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Journals / Turkish Journal of Internal Medicine / 2026 / Volume: 3 Issue: Supplement 1 Special Issue

A case report of euglycemic ketoacidosis due to dapagliflozin treatment

Murat Çalapkulu(ANKARA DIŞKAPI YILDIRIM BEYAZIT SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-7445-2275
Muhammed Erkam Sencar(ANKARA DIŞKAPI YILDIRIM BEYAZIT SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-5581-4886
İlknur Öztürk Ünsal(ANKARA DIŞKAPI YILDIRIM BEYAZIT SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-3999-6426
Hayri Bostan(ANKARA DIŞKAPI YILDIRIM BEYAZIT SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-4957-9856
Erman Çakal(ANKARA DIŞKAPI YILDIRIM BEYAZIT SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-4455-7276
Pages
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Publication Date
2021-03-07
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the current report, we aimed to present a case of euglycemic DKA using dapagliflozin treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Diabetic ketoacidosis (DKA) is a leading cause of mortality and morbidity in type 2 diabetic patients.
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Key Findings & Data:Sodium-glucose co-transporter (SGLT-2) inhibitors are a new antidiabetic treatment class that increases the renal excretion of glucose.
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Conclusion & Impact:In the current report, we aimed to present a case of euglycemic DKA using dapagliflozin treatment.
🔬Design:Case Report
📍Scope:2015 Verileri
⚙️Variables:Dapagliflozin · sodium-glucose co-transporter 2 inhibitors · euglycemic ketoacidosis

Abstract

Diabetic ketoacidosis (DKA) is a leading cause of mortality and morbidity in type 2 diabetic patients. Sodium-glucose co-transporter (SGLT-2) inhibitors are a new antidiabetic treatment class that increases the renal excretion of glucose. The Food and Drug Administration issued a warning in May 2015 notifying that patients using this class of anti-diabetic drugs may develop DKA. Risk factors for DKA development among patients who take SGLT-2 inhibitors include carbohydrate intake/starvation or acute illness. In the current report, we aimed to present a case of euglycemic DKA using dapagliflozin treatment.

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Cite This Article

Çalapkulu, M., Sencar, M. E., Ünsal, İ. Ö., Bostan, H., Çakal, E. (2021). A case report of euglycemic ketoacidosis due to dapagliflozin treatment. Turkish Journal of Internal Medicine, Volume: 3 Issue: Supplement 1 Special Issue. https://doi.org/10.46310/tjim.877156

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References (8)

  1. Chao EC, Henry RR. SGLT2 inhibition--a novel strategy for diabetes treatment. Nat Rev Drug Discov 2010;9(7):551–9.
  2. Dhatariya KK, Umpierrez GE. Guidelines for management of diabetic ketoacidosis: time to revise? Lancet Diabetes Endocrinol 2017;5(5):321–3.
  3. Yu X, Zhang S, Zhang L. Newer Perspectives of Mechanisms for Euglycemic Diabetic Ketoacidosis. Int J Endocrinol 2018;2018:7074868.
  4. Fralick M, Schneeweiss S, Patorno E. Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor. N Engl J Med 2017;376(23):2300–2.
  5. Food and Drug Administration, FDA drug safety communication: FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the bloodNovember 2019 http://www.fda.gov/Drugs/Drug.Safety/ucm446845.htm.
  6. Taylor SI, Blau JE, Rother KI. SGLT2 Inhibitors May Predispose to Ketoacidosis. J Clin Endocrinol Metab 2015;100(8):2849–52.
  7. American Diabetes Association. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2021. Diabetes Care 2021;44(Suppl 1):S111–24.
  8. Burke KR, Schumacher CA, Harpe SE. SGLT2 Inhibitors: A Systematic Review of Diabetic Ketoacidosis and Related Risk Factors in the Primary Literature. Pharmacotherapy 2017;37(2):187–94.