Focal Segmental Glomerulosclerosis with Sjogren Syndrome: A Case Report

Conclusion & Impact:FSGS, which is associated with sjögren's syndrome, was considered suitable for the presentation because of its rare occurrence

🔬Design:Case Report

📍Scope:Comprehensive Sample

⚙️Variables:sjogren syndrome · focal segmental glomerulosclerosis · nephrotic syndrome

Abstract

Sjogren's syndrome (SjS) is a chronic, slow-progressing, autoimmune and lymphoproliferative disease. The main symptoms of the syndrome are xerostomia and keratoconjuctivitis sicca as a result of chronic inflammatory infiltration of the salivary and lacrimal glands. Focal Segmental Glomerulosclerosis complicating primary Sjögren's syndrome is extremely rare. We report on a 39-year-old woman with 5 years history of sjogren syndrome who was found to have nephrotic syndrome. Histopathological findings in kidney biopsy compatible with focal segmental glomerulosclerosis. Steroid therapy was initiated (oral prednisolone at a dose of 15 mg/day) and Cyclosporine 2 * 100mg/d. FSGS, which is associated with sjögren's syndrome, was considered suitable for the presentation because of its rare occurrence

Keywords

sjogren syndrome focal segmental glomerulosclerosis nephrotic syndrome

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Cite This Article

Sezen, M., Yıldız, A., Dilek, K., Güllülü, M., Yavuz, M., Oruç, A., Aydın, M. F., Ersoy, A. (2021). Focal Segmental Glomerulosclerosis with Sjogren Syndrome: A Case Report. Turkish Journal of Internal Medicine, Volume: 3 Issue: Supplement 1 Special Issue. https://doi.org/10.46310/tjim.876204

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References (10)

Srinivasan S, Slomovic AR. Sjögren syndrome. Compr Ophthalmol Update. 2007 Jul-Aug;8(4):205-12. PMID: 17999834.
Jonsson R, Vogelsang P, Volchenkov R, Espinosa A, Wahren-Herlenius M, Appel S. The complexity of Sjögren's syndrome: novel aspects on pathogenesis. Immunol Lett. 2011 Dec 30;141(1):1-9. doi: 10.1016/j.imlet.2011.06.007. Epub 2011 Jul 12. PMID: 21777618.
Yang HX, Wang J, Wen YB, et al. Renal involvement in primary Sjögren’s syndrome: a retroprospective study of 103 biopsy-proven cases from a single center in China. Int J Reumat Dis. 2017;21:222-8.
Kidder D, Rutherford E, Kipgen D, Fleming S, Geddes C, Stewart GA. Kidney biopsy findings in primary Sjögren syndrome. Nephrol Dial Transplant. 2015;30:1363-9.
D’Agati V. D., Fogo A. B., Bruijn J. A., Jennette J. C. Pathologic classification of focal segmental glomerulosclerosis: a working proposal. American Journal of Kidney Diseases. 2004;43(2):368–382. doi: 10.1053/j.ajkd.2003.10.024.
A. V. Goules, I. P. Tatouli, H. M. Moutsopoulos, and A. G. Tzioufas, “Clinically significant renal involvement in primary Sjögren’s syndrome: clinical presentation and outcome,” Arthritis & Rheumatism, vol. 65, no. 11, pp. 2945–2953, 2013.
S. Maripuri, J. P. Grande, T. G. Osborn et al., “Renal involvement in primary Sjögren’s syndrome: a clinicopathologic study,” Clinical Journal of the American Society of Nephrology, vol. 4, no. 9, pp. 1423–1431, 2009.
Shigekazu Kurihara, Makoto Harada, Tohru Ichikawa, Takashi Ehara, Mamoru Kobayashi, "Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Complicating Sjögren’s Syndrome: A Case Report and Literature Review", Case Reports in Rheumatology, vol. 2019, Article ID 1749795, 6 pages, 2019.
Ren H., Wang W. M., Chen X. N., et al. Renal involvement and followup of 130 patients with primary Sjögren’s syndrome. Journal of Rheumatology. 2008;35(2):278–284.
Jasiek M., Karras A., Le Guern V., et al. A multicentre study of 95 biopsy-proven cases of renal disease in primary Sjögren’s syndrome. Rheumatology. 2017;56(3):362–370