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Journals / Journal of Health Sciences and Medicine / 2026 / Volume: 6 Issue: 5

Evaluation of the relationship between mitral annular calcification and triglyceride-glucose index

Gökhan Gökalp(Pursaklar State Hospital, Department of Cardiology Clinic, Ankara, Turkey)0000-0002-4958-7266
Nail Burak Özbeyaz(Pursaklar State Hospital, Department of Cardiology Clinic, Ankara, Turkey)0000-0002-7132-4286
Murat Oguz Özilhan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALI)0000-0003-4801-966X
Pages
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Publication Date
2023-09-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further extensive studies are necessary to determine the importance and use of TyG in MAC.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aims: Mitral annular calcification (MAC) is an echocardiographic condition with a multicomponent etiopathogenesis, one of which is insulin resistance.
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Key Findings & Data:Methods: The study included 159 patients with MAC and 167 control group.
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Conclusion & Impact:Further extensive studies are necessary to determine the importance and use of TyG in MAC.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mitral annular calcification · insulin resistance · triglyceride-glucose index

Abstract

Aims: Mitral annular calcification (MAC) is an echocardiographic condition with a multicomponent etiopathogenesis, one of which is insulin resistance. Triglyceride-glucose (TyG) index is an excellent biochemical parameter that has proven itself in determining insulin resistance in recent years. This study aims to reveal the relationship between the TyG index and the presence of MAC. Methods: The study included 159 patients with MAC and 167 control group. The control group has similar demographic characteristics such as age, gender, presence of hypertension (HT), and diabetes mellitus with the MAC group. TyG index was calculated as a formula: ln[fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. Results: The mean age of the patients was 74.2 and 48.2% of the patients were male. Coronary artery disease (CAD) (p: 0.031), glucose (p:0.001), total cholesterol (p:0.009), low-density lipoprotein (LDL) (p:0.004), triglyceride (TG) (p <0.001) levels and TyG index (p <0.001) were higher in MAC group. In the multivariate regression analysis, TG (p:0.004) and TyG index (p<0.001) were found to be independent risk factors. As a result of the ROC analysis, the cut-off value for estimating MAC was found to be 8.81 [(sensitivity: 77.3%, specificity: 76.5%, AUC (95% CI) 0.756 (0.704-0.807) p<0.001)]. Conclusion: In this study, a high TyG index was found to be an independent risk factor for MAC. The TyG index was found to be a better biomarker than TG and glucose alone in predicting MAC. Further extensive studies are necessary to determine the importance and use of TyG in MAC.

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Cite This Article

Gökalp, G., Özbeyaz, N. B., Özilhan, M. O. (2023). Evaluation of the relationship between mitral annular calcification and triglyceride-glucose index. Journal of Health Sciences and Medicine, Volume: 6 Issue: 5. https://doi.org/10.32322/jhsm.1345325

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