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Journals / Turkish Journal of Veterinary Research / 2026 / Volume: 10 Issue: 1

The effect of birth weight on passive immunity transfer in kangal breed lambs

Sefer Türk(Sivas Cumhuriyet Üniversitesi)0000-0003-4683-5217
Fikri Emlik(SIVAS CUMHURIYET UNIVERSITY)0000-0002-4988-0614
Uğur Aydoğdu(BALIKESIR UNIVERSITY)0000-0002-9828-9863
Alparslan Coşkun(SIVAS CUMHURIYET UNIVERSITY)0000-0002-2242-9647
Pages
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Publication Date
2026-03-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Ensuring timely and adequate colostrum intake in lambs below the identified threshold (<4.53 kg) is imperative for mitigating immunological deficits and enhancing neonatal survival outcomes in Kangal sheep husbandry.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This study evaluates the influence of birth weight on the passive transfer of immunity (PTI) in Kangal breed lambs, a robust and economically significant Turkish sheep breed.
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Key Findings & Data:A cohort of 38 healthy neonatal lambs was assessed to elucidate the associations between birth weight and key indicators of PTI, including serum Optical Brix percentage, total protein (TP) concentration, and gamma-glutamyl transferase (GGT) enzyme activity.
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Conclusion & Impact:Ensuring timely and adequate colostrum intake in lambs below the identified threshold (<4.53 kg) is imperative for mitigating immunological deficits and enhancing neonatal survival outcomes in Kangal sheep husbandry.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Passive transfer of immunity · birth weight · colostrum

Abstract

This study evaluates the influence of birth weight on the passive transfer of immunity (PTI) in Kangal breed lambs, a robust and economically significant Turkish sheep breed. A cohort of 38 healthy neonatal lambs was assessed to elucidate the associations between birth weight and key indicators of PTI, including serum Optical Brix percentage, total protein (TP) concentration, and gamma-glutamyl transferase (GGT) enzyme activity. Blood samples were collected 48–72 hours postpartum and analyzed using cost-efficient and field-applicable methods such as refractometry, automated TP quantification, and enzymatic assays.The findings demonstrated that lambs with birth weights below 4.53 kg exhibited significantly reduced serum Brix percentages (P=0.003), TP concentrations (P=0.002), and GGT activity levels (P=0.028), indicative of compromised colostral immunoglobulin absorption. Receiver operating characteristic (ROC) analysis established 4.53 kg as the critical threshold for sufficient PTI, with optimized sensitivity and specificity values across all parameters. Birth weight exhibited a moderate to strong positive correlation with TP (R=0.351) and GGT levels (R=0.471), while Brix refractometry correlated robustly with TP (R=0.880), underscoring their diagnostic concordance. This study underscores the necessity of breed-specific PTI thresholds, particularly for breeds such as the Kangal, known for their higher mean birth weights. The findings highlight the utility of serum Brix refractometry, TP, and GGT measurements as reliable, pragmatic, and cost-effective alternatives to traditional laboratory methods for PTI assessment. Ensuring timely and adequate colostrum intake in lambs below the identified threshold (<4.53 kg) is imperative for mitigating immunological deficits and enhancing neonatal survival outcomes in Kangal sheep husbandry.

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Cite This Article

Türk, S., Emlik, F., Aydoğdu, U., Coşkun, A. (2026). The effect of birth weight on passive immunity transfer in kangal breed lambs. Turkish Journal of Veterinary Research, Volume: 10 Issue: 1. https://doi.org/10.47748/tjvr.1816644

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References (42)

