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Journals / Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi / 2026 / Cilt: 8 Sayı: 3

Evaluation of the Relationship between Depression and the Volume of Olfactory Regions by Parcellation Method

Depresyon ve Koku Bölgeleri Hacmi Arasındaki İlişkinin Parselasyon Yöntemiyle Değerlendirilmesi

Merve Yurt(BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0005-8177-4474
Merve Şahin Can(BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-4985-5689
Emrah Özcan(BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6373-4744
Aslıhan Çetinel(BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ)0009-0002-2767-9175
Esma Gül(BALIKESİR ÜNİVERSİTESİ, İVRİNDİ SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU)0000-0001-6234-937X
Ömür Karaca(BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8218-8881
İlter Kuş(BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-3194-267X
Pages
236–243
Publication Date
2026-09-09
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The data obtained in light of these findings will contribute to understanding the cause-and-effect relationship between depression and loss of smell; for clinicians, it is expected to serve as a guide in diagnosis and treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Scientific studies in the literature have demonstrated olfactory loss and reduced olfactory bulb volume in individuals with major depressive disorder.
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Key Findings & Data:In the study, Magnetic Resonance İmaging (MRI) images of 33 patients with major depressive disorder and 33 healthy controls from Balıkesir University Hospital's Mental Health Clinic were retrospectively analyzed.
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Conclusion & Impact:The data obtained in light of these findings will contribute to understanding the cause-and-effect relationship between depression and loss of smell; for clinicians, it is expected to serve as a guide in diagnosis and treatment.
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Major depresyon · koku · MRG

Abstract

Scientific studies in the literature have demonstrated olfactory loss and reduced olfactory bulb volume in individuals with major depressive disorder. This study aims to evaluate the correlation between major depressive disorder and olfactory region volume. In the study, Magnetic Resonance İmaging (MRI) images of 33 patients with major depressive disorder and 33 healthy controls from Balıkesir University Hospital's Mental Health Clinic were retrospectively analyzed. In the obtained MRI series, the volumes of the amygdala, fusiform gyrus, anterior commissure, olfactory radiation, and entorhinal area, which are involved in olfaction, were measured using a parcellation method. All data were transferred to SPSS and analyzed quantitatively. The statistical analysis of the variables examined in the study revealed that the right and left amygdalae tend to be smaller in individuals with illness. It was determined that there was a positive correlation among the parameters evaluated in the study: left amygdala, left entorhinal area, right and left fusiform gyrus volumes, and the Hamilton Depression Scale. As a result of the research, it was revealed in the direction of morphometric analysis that there is a negative relationship between major depressive disorder and olfactory regions. The data obtained in light of these findings will contribute to understanding the cause-and-effect relationship between depression and loss of smell; for clinicians, it is expected to serve as a guide in diagnosis and treatment.

Özet

Major depresif bozukluğu bulunan bireylerde koku kaybının görüldüğü ve bulbus olfactorius hacminde küçülme meydana geldiği, literatürde yer alan bilimsel araştırmalarla ortaya konmuştur. Bu çalışmada, majör depresif bozukluk ile koku bölgelerinin hacmi arasındaki korelasyonun değerlendirilmesi amaçlanmaktadır. Çalışmada, Balıkesir Üniversitesi Eğitim ve Araştırma Hastanesi Ruh Sağlığı ve Hastalıkları Polikliniği'nde majör depresif bozukluk tanısı konulan 33 hasta ve kontrol grubunu oluşturacak 33 sağlıklı bireyin Manyetik Rezonans Görüntüleme (MRG) görüntüleri retrospektif olarak incelendi. Elde edilen MRG serilerinde koku duyusunda rol alan amygdala, gyrus fusiformis, commissura anterior, radiatio olfactoria ve entorhinal alan hacmi parselasyon yöntemi kullanılarak ölçüldü. Tüm veriler SPSS yazılımına aktarılarak kantitatif olarak analiz edildi. Araştırmada incelenen değişkenlerin istatistiksel analiz sonuçlarına göre, sağ-sol amigdalaların hasta bireylerde daha küçük hacme sahip olma eğilimi gösterdiği tespit edildi. Çalışmada değerlendirilen parametrelerden, sol amigdala, sol entorhinal alan ve sağ-sol fusiform gyrus hacimleri ile Hamilton Depresyon Ölçeği skalası arasında pozitif bir korelasyon olduğu görüldü. Yapılan araştırmalar neticesinde, majör depresif bozukluk ile koku bölgeleri arasında negatif bir ilişki bulunduğu morfometrik analizler doğrultusunda ortaya konmuştur. Bu veriler ışığında elde edilen verilerin depresyon ve koku kaybı arasındaki neden-sonuç ilişkisinin anlaşılmasına katkıda bulunacağı, klinisyenler açısından ise tanı ve tedavide yol gösterici nitelikte olabileceği düşünülmektedir.

