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Journals / Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi / 2026 / Cilt: 2 Sayı: 1

Microwave assisted synthesis of some new Schiff’s bases from 2,4-dihydro-3H-1,2,4-triazol-3-one

Bazı Schiff bazlarının 2,4-dihidro-3H-1,2,4-triazol-3-on'dan mikrodalga destekli sentezi

Emre Menteşe(Recep Tayyip Erdogan University)0000-0003-4105-8666
Fatih Yılmaz(RECEP TAYYİP ERDOĞAN ÜNİVERSİTESİ)0000-0002-6666-3566
Bahittin Kahveci(KARADENİZ TEKNİK ÜNİVERSİTESİ)0000-0001-7394-0552
Pages
1–5
Publication Date
2021-06-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The chemical structures of newly synthesized triazole containing schiff bases were identified using IR, 1HNMR, and mass spectroscopy data.

📌 3 Key Takeaways

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Objective & Hypothesis:In this manuscript, a new series of 1,2,4-triazole-3-ones containing imin function was synthesized from 5-(4-bromobenzyl)-4-amino-2H-1,2,4-triazol-3(4H)-one and aromatic aldehyde by using microwave irradiation technique via schiff base reaction.
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Key Findings & Data:Firstly, ethyl imido-p-bromophenylacetate hydrochloride (2) was synthesized according to the pinner method in the literature.
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Conclusion & Impact:The chemical structures of newly synthesized triazole containing schiff bases were identified using IR, 1HNMR, and mass spectroscopy data.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:triazol · Schiff bazı · mikrodalga sentez

Abstract

In this manuscript, a new series of 1,2,4-triazole-3-ones containing imin function was synthesized from 5-(4-bromobenzyl)-4-amino-2H-1,2,4-triazol-3(4H)-one and aromatic aldehyde by using microwave irradiation technique via schiff base reaction. Firstly, ethyl imido-p-bromophenylacetate hydrochloride (2) was synthesized according to the pinner method in the literature. Then, compound 2 was reacted with ethyl carbazate to synthesized ethyl p-bromophenylacetate etoxycarbonylhydrazone (3) compound. Then, 5-(4-bromobenzyl)-4- amino-2H-1,2,4-triazol-3(4H)-one (4) was synthesized from the reaction of ethyl p-bromophenylacetate etoxycarbonylhydrazone (3) with hydrazine monohydrate. Then, it was converted to their corresponding triazole containing Schiff bases (5a-e) with the reaction of corresponding aromatic aldehydes in ethanol by using the microwave irradiation method. This microwave technique has some advantages, including rapid and uniform heating, higher product yield and purity, mild reaction conditions, low energy requirement and shorter reaction time. The chemical structures of newly synthesized triazole containing schiff bases were identified using IR, 1HNMR, and mass spectroscopy data.

Özet

Bu çalışmada, imin grubu içeren yeni bir seri 1,2,4-triazol-3-on türevleri mikrodalga destekli sentezlenmiştir. 5- ( 4 -Bromobenzil) - 4 - amino- 2H - 1,2,4 - triazol - 3(4H) - on bileşiği ester etoksikarbonil hidrazonun hidrazin hidrat ile reaksiyonundan elde edilmiş ve daha sonra bu bileşik çeşitli aldehitler kullanılarak Schiff bazlarına dönüştürülmüştür. Yeni sentezlenen bileşiklerin yapı aydınlatılmasında IR, 1H-NMR ve kütle spektroskopisi kullanıldı. Bu çalışmada, imin grubu içeren yeni bir seri 1,2,4-triazol-3-on türevleri mikrodalga destekli sentezlenmiştir. 5- ( 4 -Bromobenzil) - 4 - amino- 2H - 1,2,4 - triazol - 3(4H) - on bileşiği ester etoksikarbonil hidrazonun hidrazin hidrat ile reaksiyonundan elde edilmiş ve daha sonra bu bileşik çeşitli aldehitler kullanılarak Schiff bazlarına dönüştürülmüştür. Yeni sentezlenen bileşiklerin yapı aydınlatılmasında IR, 1H-NMR ve kütle spektroskopisi kullanıldı.

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Cite This Article

Menteşe, E., Yılmaz, F., Kahveci, B. (2021). Microwave assisted synthesis of some new Schiff’s bases from 2,4-dihydro-3H-1,2,4-triazol-3-one. Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, Cilt: 2 Sayı: 1, 1–5. https://doi.org/10.53501/rteufemud.819653

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