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Journals / Medical Records / 2024 / Cilt: 6 Sayı: 3

Could ELABELA be a Protective Biomarker in Patients with Abnormal Uterine Bleeding?

Tuğba Raika Kıran(MALATYA TURGUT ÖZAL ÜNİVERSİTESİ)0000-0002-3724-0249
Umran Karabulut(ACIBADEM KAYSERİ HOSPİTAL)0000-0002-1935-3696
Önder Otlu(MALATYA TURGUT ÖZAL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI)0000-0001-5958-7609
Engin Yıldırım(MALATYA TURGUT ÖZAL ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, KADIN HASTALIKLARI VE DOĞUM ANABİLİM DALI)0000-0001-7937-4141
Mehmet Erdem(MALATYA TURGUT ÖZAL ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOKİMYA ANABİLİM DALI)0000-0002-9100-2479
Feyza İnceoğlu(MALATYA TURGUT OZAL UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOSTATISTICS)0000-0003-1453-0937
Pages
413–418
Publication Date
2024-09-24
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results show that ELA is a good predictor of the pathophysiological process of AUB.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Abnormal uterine bleeding (AUB) is a health problem characterized by various symptoms such as heavy and prolonged menstrual bleeding, affecting approximately 30% of female patients both physiologically and psychologically.
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Key Findings & Data:The objective of this study was to assess serum Elabela (ELA) concentrations in women aged 18 and above diagnosed with functional AUB, and to compare these concentrations with those of healthy women.
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Conclusion & Impact:These results show that ELA is a good predictor of the pathophysiological process of AUB.
🔬Design:Klinik Araştırma
📍Scope:2022 Verileri
⚙️Variables:Elabela · abnormal uterine bleeding · PALM-COEIN

Abstract

Aim: Abnormal uterine bleeding (AUB) is a health problem characterized by various symptoms such as heavy and prolonged menstrual bleeding, affecting approximately 30% of female patients both physiologically and psychologically. The objective of this study was to assess serum Elabela (ELA) concentrations in women aged 18 and above diagnosed with functional AUB, and to compare these concentrations with those of healthy women. Material and Method: This prospective case-control study was performed from August 18, 2022 to December 30, 2022. This was a cross-sectional study including 50 women who applied to the gynecology service of Malatya Turgut Özal Training and Research Hospital with complaints of AUB and 50 women without AUB who underwent gynecological examination. The presence of AUB in patients was determined based on clinical examination conducted by a gynecologist and medical records. Demographic and clinical characteristics were recorded. Serum ELA levels were determined by commercial ELISA kit. Results: Serum ELA levels was significantly lower in patients with AUB (581.54±272.25 pg/mL) compared to the healthy group (744.55±300.31 pg/mL, p=0.005). In this study, ELA in patients with AUB showed 98% sensitivity and 80% specificity with a cut off value of 411.41 pg/mL (area under the curve [AUC], 68.1%; p=0.002). Conclusion: Serum ELA levels in patients with AUB were significantly lower than in healthy women. These results show that ELA is a good predictor of the pathophysiological process of AUB.

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Cite This Article

Kıran, T. R., Karabulut, U., Otlu, Ö., Yıldırım, E., Erdem, M., İnceoğlu, F. (2024). Could ELABELA be a Protective Biomarker in Patients with Abnormal Uterine Bleeding?. Medical Records, Cilt: 6 Sayı: 3, 413–418. https://doi.org/10.37990/medr.1490041

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