In this report, a case of severe AP triggered by HTG with other metabolic syndrome components like type 2 diabetes mellitus and obesity is presented.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:ABSTRACT: Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP).
📊
Key Findings & Data:The primary treatment goal in severe HTG is to restore triglyceride levels within normal ranges which can be achieved with lipid lowering drugs mainly fenofibrates, fluid replacement, intravenous insulin infusion and/ or plasmapheresis treatments.
💡
Conclusion & Impact:In this report, a case of severe AP triggered by HTG with other metabolic syndrome components like type 2 diabetes mellitus and obesity is presented.
ABSTRACT: Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP). It is caused by disorders in lipoprotein metabolism due to primary or secondary causes. Metabolic syndrome is also an important factor contributing to the development of HTG. The primary treatment goal in severe HTG is to restore triglyceride levels within normal ranges which can be achieved with lipid lowering drugs mainly fenofibrates, fluid replacement, intravenous insulin infusion and/ or plasmapheresis treatments. Strict diet restricted from fat and simple sugars, exercise and weight control also contribute to HTG control in long term follow up. In this report, a case of severe AP triggered by HTG with other metabolic syndrome components like type 2 diabetes mellitus and obesity is presented.
Fortson MR, Freedman SN, Webster PD 3rd. Clinical assessment of hyperlipidemic pancreatitis. Am J Gastroenterol 1995; 90:2134.
Tenner S, Baillie J, DeWitt J, Vege SS. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol 2013;108:1400-15.
Zhang W, et al. Hypertriglyceridemia aggravates ER stress and pathogenesis of acute pancreatitis. Hepatogastroenterology 2012;59:2318-26
Gelrud A, Whitcomb DC. Hypertriglyceridemia-induced acute pancreatitis. Uptodate, 2021.