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Journals / Journal of Medicine and Palliative Care / 2026 / Volume: 5 Issue: 1

Diagnostic performance of whole blood viscosity indices in predicting the presence and severity of coronary artery disease

Koronari arter hastalığının varlığını ve şiddetini tahmin etmede tam kan viskozite indekslerinin tanısal performansı

Ahmet Kıvrak(Ankara Etlik Şehir Hastanesi)0000-0001-5232-8436
Alp Yıldırım(Department of Cardiology, Kirsehir Training and Research Hospital, Kirsehir, Turkey)0000-0002-8517-2033
Pages
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Publication Date
2024-02-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In these patients, the MAPH score may serve as a potential screening tool and can be utilized for risk stratification.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: Growing evidence suggests that blood viscosity plays a crucial role in both the development and acceleration of atherosclerosis.
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Key Findings & Data:In this study, aimed to investigate the diagnostic performance of the mean platelet volume-age-total protein-hematocrit (MAPH) score, a new index for blood viscosity, in predicting the presence and severity of CAD in patients with suspected coronary artery disease (CAD).
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Conclusion & Impact:In these patients, the MAPH score may serve as a potential screening tool and can be utilized for risk stratification.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Blood viscosity · coronary artery disease · MAPH score

Abstract

Aims: Growing evidence suggests that blood viscosity plays a crucial role in both the development and acceleration of atherosclerosis. In this study, aimed to investigate the diagnostic performance of the mean platelet volume-age-total protein-hematocrit (MAPH) score, a new index for blood viscosity, in predicting the presence and severity of CAD in patients with suspected coronary artery disease (CAD). Methods: We retrospectively evaluated 431 patients who underwent coronary angiography. SYNTAX score (SS) were divided into 3 groups; low group ( 2 (sensitivity=78.2%, specificity=70.0%). It also had a graduated threshold value (>3, sensitivity=71.1%, specificity=62.5%) in distinguishing intermediate-high SS than low SS groups. In predicting both the presence and severity of CAD, the MAPH score exhibited superior diagnostic performance relative to the levels of LSR and HSR. Conclusion: In patients with suspected CAD, a gradual increase in the MAPH score demonstrated significant diagnostic performance in distinguishing both the presence and severity of CAD. In these patients, the MAPH score may serve as a potential screening tool and can be utilized for risk stratification.

Özet

Amaç: Artan kanıtlar, kan viskozitesinin aterosklerozun hem gelişiminde hem de hızlanmasında önemli bir rol oynadığını göstermektedir. Bu çalışmada, şüpheli KAH'li hastalarda KAH'ın varlığını ve şiddetini tahmin etmede MAPH skorunun, yeni bir kan viskozitesi indeksi olan tanısal performansını incelemeyi amaçladık. Metot: Koroner anjiyografi geçiren 431 hasta retrospektif olarak değerlendirildi. SYNTAX skoru (SS), 3 gruba ayrıldı; düşük grup ( 2 idi (duyarlılık=78.2%, özgüllük=70.0%). Ayrıca, düşük SS gruplarından orta-yüksek SS gruplarını ayırt etmede dereceli eşik değeri vardı (>3, duyarlılık=71.1%, özgüllük=62.5%). Hem KAH'ın varlığını hem de şiddetini tahmin etmede, MAPH skoru LSR ve HSR seviyelerine göre üstün tanısal performans sergiledi. Sonuç: Şüpheli KAH'li hastalarda, MAPH skorundaki kademeli artış, hem KAH'ın varlığını hem de şiddetini ayırt etmede önemli bir tanısal performans gösterdi. Bu hastalarda, MAPH skoru potansiyel bir tarama aracı olarak hizmet verebilir ve risk stratifikasyonu için kullanılabilir.

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Cite This Article

Kıvrak, A., Yıldırım, A. (2024). Diagnostic performance of whole blood viscosity indices in predicting the presence and severity of coronary artery disease. Journal of Medicine and Palliative Care, Volume: 5 Issue: 1. https://doi.org/10.47582/jompac.1424294

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