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Journals / Izmir Democracy University Health Sciences Journal / 2026 / Cilt: 8 Sayı: 1

TREATMENT OPTIONS FOR ARRHYTHMIA IN CATS AND DOGS

KEDİ VE KÖPEKLERDE ARİTMİNİN SAĞALTIM SEÇENEKLERİ

Bülent Burak Doğan(ANKARA UNIVERSITY)0009-0006-8782-2702
Ali Bilgili(Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Ankara, Turkey)0000-0001-6819-7952
Pages
1–24
Publication Date
2025-05-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

By extensively analyzing scientific sources of recent years, comprehensive information about the most commonly used drugs in treatment has been given in order to facilitate the clinician veterinarians in terms of application.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Rhythm irregularities in the heart, cardiac arrhythmias, are caused by abnormalities in the generation or conduction of impulses, or both.
📊
Key Findings & Data:Abnormal impulses generated outside the SA node in the heart are called ectopic impulses.
💡
Conclusion & Impact:By extensively analyzing scientific sources of recent years, comprehensive information about the most commonly used drugs in treatment has been given in order to facilitate the clinician veterinarians in terms of application.
🔬Design:Derleme
📍Scope:Comprehensive Sample
⚙️Variables:Kedi · köpek · kalp

Abstract

Rhythm irregularities in the heart, cardiac arrhythmias, are caused by abnormalities in the generation or conduction of impulses, or both. Abnormal impulses generated outside the SA node in the heart are called ectopic impulses. Ectopic impulses may originate from the atrium, junction or ventricle and are named accordingly as atrial, junctional, supraventricular or ventricular ectopic beats. Arrhythmia can be of cardiac or non-cardiac origin. Arrhythmia in cats and dogs cause high mortality rates. The use of anti-arrhythmic drugs in cats and dogs with arrhythmia provides a positive improvement in clinical signs and prolongs their life expectancy. Within the scope of this study, the aetiology, prevalence, clinical findings, diagnosis, clinical reports and drugs used in the treatment of arrhythmias were comprehensively discussed. By extensively analyzing scientific sources of recent years, comprehensive information about the most commonly used drugs in treatment has been given in order to facilitate the clinician veterinarians in terms of application.

Özet

Kalpteki ritim düzensizlikleri, kardiyak aritmiler uyarı oluşumundaki veya iletimindeki ya da her ikisindeki anormalliklerden kaynaklanır. Kalpte SA düğüm dışında üretilen anormal impulslara ektopik impulslar denir. Ektopik impulslar kökenini atriyum, kavşak veya ventrikülden alabilir ve buna göre atriyal, kavşak, supraventriküler veya ventriküler ektopik atımlar şeklinde isimlendirilir. Aritmi, kardiyak kökenli veya kardiyak kökenli olmayan biçimlerde olabilir. Kedi ve köpeklerde aritmi yüksek ölüm oranlarına neden olmaktadır. Aritmi gelişen kedi ve köpeklerde anti aritmik ilaçların kullanılması klinik belirtilerde olumlu gelişme sağlar ve yaşam sürelerini uzatır. Bu çalışma kapsamında aritmilerin etiyoloji, prevalans, klinik bulgular, tanı, klinik bildirimler ve aritmilerin sağaltımında kullanılan ilaçlar kapsamlı şekilde ele alındı. Son yıllara ait bilimsel kaynaklar geniş şekilde irdelenerek klinisyen veteriner hekimlere uygulama yönünden kolaylık sağlaması bakımından, sağaltımda en çok kullanılan ilaçlar hakkında kapsamlı bilgiler verildi.

