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Journals / Journal of Medicine and Palliative Care / 2026 / Volume: 7 Issue: 2

Experimental assessment of an elderberry-enriched carboxymethyl chitosan gel in a rat gingival defect model: local and systemic tolerance with histological findings

Bilge Cansu Uzun Saylan(DOKUZ EYLÜL ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ)0000-0002-4896-3864
Osman Yılmaz(DOKUZ EYLUL UNIVERSITY)0000-0001-7817-7576
Aylin Ziylan(DOKUZ EYLUL UNIVERSITY)0000-0003-4137-5696
Safiye Aktaş(DOKUZ EYLUL UNIVERSITY)0000-0002-7658-5565
Gizem Baysan(DOKUZ EYLUL UNIVERSITY)0000-0002-3195-9156
Özde Elif Gökbayrak(DOKUZ EYLUL UNIVERSITY)0000-0002-8765-0641
Oylum Çolpankan Güneş(DOKUZ EYLUL UNIVERSITY)0000-0002-2440-3256
Hasan Havıtçıoğlu(DOKUZ EYLUL UNIVERSITY)0000-0001-8169-3539
Pages
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Publication Date
2026-03-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The elderberry-enriched CMCht gel showed favorable histological healing without inflammatory infiltration or systemic adverse effects, supporting its potential as a locally well-tolerated topical biomaterial with anti-inflammatory properties for gingival wound applications.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: The local and systemic effects of an elderberry-enriched carboxymethyl chitosan (CMCht-E) gel formulation were evaluated in an experimental rat gingival defect model.
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Key Findings & Data:Standardized gingival defects measuring 3 mm in diameter were surgically created in the mandibular incisor region.
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Conclusion & Impact:Conclusion: The elderberry-enriched CMCht gel showed favorable histological healing without inflammatory infiltration or systemic adverse effects, supporting its potential as a locally well-tolerated topical biomaterial with anti-inflammatory properties for gingival wound applications.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Elderberry extract · carboxymethyl chitosan · gingival defect

Abstract

Aims: The local and systemic effects of an elderberry-enriched carboxymethyl chitosan (CMCht-E) gel formulation were evaluated in an experimental rat gingival defect model. Methods: Twenty-one male Wistar rats were randomly assigned to three experimental groups, including a sham group, a CMCht gel group, and a CMCht-E gel group, with seven animals in each group. Standardized gingival defects measuring 3 mm in diameter were surgically created in the mandibular incisor region. Sham defects were irrigated with normal saline only, whereas experimental defects were treated with CMCht or CMCht-E gel. Local tissue responses were evaluated by macroscopic and histological analyses, and systemic effects were assessed using hematological and serum biochemical parameters. Results: Histological analysis revealed a significant intergroup difference in epithelial thickness (p 0.05). Hematological and biochemical parameters showed no significant intergroup differences (p>0.05). Conclusion: The elderberry-enriched CMCht gel showed favorable histological healing without inflammatory infiltration or systemic adverse effects, supporting its potential as a locally well-tolerated topical biomaterial with anti-inflammatory properties for gingival wound applications.

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Cite This Article

Saylan, B. C. U., Yılmaz, O., Ziylan, A., Aktaş, S., Baysan, G., Gökbayrak, Ö. E., Güneş, O. Ç., Havıtçıoğlu, H. (2026). Experimental assessment of an elderberry-enriched carboxymethyl chitosan gel in a rat gingival defect model: local and systemic tolerance with histological findings. Journal of Medicine and Palliative Care, Volume: 7 Issue: 2. https://doi.org/10.47582/jompac.1867014

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