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Journals / Journal of Medical Topics and Updates / 2026 / Cilt: 1 Sayı: 1

Can the systemic immune-inflammatory index be a new indicator for the diagnosis and follow-up of alzheimer's disease?

Sistemik immun-inflamatuar indeks alzheimer hastalığının tanısı ve takibi için yeni bir gösterge olabilir mi?

Aslı Bolayır(CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6566-3751
Tuğba Raika Kıran(MALATYA TURGUT OZAL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-3724-0249
Aysun Bay Karabulut(MALATYA TURGUT OZAL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-7873-2805
Pages
1–13
Publication Date
2022-04-29
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, the relationship of this inflammatory process with the severity and duration of the disease and drug use is still unknown.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease whose prevalence continues to increase in the elderly population.
📊
Key Findings & Data:It has been shown that the neutrophil/lymphocyte ratio (NLR), is increased in AD compared to the normal population.
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Conclusion & Impact:However, the relationship of this inflammatory process with the severity and duration of the disease and drug use is still unknown.
🔬Design:Klinik Araştırma
📍Scope:Comprehensive Sample
⚙️Variables:Nötrofil/Lenfosit Oranı · Sistemik İmmün-İnflamatuar İndeks · İnflamasyon

Abstract

Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease whose prevalence continues to increase in the elderly population. It has been shown that the neutrophil/lymphocyte ratio (NLR), is increased in AD compared to the normal population. However, there is no study in the literature regarding the role of systemic immune-inflammatory index (SII), which is calculated according to the formula of peripheral platelet count X neutrophil count/lymphocyte count, in AD. Therefore, our aim in this study was to reveal the role of SII in the diagnosis and follow-up of AD and to determine the relationship of this value with severity, duration of disease and drug use by comparing it with NLR. Materials and Methods: Our retrospective study consisted of 94 gender and age matched healthy volunteers and 102 patients who applied to our clinic were diagnosed with AD. Results: There was no difference between the patient and control groups in terms of age, gender, platelet and neutrophil counts, and SII values. While lymphocyte count was lower in-patient group; NLR and CRP detected higher (p=0.001, p=0.001, p=0.001, respectively). While SII increased as both disease duration and severity elevated; no statistically significant correlation was found between NLR and the severity and duration of the disease and drug use. Conclusions: Based on the data of our study, we can suggest that inflammatory process increases in AD. However, the relationship of this inflammatory process with the severity and duration of the disease and drug use is still unknown.

Özet

Amaç: Tanısı ve takibinde kullanılan ideal bir biyobelirteç olmayan Alzheimer hastalığı (AH), prevalansı ileri yaş popülasyonunda artmaya devam eden kronik bir nörodejeneratif hastalıktır. Nötrofil /lenfosit oranın (NLR) AH’da normal popülasyona göre artmış olduğu gösterilmiştir. Ancak periferik platelet sayısı X nötrofil sayısı/ lenfosit sayısı formülüne göre hesaplanan sistemik immun-inflamatuar indeks (SII)’in AH’ndaki yeri ile ilgili literatürde henüz bir çalışma bulunmamaktadır. Bu nedenle bu çalışmadaki amacımız AH’nın teşhis ve takibinde NLR ile kıyaslayarak SII’nin yerini ortaya koymak ve bu değerin hastalığın ciddiyeti, süresi ve ilaç kullanımı ile ilişkisini tespit etmektir.

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Cite This Article

Bolayır, A., Kıran, T. R., Karabulut, A. B. (2022). Can the systemic immune-inflammatory index be a new indicator for the diagnosis and follow-up of alzheimer's disease?. Journal of Medical Topics and Updates, Cilt: 1 Sayı: 1, 1–13. https://ajindex.com/articles/1618914

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