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Cite This Article

Doğan, B. B., Bilgili, A. (2025). TREATMENT OPTIONS FOR ARRHYTHMIA IN CATS AND DOGS. Izmir Democracy University Health Sciences Journal, Cilt: 8 Sayı: 1, 1–24. https://doi.org/10.52538/iduhes.1655179

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References (86)

  1. Aptekmann, K. P., Vailati, M. D. C. F., Fortuna, T. D. O. M., Schwartz, D. S. (2010). Prevalence of cardiac arrhythmias and conduction disturbances in dogs and cats in Botucatu, Brazil (2003-2007). Brazilian Journal of Veterinary Research and Animal Science, 47(5), 371-379.
  2. Arcuri, G., Valente, C., Perini, C., Guglielmini, C. (2024). Risk factors for atrial fibrillation in the dog: A systematic review. Veterinary Sciences, 11(1), 47.
  3. Barr, S. C., Holmes, R. A., Klei, T. R. (1992). Electrocardiographic and echocardiographic features of trypanosomiasis in dogs inoculated with North American Trypanosoma cruzi isolates. American Journal of Veterinary Research, 53(4), 521-527. https://doi.org/https://doi.org/10.2460/ajvr.1991.53.04.521
  4. Bartnicki, M., Lyp, P., Debiak, P., Staniec, M., Winiarczyk, S., Buczek, K., Adaszek, L. (2017). Cardiac disorders in dogs infected with Babesia canis. Polish Journal of Veterinary Sciences, 20(3), 573-581. https://doi.org/10.1515/pjvs-2017-0070
  5. Beer, K. S., Balakrishnan, A., Hart, S. K. (2019). Successful management of persistent tachycardia using esmolol in 2 dogs with septic shock. Journal of Veterinary Emergency and Critical Care, 29(3), 326-330.
  6. Berlin, N., Ohad, D. G., Maiorkis, I., Kelmer, E. (2020). Successful management of ventricular fibrillation and ventricular tachycardia using defibrillation and intravenous amiodarone therapy in a cat. Journal of Veterinary Emergency and Critical Care, 30, 474-480. https://doi.org/10.1111/vec.12960
  7. Borgeat, K., Pack, M., Harris, J., Laver, A., Seo, J., Belachsen, O., Hannabuss, J., Todd, J., Ferasin, L., Payne, J. R. (2021). Prevalence of sudden cardiac death in dogs with atrial fibrillation. Journal of Veterinary Internal Medicine, 35(6), 2588-2595. https://doi.org/10.1111/jvim.16297
  8. Burashnikov, A., Di Diego, J. M., Barajas-Martinez, H., Hu, D., Cordeiro, J. M., Moise, N. S., Kornreich, B. G., Belardinelli, L., Antzelevitch, C. (2014). Ranolazine effectively suppresses atrial fibrillation in the setting of heart failure. Circulation: Heart Failure, 7(4), 627-633. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001129
  9. Burashnikov, A., Di Diego, J. M., Patocskai, B., Echt, D. S., Belardinelli, L., Antzelevitch, C. (2024). Effect of flecainide and ibutilide alone and in combination to terminate and prevent recurrence of atrial fibrillation. Circulation: Arrhythm and Electrophysiology, 17, e012454. https://doi.org/10.1161/CIRCEP.123.012454
  10. Chaudhuri, S., Varshney, J., Chaugkija, B. (2017). Electrocardiographic changes in canine babesiosis. Archives of Palliative Care, 2(2), 1014.
  11. Chokesuwattanaskul, R., Shah, N., Chokesuwattanaskul, S., Liu, Z., Thakur, R. (2020). Low-dose amiodarone is safe: A systematic review and meta-analysis. The Journal of Innovations in Cardiac Rhythm Management, 11(4), 4054-4061. https://doi.org/10.19102/icrm.2020.110403
