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Journals / Turkish Journal of Science / 2019 / Cilt: 4 Sayı: 2

The Effect of Peripheral Adropin Application on Hypothalamic Pituitary Adrenal Axis in Rats

Mustafa Can Güler(ATATURK UNIVERSITY)0000-0001-8588-1035
Tuncer Nacar(ATATURK UNIVERSITY)0000-0002-9287-7170
Ersen Eraslan(Yozgat Bozok University)0000-0003-2424-2269
Ayhan Tanyeli(ATATURK UNIVERSITY)0000-0002-0095-0917
Elif Polat(ATATURK UNIVERSITY)0000-0003-0042-4084
Selim Çomaklı(ATATURK UNIVERSITY)0000-0002-8744-7686
Pages
60–75
Publication Date
2019-10-28
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a consequence of immunohistochemical staining, CRH has shown increase in adropin groups compared to other groups.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: Hypothalamic pituitary adrenal (HPA) axis has many missions such as responses to stress and inflammatory factors.
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Key Findings & Data:Material and Method: Thirty two (32) Wistar Albino male rats were used in the study.
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Conclusion & Impact:As a consequence of immunohistochemical staining, CRH has shown increase in adropin groups compared to other groups.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Adropin · HPA Axis · Hormone

Abstract

Purpose: Hypothalamic pituitary adrenal (HPA) axis has many missions such as responses to stress and inflammatory factors. HPA axis is the primer stress response system. Adropin is a peptid structured hormone coded by energy homeostasis related gene. In this study biochemical, histopathologic and immunohistochemical effects of adropin hormone on HPA axis were examined. Material and Method: Thirty two (32) Wistar Albino male rats were used in the study. The rats were separated into 4 equal groups (n=8). The control group did not receive any applications; and the sham group was given adropin-dissolvent. Adropin was administered as intraperitoneal to the treatment groups at doses of 4 μg/kg and 40 μg/kg. The study lasted 10 days. On the 11 th day, the animals were sacrified, and relevant tissue samples were collected. Findings: While cortisole, adrenaline, noradrenaline and serotonin levels decreased, contrary dopamin levels increased. There were no important changes on melatonin levels. As a consequence of immunohistochemical staining, CRH has shown increase in adropin groups compared to other groups.

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Cite This Article

Güler, M. C., Nacar, T., Eraslan, E., Tanyeli, A., Polat, E., Çomaklı, S. (2019). The Effect of Peripheral Adropin Application on Hypothalamic Pituitary Adrenal Axis in Rats. Turkish Journal of Science, Cilt: 4 Sayı: 2, 60–75. https://ajindex.com/articles/1557579

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