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Cite This Article

Yurt, M., Can, M. Ş., Özcan, E., Çetinel, A., Gül, E., Karaca, Ö., Kuş, İ. (2026). Evaluation of the Relationship between Depression and the Volume of Olfactory Regions by Parcellation Method. Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi, Cilt: 8 Sayı: 3, 236–243. https://doi.org/10.35365/ctjpp.26.3.01

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References (47)

  1. Abdelmotaleb, M. A. M., Fadeel, N. A., Abdel Naem, M. M., & Said, H. M. (2020). Sociodemographic and clinical characteristics of a sample of patients with major depressive disorder. Minia Journal of Medical Research, 31(2), 8–11. https://doi.org/10.21608/mjmr.2022.220825
  2. Ahmed, H. U., Hossain, M. D., Aftab, A., Soron, T. R., Alam, M. T., Chowdhury, M. W., & Uddin, A. (2017). Suicide and depression in the World Health Organization South-East Asia region: A systematic review. WHO South-East Asia Journal of Public Health, 6(1), 60–66. https://doi.org/10.4103/2224-3151.206167
  3. Al Aïn, S., Poupon, D., Hétu, S., Mercier, N., Steffener, J., & Frasnelli, J. (2019). Smell training improves olfactory function and alters brain structure. Neuroimage, 189, 45–54. https://doi.org/10.1016/j.neuroimage.2019.01.008
  4. Arıncı, K., & Elhan, A. (2014). Anatomi: duyu organları. Güneş Kitabevi, Ankara, Türkiye. ISBN: 978-975-277-514-5 Athanassi, A., Dorado Doncel, R., Bath, K. G., & Mandairon, N. (2021). Relationship between depression and olfactory sensory function: a review. Chem Senses, 46. https://doi.org/10.1093/chemse/bjab044
  5. Barresi, M., Ciurleo, R., Giacoppo, S., Foti Cuzzola, V., Celi, D., Bramanti, P., & Marino, S. (2012). Evaluation of olfactory dysfunction in neurodegenerative diseases. J Neurol Sci, 323(1-2), 16–24. https://doi.org/10.1016/j.jns.2012.08.028
  6. Besteher, B., Squarcina, L., Spalthoff, R., Bellani, M., Gaser, C., Brambilla, P., & Nenadić, I. (2019). Hippocampal volume as a putative marker of resilience or compensation to minor depressive symptoms in a nonclinical sample. Frontiers in Psychiatry, 10, 467. https://doi.org/10.3389/fpsyt.2019.00467
  7. Boku, S., Nakagawa, S., Toda, H., & Hishimoto, A. (2018). Neural basis of major depressive disorder: Beyond monoamine hypothesis. Psychiatry and clinical neurosciences, 72(1), 3–12. https://doi.org/10.1111/pcn.12604
  8. Brown, S. S., Rutland, J. W., Verma, G., Feldman, R., Alper, J., Schneider, M., Delman, B. N., Murrough, J., & Balchandani, P. (2019). Structural MRI at 7T reveals amygdala nuclei and hippocampal subfield volumetric association with major depressive disorder symptom severity. Scientific reports, 9(1), 10166. https://doi.org/10.1038/s41598-019-46687-7
  9. Cattarinussi, G., Delvecchio, G., Maggioni, E., Bressi, C., & Brambilla, P. (2021). Ultra-high field imaging in major depressive disorder: a review of structural and functional studies. Journal of Affective Disorders, 290, 65–73. https://doi.org/10.1016/j.jad.2021.04.056
  10. Croy, I., Yarina, S., & Hummel, T. (2013). Enhanced parosmia and phantosmia in patients with severe depression. Psychol Med, 43(11), 2460–2464. https://doi.org/10.1017/s0033291713001773
