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Journals / Journal of Medicine and Palliative Care / 2026 / Volume: 4 Issue: 4

A noteworthy prognostic marker in extensive small cell lung cancer: lymphocyte/C-reactive protein ratio

Yaygın evre küçük hücreli akciğer kanserinde lenfosit/C-reaktif protein oranının prognostik önemi

Figen Öztürk Ergür(Ankara Atatürk Sanatoryum Eğitim ve araştırma Hastanesi)0000-0003-1915-714X
Ayperi Öztürk(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ATATÜRK GÖĞÜS HASTALIKLARI VE GÖĞÜS CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-0692-4784
Melahat Uzel Şener(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ATATÜRK GÖĞÜS HASTALIKLARI VE GÖĞÜS CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-8309-9517
Zeynep Tilbe Saymaz(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ATATÜRK GÖĞÜS HASTALIKLARI VE GÖĞÜS CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0003-3139-130X
Nihal Mutlu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ATATÜRK GÖĞÜS HASTALIKLARI VE GÖĞÜS CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)
Pages
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Publication Date
2023-08-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

A statistically significant difference exists between limited and extensive stages in terms of median overall survival (OS) (p<0.001).

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: We aimed to investigate the pre-treatment prognostic significance of lymphocyte/C-Reactive protein ratio (LCR), one of the inflammatory factors, in patients with extensive-stage small cell lung cancer (SCLC).
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Key Findings & Data:Methods: Medical records of 514 patients who were diagnosed with extensive-stage SCLC between 2010 and 2020 were examined retrospectively.
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Conclusion & Impact:A statistically significant difference exists between limited and extensive stages in terms of median overall survival (OS) (p<0.001).
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:small cell lung cancer · lymphocyte/CRP ratio · prognostic factor

Abstract

Aims: We aimed to investigate the pre-treatment prognostic significance of lymphocyte/C-Reactive protein ratio (LCR), one of the inflammatory factors, in patients with extensive-stage small cell lung cancer (SCLC). Methods: Medical records of 514 patients who were diagnosed with extensive-stage SCLC between 2010 and 2020 were examined retrospectively. LCR was calculated using the blood test results prior to chemotherapy. Results: The mean survival time for extensive-stage SCLC is 6 months (5.3-6.7). A statistically significant difference exists between limited and extensive stages in terms of median overall survival (OS) (p<0.001). The baseline LCR value of the patients was determined as 0.5 (0-311). LCR exerts a statistically significant effect on overall survival (0.025). Every 1 unit increase in LCR reduces death by 1.004 times. Conclusion: Pre-treatment LCR value can be used as an independent prognostic parameter associated with mean survival in extensive SCLC.

Özet

Amaç: Yaygın evre küçük hücreli akciğer kanseri (KHAK) hastalarında inflamatuar faktörlerden lenfosit/C-Reaktif protein oranının (LCR) tedavi öncesi prognostik önemini araştırmayı amaçladık. Araçlar ve Yöntem: Retrospektif olarak 2010-2020 tarihleri arasında KHAK tanısı almış ve yaygın evrede olan 514 hastanın tıbbi kayıtları incelendi. Kemoterapi öncesi alınan kan tetkiklerinden LCR hesaplandı. Bulgular: Yaygın evre KHAK’nin ortalama sağkalım süresi 6 aydır (5,3-6,7). Sınırlı ve yaygın hastalık arasında medyan genel sağkalım (OS) açısından istatistiksel anlamlı farklılık vardır (p<0.001). Hastaların başlangıç LCR değeri 0,5 (0-311) olarak saptandı. LCR’nin genel sağkalım üzerinde istatistiksel anlamlı etkisi vardır (0,025). LCR’deki 1 birimlik artış ölümü 1,004 kat azaltmaktadır Sonuç: Tedavi öncesi LCR, yaygın evre KHAK’de ortalama sağkalımı gösteren bağımsız bir prognostik parametre olarak kullanılabilir.

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Cite This Article

Ergür, F. Ö., Öztürk, A., Şener, M. U., Saymaz, Z. T., Mutlu, N. (2023). A noteworthy prognostic marker in extensive small cell lung cancer: lymphocyte/C-reactive protein ratio. Journal of Medicine and Palliative Care, Volume: 4 Issue: 4. https://doi.org/10.47582/jompac.1332258

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