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Journals / Kommagene Biyoloji Dergisi / 2026 / Cilt: 10 Sayı: 1

Linking Phenolic Composition with Biological Activities in Three Endemic Marrubium Taxa

Üç Endemik Marrubium Taksonunda Fenolik Bileşimin Biyolojik Aktiviteler ile İlişkilendirilmesi

Muhsine Kevser Gürtürk Gözcü(DİCLE ÜNİVERSİTESİ)0009-0009-5435-0966
Ömerül Faruk Tavlı(BİRUNİ ÜNİVERSİTESİ)0000-0002-3617-020X
Alevcan Kaplan(DİCLE ÜNİVERSİTESİ)0000-0001-6738-7527
Ercan Çınar(BATMAN UNIVERSITY)0000-0003-0419-7798
Serpil Demirci Kayıran(CUKUROVA UNIVERSITY)0000-0001-8340-3347
Hasan Şahin(DICLE UNIVERSITY)0000-0002-8325-8116
Mehmet Boğa(DICLE UNIVERSITY)0000-0003-4163-9962
Esra Eroğlu Özkan(İstanbul Üniversitesi)0000-0002-1569-2535
Pages
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Publication Date
2026-05-22
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, the findings indicate that variations in phenolic composition may be associated with differences in biological activities among the investigated taxa.

📌 3 Key Takeaways

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Objective & Hypothesis:This study investigates the relationship between phenolic composition and biological activities of three endemic Marrubium taxa, namely Marrubium parviflorum subsp. oligodon (Boiss.) Seybold, Marrubium cephalanthum Boiss. & Noë, and Marrubium globosum Montbret & Aucher ex Benth.
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Key Findings & Data:This taxon also showed the strongest antioxidant activity in DPPH (IC₅₀ = 26.28 μg/mL) and CUPRAC (A₀.₅ = 29.82 μg/mL) assays.
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Conclusion & Impact:Overall, the findings indicate that variations in phenolic composition may be associated with differences in biological activities among the investigated taxa.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Marrubium · fenolik bileşik · antioksidan aktivite

Abstract

This study investigates the relationship between phenolic composition and biological activities of three endemic Marrubium taxa, namely Marrubium parviflorum subsp. oligodon (Boiss.) Seybold, Marrubium cephalanthum Boiss. & Noë, and Marrubium globosum Montbret & Aucher ex Benth. Ethanolic extracts prepared from the aerial parts were analyzed by HPLC-UV and twelve phenolic compounds were quantitatively identified. Among the investigated taxa, M. cephalanthum exhibited the highest phenolic content with verbascoside, rutin, and hyperoside as the predominant constituents. This taxon also showed the strongest antioxidant activity in DPPH (IC₅₀ = 26.28 μg/mL) and CUPRAC (A₀.₅ = 29.82 μg/mL) assays. In contrast, M. globosum demonstrated the highest activity in the ABTS assay (IC₅₀ = 3.58 μg/mL) and showed relatively higher cholinesterase inhibitory activity (AChE: A₀.₅ = 65.14 μg/mL; BChE: A₀.₅ = 132.73 μg/mL). Regarding lipoxygenase inhibition, M. parviflorum subsp. oligodon exhibited the strongest effect (IC₅₀ = 106.55 μg/mL), followed by M. cephalanthum and M. globosum. No considerable inhibitory activity was observed against α-glucosidase or α-amylase under the tested conditions. Overall, the findings indicate that variations in phenolic composition may be associated with differences in biological activities among the investigated taxa. These results contribute to the understanding of the phytochemical–bioactivity relationship in Marrubium species and provide a basis for further bioactivity-guided studies.

Özet

Bu çalışmada, Marrubium parviflorum subsp. oligodon (Boiss.) Seybold, Marrubium cephalanthum Boiss. & Noë ve Marrubium globosum Montbret & Aucher ex Benth. olmak üzere Türkiye’ye endemik üç Marrubium taksonunun fenolik bileşimi ile biyolojik aktiviteleri arasındaki ilişki araştırılmıştır. Bitkilerin toprak üstü kısımlarından elde edilen etanol ekstreleri HPLC-UV yöntemi ile analiz edilmiş ve toplamda 12 fenolik bileşik kantitatif olarak belirlenmiştir. İncelenen taksonlar arasında M. cephalanthum’un en yüksek fenolik içeriğe sahip olduğu ve başlıca bileşenlerinin verbaskozid, rutin ve hiperozid olduğu saptanmıştır. Bu takson ayrıca DPPH (IC₅₀ = 26.28 μg/mL) ve CUPRAC (A₀.₅ = 29.82 μg/mL) analizlerinde en yüksek antioksidan aktiviteyi göstermiştir. Buna karşılık, M. globosum ABTS analizinde en yüksek aktiviteyi (IC₅₀ = 3.58 μg/mL) sergilemiş ve kolinesteraz inhibisyonu açısından diğer taksonlara göre daha yüksek aktivite göstermiştir (AChE: A₀.₅ = 65.14 μg/mL; BChE: A₀.₅ = 132.73 μg/mL). Lipoksijenaz inhibisyonu bakımından en güçlü etki M. parviflorum subsp. oligodon’da gözlenmiş (IC₅₀ = 106.55 μg/mL), bunu M. cephalanthum ve M. globosum izlemiştir. Buna karşılık, uygulanan koşullar altında hiçbir taksonda α-glukozidaz ve α-amilaz enzimlerine karşı anlamlı bir inhibisyon gözlenmemiştir. Elde edilen bulgular, fenolik bileşimdeki farklılıkların biyolojik aktivitelerdeki değişimlerle ilişkili olabileceğini göstermektedir. Bu sonuçlar, Marrubium türlerinde fitokimyasal bileşim ile biyolojik aktivite arasındaki ilişkinin anlaşılmasına katkı sağlamakta olup, ileri düzey çalışmalar için temel oluşturmaktadır.

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Cite This Article

Gözcü, M. K. G., Tavlı, Ö. F., Kaplan, A., Çınar, E., Kayıran, S. D., Şahin, H., Boğa, M., Özkan, E. E. (2026). Linking Phenolic Composition with Biological Activities in Three Endemic Marrubium Taxa. Kommagene Biyoloji Dergisi, Cilt: 10 Sayı: 1. https://doi.org/10.31594/commagene.1917462

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