  11. Dündar, M. A., İlhan, M. N., & Karamüftüoğlu, N. (2020). The Prevalence And Possıble Rısk Factors Of Depressıon And Anxıety Dısorders In Syrıan Mıgrant Women In Turkey. Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi, 2(1), 14–19. https://doi.org/https://doi.org/10.35365/ctjpp.20.2.2
  12. Erzurumlu, R., Şengül, G., & Ulupınar, E. (2019). Nöroanatomi. Ankara, Türkiye. ISBN:978-975-277-747-7
  13. Faria, A. V., Hoon, A., Stashinko, E., Li, X., Jiang, H., Mashayekh, A., Akhter, K., Hsu, J., Oishi, K., & Zhang, J. (2011). Quantitative analysis of brain pathology based on MRI and brain atlases—applications for cerebral palsy. Neuroimage, 54(3), 1854-1861. https://doi.org/10.1016/j.neuroimage.2010.09.061
  14. Fujita, S., Mori, S., Onda, K., Hanaoka, S., Nomura, Y., Nakao, T., Yoshikawa, T., Takao, H., Hayashi, N., & Abe, O. (2023). Characterization of brain volume changes in aging individuals with normal cognition using serial magnetic resonance imaging. JAMA Network Open, 6(6), e2318153-e2318153. doi: https://doi.org/10.1001/jamanetworkopen.2023.18153
  15. Gray, J. P., Müller, V. I., Eickhoff, S. B., & Fox, P. T. (2020). Multimodal Abnormalities of Brain Structure and Function in Major Depressive Disorder: A Meta-Analysis of Neuroimaging Studies. The American Journal of Psychiatry, 177(5), 422–434. https://doi.org/10.1176/appi.ajp.2019.19050560
  16. Hamilton, J. P., Siemer, M., & Gotlib, I. H. (2008). Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Molecular Psychiatry, 13(11), 993–1000. http://dx.doi.org/10.1038/mp.2008.57
  17. Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry, 23(1), 56. https://doi.org/10.1136/jnnp.23.1.56
  18. Herrmann, T., Koeppel, C., Linn, J., Croy, I., & Hummel, T. (2023). Olfactory brain activations in patients with major depressive disorder. Scientific reports, 13(1), 10072. https://doi.org/10.1038/s41598-023-36783-0
  19. Höflich, A., Baldinger, P., Savli, M., Lanzenberger, R., & Kasper, S. (2012). Imaging treatment effects in depression. Reviews in the Neurosciences, 23(3), 227–252. https://doi.org/10.1515/revneuro-2012-0038
  20. Johnson, K. A., Fox, N. C., Sperling, R. A., & Klunk, W. E. (2012). Brain imaging in Alzheimer's disease. Cold Spring Harbor Perspectives in Medicine, 2(4), a006213. https://doi.org/10.1101/cshperspect.a006213
  21. Jung, S., Kim, J.-H., Kang, N.-O., Sung, G., Ko, Y.-G., Bang, M., Park, C. I., & Lee, S.-H. (2021). Fusiform gyrus volume reduction associated with impaired facial expressed emotion recognition and emotional intensity recognition in patients with schizophrenia spectrum psychosis. Psychiatry Research: Neuroimaging, 307, 111226. https://doi.org/10.1016/j.pscychresns.2020.111226
  22. Kelly, J. P., Wrynn, A. S., & Leonard, B. E. (1997). The olfactory bulbectomized rat as a model of depression: an update. Pharmacol Ther, 74(3), 299–316.https://doi.org/10.1016/s0163-7258(97)00004-1
  23. Kim, I. B., & Park, S.-C. (2021). The entorhinal cortex and adult neurogenesis in major depression. International Journal of Molecular Sciences, 22(21), 11725. https://doi.org/10.3390/ijms222111725