  1. Ahmad R, Khan A, Javed MT, Hussain I. The level of immunoglobulins in relation to neonatal lamb mortality in Pak-Karakul sheep. Vet Arhiv. 2000; 70(3):129-139.
  2. Aydoğdu U, Şen İ, Güzelbekteş H. Methods Used in Determining of Passive Transfer Failure in Calves. Manas J Agric Vet Life Sci 2019; 9(2):104-111.
  3. Boucher Z. Breed and diet effects on ewe colostrum quality, lamb birthweight and the transfer of passive immunity. [PhD Thesis] Wagga Wagga, Australia: Charles Sturt University; 2014.
  4. Braun JP, Trumel C, Bézille P. Clinical biochemistry in sheep: A selected review. Small Rumin Res. 2010; 92(1-3):10-18.
  5. Britti D, Massimini G, Peli A, Luciani A, Boari A. Evaluation of serum enzyme activities as predictors of passive transfer status in lambs. J Am Vet Med Assoc. 2005; 226(6):951-955.
  6. Cabello G, Levieux D. Absorption of colostral IgG1 by the newborn lamb: Influence of the length of gestation, birthweight and thyroid function. Res Vet Sci. 1981; 31(2):190-194.
  7. Chniter M, Maali S, Hammadi M, et al. Effects of dam age, litter size and gender on birth weight of D'man lamb. J Arid Land Stud. 2009; 19(1):169-172.
  8. Christley RM, Morgan KL, Parkin TDH, French NP. Factors related to the risk of neonatal mortality, birthweight and serum immunoglobulin concentration in lambs in the UK. Prev Vet Med. 2003; 57(4):209-226.
  9. Deelen SM, Ollivett TL, Haines DM, Leslie KE. Evaluation of a Brix refractometer to estimate serum immunoglobulin G concentration in neonatal dairy calves. J Dairy Sci. 2014; 97(6):3838-3844.
  10. Demirtaş A, Pişkin İ. Sex differentiation in mammals and its hormonal control. Vet Hekim Der Derg. 2009; 80(3):23-28.
  11. Dwyer CM, Conington J, Corbiere F, et al. Improving neonatal survival in small ruminants: Science into practice. Animal. 2016; 10(3):449-459.
  12. Egdir C, Ocal N. Comparison of Passive Transfer Between Lambs Receiving Colostrum by Natural Suckling and Lambs Given Colostrum by Bottle.International Journal of Veterinary and Animal Research. 2023; 6(2): 39-47.
  13. Elsohaby I, McClure JT, Keefe GP. Evaluation of digital and optical refractometers for assessing failure of transfer of passive immunity in dairy calves. J Vet Intern Med. 2015; 29(2):721-726.
  14. Gardner DS, Buttery PJ, Daniel Z, Symonds ME. Factors affecting birth weight in sheep: Maternal environment. Reproduction. 2007; 133(1):297-307.
  15. Giammarco M, Chincarini M, Fusaro I, et al. Evaluation of Brix refractometry to estimate immunoglobulin G content in buffalo colostrum and neonatal calf serum. Animals. 2021; 11(9):2616.
  16. Gilbert RP, Gaskins CT, Hillers JK, Parker CF, McGuire TC. Genetic and environmental factors affecting immunoglobulin G1 concentrations in ewe colostrum and lamb serum. J Anim Sci. 1988; 66(4):855-863.
  17. Godden SM, Lombard JE, Woolums AR. Colostrum management for dairy calves. Vet Clin North Am Food Anim Pract. 2019; 35(3):535-556.
  18. Gokce E, Kirmizigul AH, Atakisi O, Kuru M, Erdogan HM. Passive immunity in lambs: Colostral and serum γ-glutamyltransferase as a predictor of IgG concentration and related to the diseases from birth to 12 weeks of life. Vet Med (Praha). 2021; 66(2):45.
  19. Gökçe E, Atakișı O, Kırmızıgül AH, Erdoğan HM. Risk factors associated with passive immunity, health, birth weight and growth performance in lambs: II. Effects of passive immunity and some risk factors on growth performance during the first 12 weeks of life. Kafkas Univ Vet Fak Derg. 2013; 19(4):619-627.
  20. Hamer K, Bellingham M, Evans NP, Jones RO, Denholm KS. Defining optimal thresholds for digital Brix refractometry to determine IgG concentration in ewe colostrum and lamb serum in Scottish lowland sheep flocks. Prev Vet Med. 2023; 218:105988.
  21. Hernandez D, Nydam DV, Godden SM, et al. Brix refractometry in serum as a measure of failure of passive transfer compared to measured immunoglobulin G and total protein by refractometry in serum from dairy calves. Vet J. 2016; 211:82-87.
