanizmalarına da yol açabilir. Bu nedenle, bitkinin yüksek konsantrasyonlarda kullanımından kaçınmak önemlidir.

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Cite This Article

Dursun, M., Eroğlu, H. E. (2025). Cytotoxic and Genotoxic Potential of Hibiscus sabdariffa. Uşak Üniversitesi Fen ve Doğa Bilimleri Dergisi, Cilt: 9 Sayı: 2, 171–175. https://doi.org/10.47137/usufedbid.1678297

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