  24. Kocaman, H., Acer, N., Köseoğlu, E., Gültekin, M., & Dönmez, H. (2019). Evaluation of intracerebral ventricles volume of patients with Parkinson's disease using the atlas-based method: A methodological study. Journal of Chemical Neuroanatomy, 98, 124–130. https://doi.org/10.1016/j.jchemneu.2019.04.005
  25. Kohli, P., Soler, Z. M., Nguyen, S. A., Muus, J. S., & Schlosser, R. J. (2016). The association between olfaction and depression: a systematic review. Chemical Senses, 41(6), 479–486. https://doi.org/10.1093/chemse/bjw061 Li, A., Rao, X., Zhou, Y., & Restrepo, D. (2020). Complex neural representation of odor information in the olfactory bulb. Acta Physiol (Oxf), 228(1), e13333. https://doi.org/10.1111/apha.13333
  26. Lolk, A. (2013). Neurokognitive lidelser. In the Diagnostic and statistical manual of mental disorders. American Psychiatric Association. https://doi.org/10.1176/appi.books.9780890425596
  27. Lorenzetti, V., Allen, N. B., Fornito, A., & Yücel, M. (2009). Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies. Journal of Affective Disorders, 117(1-2), 1–17. https://doi.org/10.1016/j.jad.2008.11.021
  28. Monkul, E., Hatch, J. P., Nicoletti, M. A., Spence, S., Brambilla, P., Lacerda, A. d., Sassi, R. B., Mallinger, A., Keshavan, M., & Soares, J. C. (2007). Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Molecular Psychiatry, 12(4), 360–366. https://doi.org/10.1038/sj.mp.4001919
  29. Moorhead, T. W. J., McKirdy, J., Sussmann, J. E., Hall, J., Lawrie, S. M., Johnstone, E. C., & McIntosh, A. M. (2007). Progressive gray matter loss in patients with bipolar disorder. Biological Psychiatry, 62(8), 894–900. https://doi.org/10.1016/j.biopsych.2007.03.005
  30. Negoias, S., Croy, I., Gerber, J., Puschmann, S., Petrowski, K., Joraschky, P., & Hummel, T. (2010). Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression. Neuroscience, 169(1), 415–421. https://doi.org/10.1016/j.neuroscience.2010.05.012
  31. Pause, B. M., Miranda, A., Göder, R., Aldenhoff, J. B., & Ferstl, R. (2001). Reduced olfactory performance in patients with major depression. Journal of Psychiatric Research, 35(5), 271-277. https://doi.org/10.1016/S0022-3956(01)00029-2
  32. Ritchie, S. J., Cox, S. R., Shen, X., Lombardo, M. V., Reus, L. M., Alloza, C., Harris, M. A., Alderson, H. L., Hunter, S., & Neilson, E. (2018). Sex differences in the adult human brain: evidence from 5216 UK Biobank participants. Cerebral Cortex, 28(8), 2959–2975. https://doi.org/10.1093/cercor/bhy109
  33. Rochet, M., El-Hage, W., Richa, S., Kazour, F., & Atanasova, B. (2018). Depression, olfaction, and quality of life: a mutual relationship. Brain Sciences, 8(5), 80. https://doi.org/10.3390/brainsci8050080
  34. Rottstädt, F., Han, P., Weidner, K., Schellong, J., Wolff-Stephan, S., Strauß, T., Kitzler, H., Hummel, T., & Croy, I. (2018). Reduced olfactory bulb volume in depression: A structural moderator analysis. Hum Brain Mapp, 39(6), 2573–2582. https://doi.org/10.1002/hbm.24024
  35. Sağar, M. E., Kaya, F., Eroğlu, Y., Sinan, D., Çelik, Y., & Tosun, C. (2024). Examining the predictive role of depression on smartphone addiction. Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi, 6(2), 156–165. https://doi.org/https://doi.org/10.35365/ctjpp.24.2.06
