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Journals / Turkish Journal of Analytical Chemistry / 2022 / Cilt: 4 Sayı: 2

A Simple and High Throughput Methodology for Simultaneous Determination of Levodopa and Carbidopa

İrem Kırlangıç(EGE UNIVERSITY)0000-0001-8506-1491
Kemal Volkan Özdokur(ERZİNCAN BİNALİ YILDIRIM ÜNİVERSİTESİ)0000-0002-9540-7203
Fatma Nil Ertas(EGE UNIVERSITY)0000-0001-8982-9621
Pages
52–58
Publication Date
2022-12-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The sensitivity of the method was found comparable to other methods depending on the sophisticated electrode modifications and the limits of detection were calculated as sub micromolar levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Parkinson's disease (PD) is a degenerative disorder of the central nervous system.
📊
Key Findings & Data:The motor symptoms of PD disease result from the death of dopamine-generating cells in a region of the mid brain and the dopamine precursor levodopa (L-Dopa) is used for the treatment.
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Conclusion & Impact:The sensitivity of the method was found comparable to other methods depending on the sophisticated electrode modifications and the limits of detection were calculated as sub micromolar levels.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:L-Dopa · Carbidopa · pencil graphite electrode

Abstract

Parkinson's disease (PD) is a degenerative disorder of the central nervous system. The motor symptoms of PD disease result from the death of dopamine-generating cells in a region of the mid brain and the dopamine precursor levodopa (L-Dopa) is used for the treatment. Carbidopa (Car) is administered in association with L-Dopa in pharmaceutical formulation as an inhibitor on the decarboxylase activity. Thus, their simultaneous determination is of great importance because of their co-existence in pharmaceutical preparations. Present study deals with a simple method development for simultaneous voltammetric determination of L-Dopa and Car at a pencil graphite electrode (PGE) via monitoring the reduction peak of L-Dopa and the second oxidation peak of Car. The sensitivity of the method was found comparable to other methods depending on the sophisticated electrode modifications and the limits of detection were calculated as sub micromolar levels.

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Cite This Article

Kırlangıç, İ., Özdokur, K. V., Ertas, F. N. (2022). A Simple and High Throughput Methodology for Simultaneous Determination of Levodopa and Carbidopa. Turkish Journal of Analytical Chemistry, Cilt: 4 Sayı: 2, 52–58. https://doi.org/10.51435/turkjac.1119121

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