  12. Colella, A., Digiaro, S., Fiorentino, M., Greco, B., Sasanelli, M., Paradies, P. (2022). Serum digoxin concentrations in dogs with atrial fibrillation under long term digoxin treatment. Open Veterinary Journal, 12(3), 360-369. https://doi.org/10.5455/OVJ.2022.v12.i3.9
  13. Crofton, A. E., Kovacs, S. L., Stern, J. A. (2023). Subvalvular aortic stenosis: Learning from human and canine clinical research. Cardiology Research, 14(5), 319-333. https://doi.org/10.14740/cr1547
  14. Crosara, S., Borgarelli, M., Perego, M., Haggstrom, J., La Rosa, G., Tarducci, A., Santilli, R. A. (2010). Holter monitoring in 36 dogs with myxomatous mitral valve disease. Australian Veterinary Journal, 88(10), 386-392. https://doi.org/10.1111/j.1751-0813.2010.00628.x
  15. Çolakoğlu, E. Ç., Sevim, K., Kalınbacak, A. (2021). Köpek ve kedilerde ritim-iletim bozuklukları. Turkiye Klinikleri Veterinary Sciences-Internal Medicine-Special Topics, 7(3), 123-128.
  16. Daniel, A. K., David, V. P., Sindhu, O. K., Madhavan Unny, N. (2023). Successful management of ventricular premature contractions in a dog with combination therapy of mexiletine and sotalol. Indian Journal of Animal Health, 62(1), 222-223. https://doi.org/10.36062/ijah.2023.17022
  17. de Almeida, G. L. G., de Almeida, M. B., dos Santos, A. C. M., Vargas, Â., Ballot, S., Souza, E. W. (2022). Digoxin for atrial fibrillation: good, but not too good: a case report. Acta Veterinaria Brasilica, 16, 185-189. https://doi.org/http://dx.doi.org/10.21708/avb.2022.16.3.10837
  18. Eason, B. D., Fine-Ferreira, D. M., Leeder, D., Stauthammer, C., Lamb, K., Tobias, A. (2021). Natural history of subaortic stenosis in 166 dogs (1999-2011). Journal of Veterinary Cardiology, 37, 71-80. https://doi.org/10.1016/j.jvc.2021.08.005
  19. Freid, K. J., Freeman, L. M., Rush, J. E., Cunningham, S. M., Davis, M. S., Karlin, E. T., Yang, V. K. (2021). Retrospective study of dilated cardiomyopathy in dogs. Journal of Veterinary Internal Medicine, 35, 58-67. https://doi.org/10.1111/jvim.15972
  20. Freitas da Silva, J.F. (2018). Chapter 17. Anti-arrhythmic drugs. In: Willis, R., Oliveira, P., Mavropoulou, A. (eds.), Guide to Canine and Feline Electrocardiography, John Wiley and Sons, Inc., USA, p. 241-254.
  21. Friederich, J., Seuß, A., Wess, G. (2020). The role of atrial fibrillation as a prognostic factor in doberman pinschers with dilated cardiomyopathy and congestive heart failure. The Veterinary Journal, 264, 105535. https://doi.org/ https://doi.org/10.1016/j.tvjl.2020.105535
  22. Gianfranchesco Filippi, M., de Castro Ferreira Lima, M., Paes, A. C., Sarita Cruz Aleixo, A., Oba, E., Ferreira de Souza, F., Kiomi Takahira, R., Gomes Lourenco, M. L. (2019). Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis. PLoS One, 14(5), e0216552. https://doi.org/10.1371/journal.pone.0216552
  23. Gonzalez-Vieyra, S. D., Ramirez-Duran, N., Sandoval-Trujillo, A. H., Vazquez-Chagoyan, J. C., Monroy-Salazar, H. G., Barbabosa-Pliego, A. (2011). Trypanosoma cruzi in dogs: electrocardiographic and echocardiographic evaluation, in Malinalco, State of Mexico. Research and Reports in Tropical Medicine, 2, 155-161. https://doi.org/10.2147/RRTM.S21683