  36. Schablitzky, S., & Pause, B. M. (2014). Sadness might isolate you in a non-smelling world: olfactory perception and depression. Frontiers in Psychology, 5, 45–45. https://doi.org/10.3389/fpsyg.2014.00045
  37. Shear, M. K., Vander Bilt, J., Rucci, P., Endicott, J., Lydiard, B., Otto, M. W., Pollack, M. H., Chandler, L., Williams, J., & Ali, A. (2001). Reliability and validity of a structured interview guide for the Hamilton Anxiety Rating Scale (SIGH‐A). Depression and Anxiety, 13(4), 166–178. https://doi.org/10.1002/da.1033
  38. Sivam, A., Wroblewski, K. E., Alkorta-Aranburu, G., Barnes, L. L., Wilson, R. S., Bennett, D. A., & Pinto, J. M. (2016). Olfactory dysfunction in older adults is associated with feelings of depression and loneliness. Chemical Senses, 41(4), 293–299. https://doi.org/10.1093/chemse/bjv088
  39. Soudry, Y., Lemogne, C., Malinvaud, D., Consoli, S.-M., & Bonfils, P. (2011). Olfactory system and emotion: common substrates. European Annals of Otorhinolaryngology, Head and Neck Diseases, 128(1), 18–23. https://doi.org/10.1016/j.anorl.2010.09.007
  40. Suhail, P., & Srinivasulu, Y. (2021). Perception of service quality, satisfaction, and behavioral intentions in Ayurveda healthcare. Journal of Ayurveda and Integrative Medicine, 12(1), 93–101. https://doi.org/10.1016/j.jaim.2020.10.011
  41. Taalman, H., Wallace, C., & Milev, R. (2017). Olfactory Functioning and Depression: A Systematic Review [Review]. 8. https://doi.org/10.3389/fpsyt.2017.00190
  42. Taner, D. (2019). Fonksiyonel Nöroanatomi (23. ed.). ODTÜ Yayıncılık, Ankara, Türkiye. ISBN 978-975-7064-05-3 Tannous, J., Godlewska, B. R., Tirumalaraju, V., Soares, J. C., Cowen, P. J., & Selvaraj, S. (2020). Stress, inflammation, and hippocampal subfields in depression: A 7 Tesla MRI Study. Translational Psychiatry, 10(1), 78. https://doi.org/10.1038/s41398-020-0759-0
  43. Van der Kolk, A. G., Hendrikse, J., Zwanenburg, J. J., Visser, F., & Luijten, P. R. (2013). Clinical applications of 7 T MRI in the brain. European Journal of Radiology, 82(5), 708–718. https://doi.org/10.1016/j.ejrad.2011.07.007
  44. Van Eijndhoven, P., van Wingen, G., van Oijen, K., Rijpkema, M., Goraj, B., Verkes, R. J., Oude Voshaar, R., Fernández, G., Buitelaar, J., & Tendolkar, I. (2009). Amygdala volume marks the acute state in the early course of depression. Biological Psychiatry, 65(9), 812–818. https://doi.org/10.1016/j.biopsych.2008.10.027
  45. Vythilingam, M., Vermetten, E., Anderson, G. M., Luckenbaugh, D., Anderson, E. R., Snow, J., Staib, L. H., Charney, D. S., & Bremner, J. D. (2004). Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry, 56(2), 101–112. https://doi.org/10.1016/j.biopsych.2004.04.002
  46. Weniger, G., Lange, C., & Irle, E. (2006). Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder. Journal of Affective Disorders, 94(1-3), 219–229. https://doi.org/10.1016/j.jad.2006.04.017
  47. Yao, Z., Fu, Y., Wu, J., Zhang, W., Yu, Y., Zhang, Z., Wu, X., Wang, Y., & Hu, B. (2020). Morphological changes in subregions of the hippocampus and amygdala in major depressive disorder patients. Brain Imaging and Behavior, 14(3), 653–667. https://doi.org/10.1007/s11682-018-0003-1