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Journals / Turkish Journal of Internal Medicine / 2026 / Volume: 3 Issue: 2

Markedly elevated lipase as the first manifestation of celiac disease: Case Report

Ahmet Bilgehan Şahin(Uludag University, Faculty of Medicine, Department of Medical Oncology)0000-0002-7846-0870
Fazıl Hunutlu(Uludag University, Faculty of Medicine, Department of Medical Oncology)0000-0002-4991-9830
Nesrin Uğraş(Bursa Uludag University, Faculty of Medicine, Department of Pathology)0000-0003-0127-548X
Macit Gülten(Bursa Uludag University, Faculty of Medicine, Department of Gastroenterology)0000-0002-4186-0731
Pages
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Publication Date
2021-04-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Herein, we report a patient with newly diagnosed CD, representing markedly elevated serum lipase level with normal amylase.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Lipase is a hydrolytic enzyme and commonly used for the diagnosis of pancreatitis with amylase.
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Key Findings & Data:Except for pancreatitis, lipase is elevated in many clinical conditions such as hepatobiliary disorders, bowel diseases, malignancies, renal impairment.
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Conclusion & Impact:Herein, we report a patient with newly diagnosed CD, representing markedly elevated serum lipase level with normal amylase.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:celiac disease · hyperlipasemia · macrolipasemia

Abstract

Lipase is a hydrolytic enzyme and commonly used for the diagnosis of pancreatitis with amylase. Except for pancreatitis, lipase is elevated in many clinical conditions such as hepatobiliary disorders, bowel diseases, malignancies, renal impairment. Celiac disease (CD) should be considered as one of the causes. In patients with CD, the frequency of pancreatic hyperenzymemia and possible pathophysiological mechanisms are not well studied. To date, several mechanisms explaining pancreatic hyperenzymemia in CD are reported. Malnutrition, disease bowel induced pancreatic dysfunction, autoimmune pancreatic inflammation, and macroenzymemia are the main ones. Herein, we report a patient with newly diagnosed CD, representing markedly elevated serum lipase level with normal amylase.

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Cite This Article

Şahin, A. B., Hunutlu, F., Uğraş, N., Gülten, M. (2021). Markedly elevated lipase as the first manifestation of celiac disease: Case Report. Turkish Journal of Internal Medicine, Volume: 3 Issue: 2. https://doi.org/10.46310/tjim.814732

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