  24. Greet, V., Sargent, J., Brannick, M., Fuentes, V. L. (2020). Supraventricular tachycardia in 23 cats; comparison with 21 cats with atrial fibrillation (2004-2014). Journal of Veterinary Cardiology, 30, 7-16. https://doi.org/10.1016/j.jvc.2020.04.007
  25. Guglielmini, C., Goncalves Sousa, M., Baron Toaldo, M., Valente, C., Bentivoglio, V., Mazzoldi, C., Bergamin, I., Drigo, M., Poser, H. (2020). Prevalence and risk factors for atrial fibrillation in dogs with myxomatous mitral valve disease. Journal of Veterinary Internal Medicine, 34, 2223-2231. https://doi.org/10.1111/jvim.15927
  26. Guieu, R., Deharo, J. C., Maille, B., Crotti, L., Torresani, E., Brignole, M., Parati, G. (2020). Adenosine and the cardiovascular system: The good and the bad. Journal of Clinical Medicine, 9(5), 1366. https://doi.org/10.3390/jcm9051366
  27. Guler, S., Konemann, H., Wolfes, J., Guner, F., Ellermann, C., Rath, B., Frommeyer, G., Lange, P. S., Kobe, J., Reinke, F., Eckardt, L. (2023). Lidocaine as an anti-arrhythmic drug: Are there any indications left? Clinical and Translational Science, 16, 2429-2437. https://doi.org/10.1111/cts.13650
  28. Holdt, S. L., Peckens, N. K., Rosenthal, S., Cober, R. (2022). Arrhythmogenic right ventricular cardiomyopathy in Bulldogs: Evaluation of clinical and histopathologic features, progression, and outcome in 71 dogs (2004-2016). Journal of Veterinary Cardiology, 40, 170-183. https://doi.org/10.1016/j.jvc.2021.10.003
  29. Ide, T., Ohtani, K., Higo, T., Tanaka, M., Kawasaki, Y., Tsutsui, H. (2019). Ivabradine for the treatment of cardiovascular diseases. Circulation Journal, 83, 252-260. https://doi.org/10.1253/circj.CJ-18-1184
  30. Jackson, B. L., Lehmkuhl, L. B., Adin, D. B. (2014). Heart rate and arrhythmia frequency of normal cats compared to cats with asymptomatic hypertrophic cardiomyopathy. Journal of Veterinary Cardiology, 16, 215-225. https://doi.org/10.1016/j.jvc.2014.10.001
  31. Janus, I., Noszczyk-Nowak, A., Nowak, M., Cepiel, A., Ciaputa, R., Paslawska, U., Dziegiel, P., Jablonska, K. (2014). Myocarditis in dogs: etiology, clinical and histopathological features (11 cases: 2007-2013). Irish Veterinary Journal, 67(1), 28. https://doi.org/10.1186/s13620-014-0028-8
  32. Karnina, R., Arif, S. K., Hatta, M., Bukhari, A. (2021). Molecular mechanisms of lidocaine. Annals of Medicine and Surgery, 69, 102733. https://doi.org/10.1016/j.amsu.2021.102733
  33. Keene, B. W., Atkins, C. E., Bonagura, J. D., Fox, P. R., Haggstrom, J., Fuentes, V. L., Oyama, M. A., Rush, J. E., Stepien, R., Uechi, M. (2019). ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. Journal of Veterinary Internal Medicine, 33(3), 1127-1140. https://doi.org/10.1111/jvim.15488
  34. Kohajda, Z., Virag, L., Hornyik, T., Husti, Z., Sztojkov-Ivanov, A., Nagy, N., Horvath, A., Varga, R., Prorok, J., Szlovak, J., Toth, N., Gazdag, P., Topal, L., Naveed, M., Arpadffy-Lovas, T., Paszti, B., Magyar, T., Koncz, I., Deri, S., Varro, A. (2022). In vivo and cellular antiarrhythmic and cardiac electrophysiological effects of desethylamiodarone in dog cardiac preparations. British Journal of Pharmacology, 179, 3382-3402. https://doi.org/10.1111/bph.15812