  22. Hernández-Castellano LE, Suárez-Trujillo A, Martell-Jaizme D, et al. The effect of colostrum period management on BW and immune system in lambs: From birth to weaning. Animal. 2015; 9(10):1672-1679.
  23. Kandemir Ç, Taşkin T. Status of sheep breeds by regions in Turkey: Central Anatolia Region. J Anim Prod. 2022; 63(1):97-105.
  24. Kara E, Ceylan E. Failure of passive transfer in neonatal calves in dairy farms in Ankara region. Turk J Vet Anim Sci. 2021; 45(3):556-565.
  25. Kara E., Terzi OS., Şenel Y., Ceylan E. Yerli Kara ve İsviçre Esmeri Irkı Sığırların Kolostrum Kalitesinin Karşılaştırılması. F.Ü.Sağ.Bil.Vet.Derg. 2020; 32(3): 153-156.
  26. Kara H., Şenel Y. Comparison of colostrum quality between Merino and Akkaraman ewes. Turkish Journal of Veterinary Research. 2025; 9(2): 109-115.
  27. Khan A, Sultan MA, Jalvi MA, Hussain I. Risk factors of lamb mortality in Pakistan. Anim Res. 2006; 55(4):301-311.
  28. Kıvrak MB, Takcı A, Bölükbaş B, Yüksel M. The effect of vitamin and mineral supplementation on pregnancy rates in Kangal sheep during the breeding season. Eurasian J Vet Sci. 2022; 38(2):115-121.
  29. Massimini G, Britti D, Peli A, Cinotti S. Effect of passive transfer status on preweaning growth performance in dairy lambs. J Am Vet Med Assoc. 2006; 229(1):111-115.
  30. McGovern FM, McHugh N, Fitzmaurice S, et al. Phenotypic factors associated with lamb live weight and carcass composition measurements in an Irish multi-breed sheep population. Transl Anim Sci. 2020; 4(4):txaa206.
  31. Mukasa-Mugerwa E, Said AN, Lahlou-Kassi A, Sherington J, Mutiga ER. Birth weight as a risk factor for perinatal lamb mortality, and the effects of stage of pregnant ewe supplementation and gestation weight gain in Ethiopian Menz sheep. Prev Vet Med. 1994; 19(1):45-56.
  32. Nowak R, Poindron P. From birth to colostrum: Early steps leading to lamb survival. Reprod Nutr Dev. 2006; 46(4):431-446.
  33. Oldham CM, Thompson AN, Ferguson M, et al. The birthweight and survival of Merino lambs can be predicted from the profile of liveweight change of their mothers during pregnancy. Anim Prod Sci. 2011; 51(9):776-783.
  34. Pauli JV. Colostral transfer of gamma glutamyl transferase in lambs. N Z Vet J. 1983; 31(9):150-161.
  35. Sangild PT. Uptake of colostral immunoglobulins by the compromised newborn farm animal. Acta Vet Scand. 2003; 44(1):105.
  36. Sarica M, Aydoğdu U. Determination of colostrum quality using Brix refractometer in sheep. Acta Vet Hung. 2024; 72(2):116-124.
  37. Souza RS, Santos LBC, Melo IO, et al. Current diagnostic methods for assessing transfer of passive immunity in calves and possible improvements: A literature review. Animals. 2021; 11(10):2963.
  38. Şahal, M., Terzi, O.S., Ceylan, E. & Kara, E. (2018). Buzağı İshalleri ve Korunma Yöntemleri. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 58(Özel Sayı), 41-49.
  39. Resmî Gazete. Say 28240. 2012/21 sayılı Tebliğ. Available at: https://www.resmigazete.gov.tr/eskiler/2012/08/20120814-21.htm. Accessed 14, 2012.
  40. Takci A, Kivrak MB. Determination of the efficacy of human Chorionic Gonadotropin (hCG) administrations on reproductive performance, placentation, parturition, and neonatal parameters on different post–mating days in Kangal ewes sexually induced during anestrus. Revista Cientific. 2023; 33(2):1-7.
  41. Tarım ve Orman Bakanlığı. Yerli koyun ırkları. Hayvancılık Genel Müdürlüğü. Available at: https://www.tarimorman.gov.tr/HAYGEM/Belgeler/Hayvanc%C4%B1l%C4%B1k/K%C3%BC%C3%A7%C3%BCkba%C5%9F%20Hayvanc%C4%B1l%C4%B1k/Koyun%20Yeti%C5%9Ftiricili%C4%9Fi/2020%20YILI/Yerli+Koyun+Irklari.pdf. Accessed, 2020.
  42. Weaver DM, Tyler JW, VanMetre DC, Hostetler DE, Barrington GM. Passive transfer of colostral immunoglobulins in calves. J Vet Intern Med. 2000; 14(6):569-577.