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Journals / Journal of Medicine and Palliative Care / 2026 / Volume: 6 Issue: 5

Clinicopathologic profile of synchronous tumors in patients undergoing surgery for gynecologic malignancy: a retrospective single-center study

Jinekolojik malignite nedeniyle cerrahi uygulanan hastalarda senkron tümörlerin klinikopatolojik profili: retrospektif tek merkezli çalışma

Işık Sözen(Başakşehir Çam ve Sakura Şehir Hastanesi, Jinekolojik Onkoloji Cerrahisi)0000-0002-7733-9171
Gözde Şahin(Başakşehir Çam ve Sakura Şehir Hastanesi, Jinekolojik Onkoloji Cerrahisi)0000-0003-3067-9125
Can Berk Karabudak(Department of Obstetrics and Gynecology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey)0009-0001-7609-0626
Aidana Sharip Kyzy(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0009-0004-2495-261X
İlayda Aksoy(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0009-0005-6371-0792
Yahya Özgün Öner(Başakşehir Çam ve Sakura Şehir Hastanesi, Jinekolojik Onkoloji Cerrahisi)0000-0002-6215-7025
Başak Özge Kayan(Başakşehir Çam ve Sakura Şehir Hastanesi, Jinekolojik Onkoloji Cerrahisi)0000-0003-0699-0482
Fatma Benli Tanrıkulu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-6072-644X
Tolga Çiftpınar(Department of Gynecologic Oncology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey)0000-0001-7406-0629
İlkbal Temel(Başakşehir Çam ve Sakura Şehir Hastanesi, Jinekolojik Onkoloji Cerrahisi)0000-0002-7337-9977
Pages
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Publication Date
2025-10-24
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although SEOC is typically detected at an early stage, there was significant concordance between synchronous tumors in terms of both histology and staging.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: This study aimed to characterize tumor types and clinicopathological features of synchronous tumors in women operated for gynecologic malignancies.
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Key Findings & Data:Methods: This retrospective, single-center study included 20 consecutive patients with a pathological diagnosis of synchronous tumors.
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Conclusion & Impact:Although SEOC is typically detected at an early stage, there was significant concordance between synchronous tumors in terms of both histology and staging.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Synchronous tumors · endometrial cancer · ovarian cancer

Abstract

Aims: This study aimed to characterize tumor types and clinicopathological features of synchronous tumors in women operated for gynecologic malignancies. Methods: This retrospective, single-center study included 20 consecutive patients with a pathological diagnosis of synchronous tumors. Patient demographics, HPV/cytology findings, surgical procedures, histopathological features, treatment modalities, and early outcomes (recurrence and mortality) were collected and analyzed. Results: Mean age was 60.3 years and mean BMI was 31.6 kg/m². Hypertension and diabetes were each present in 35%. Most were HPV-negative (90%); cytology was negative in 65% (abnormalities: ASC-US 20%, ASC-H 5%, HSIL 10%). Synchronous endometrial and ovarian carcinoma (SEOC) was observed in 80% of the patients. The majority of patients had endometrioid adenocarcinoma (EAC). Among SEOC patients, 62.5% had stage I–II tumors. In these cases, histological concordance between synchronous tumors was 62.5%, while staging concordance was 75%. Conclusion: SEOC predominated with high histologic concordance between synchronous tumors. Although SEOC is typically detected at an early stage, there was significant concordance between synchronous tumors in terms of both histology and staging.

Özet

Amaç: Bu çalışmanın amacı jinekolojik maligniteler nedeniyle ameliyat edilen kadınlarda senkron tümörlerin türlerini ve klinikopatolojik özelliklerini tanımlamaktı. Yöntemler: Bu retrospektif tek merkezli çalışmaya patolojik olarak eş zamanlı tümör tanısı almış ardışık 20 hasta dahil edildi. Hastaların demografik verileri, HPV/sitoloji bulguları, cerrahi prosedürler, histopatolojik bulguları, tedavi tipleri ve erken dönem sonuçları (nüks, mortalite) incelendi ve analiz edildi. Bulgular: Ortalama yaş 60,3 yıl ve ortalama BKİ 31,6 kg/m² idi. Hipertansiyon ve diyabet oranı her biri için %35 idi. Çoğu hastada HPV negatifti (%90); sitoloji %65'inde negatifti (anormallikler: ASC-US %20, ASC-H %5, HSIL %10). Hastaların %80'inde senkron endometrial ve over karsinomu (SEOC) gözlendi. Hastaların çoğunda endometrioid adenokarsinom vardı. SEOC hastaların %62,5'inde evre I-II tümörler vardı ve bu vakalarda tümörler arasındaki histolojik uyum %62,5 evreleme uyumu %75 idi. Sonuç: SEOC, senkron tümörler arasında yüksek histolojik uyumla ön plana çıkmıştır. SEOC genellikle erken evrede tespit edilse de, hem histoloji hem de evreleme açısından senkron tümörler arasında önemli bir uyum vardı.

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Cite This Article

Sözen, I., Şahin, G., Karabudak, C. B., Kyzy, A. S., Aksoy, İ., Öner, Y. Ö., Kayan, B. Ö., Tanrıkulu, F. B., Çiftpınar, T., Temel, İ. (2025). Clinicopathologic profile of synchronous tumors in patients undergoing surgery for gynecologic malignancy: a retrospective single-center study. Journal of Medicine and Palliative Care, Volume: 6 Issue: 5. https://doi.org/10.47582/jompac.1774720

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