  35. Lakhdhir, S., Viall, A., Alloway, E., Keene, B., Baumgartner, K., Ward, J. (2020). Clinical presentation, cardiovascular findings, etiology, and outcome of myocarditis in dogs: 64 cases with presumptive antemortem diagnosis (26 confirmed postmortem) and 137 cases with postmortem diagnosis only (2004-2017). Journal of Veterinary Cardiology, 30, 44-56. https://doi.org/10.1016/j.jvc.2020.05.003
  36. Le, D. E., Davis, C. M., Wei, K., Zhao, Y., Cao, Z., Nugent, M., Scott, K. L. L., Liu, L., Nagarajan, S., Alkayed, N. J., Kaul, S. (2020). Ranolazine may exert its beneficial effects by increasing myocardial adenosine levels. American Journal of Physiology. Heart and Circulatory Physiology, 318, H189-H202. https://doi.org/10.1152/ajpheart.00217.2019
  37. Ledwitch, K. V., Barnes, R. W., Roberts, A. G. (2016). Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein. Bioscience Reports, 36, e00309. https://doi.org/10.1042/BSR20150317
  38. Levy, N. A., Koenigshof, A. M., Sanders, R. A. (2016). Retrospective evaluation of intravenous premixed amiodarone use and adverse effects in dogs (17 cases: 2011-2014). Journal of Vetetinary Cardiology, 18(1), 10-14. https://doi.org/10.1016/j.jvc.2015.10.009
  39. Li, Y. D., Ji, Y. T., Zhou, X. H., Jiang, T., Hong, Y. F., Li, J. X., Xing, Q., Xiong, J., Yusufuaji, Y., Tang, B. P. (2015). Effects of ivabradine on cardiac electrophysiology in dogs with age-related atrial fibrillation. Medical Science Monitor, 21, 1414-1420. https://doi.org/10.12659/MSM.894320
  40. Liao, J., Xiong, Q., Yin, Y., Ling, Z., Chen, S. (2021). The effects of fish oil on cardiovascular diseases: Systematical evaluation and recent advance. Frontiers in Cardiovascular Medicine, 8, 802306. https://doi.org/10.3389/fcvm.2021.802306
  41. Lima, M. d. C. F., de Araújo, J. B. C., Paes, A. C., Filippi, M. G., Cruz-Aleixo, A. S., Takahira, R. K., Lourenço, M. L. G. (2019). Conventional and holter electrocardiographic assessment of dogs infected naturally with acute canine monocytic ehrlichiosis. Topics in Companion Animal Medicine, 35, 31-37. https://doi.org/http://dx.doi.org/10.1053/j.tcam.2019.03.005
  42. Lobetti, R. G. (2005). Cardiac involvement in canine babesiosis. Journal of the South African Veterinary Association, 76(1), 4-8. https://doi.org/10.4102/jsava.v76i1.386
  43. Mar, P. L., Horbal, P., Chung, M. K., Dukes, J. W., Ezekowitz, M., Lakkireddy, D., Lip, G. Y. H., Miletello, M., Noseworthy, P. A., Reiffel, J. A., Tisdale, J. E., Olshansky, B., Gopinathannair, R., from the American Heart Association, E., Arrhythmias Committee of the Council of Clinical, C. (2022). Drug interactions affecting antiarrhythmic drug use. Circulation: Arrhythmia and Electrophysiology, 15, e007955. https://doi.org/10.1161/CIRCEP.121.007955
  44. Matos, J. N., Silva, J., Regada, S., Rizzo, S., Beato, M. S., Basso, C. (2024). Hypertrophic cardiomyopathy in a dog: a systematic diagnostic approach. Journal of Veterinary Cardiology, 51, 1-8. https://doi.org/https://doi.org/10.1016/j.jvc.2023.10.002
  45. Matthews, D. J., Saunders, A. B., Meyers, A. C., Gordon, S. G., Hamer, S. A. (2021). Cardiac diagnostic test results and outcomes in 44 dogs naturally infected with Trypanosoma cruzi. Journal of Veterinary Internal Medicine, 35(4), 1800-1809. https://doi.org/10.1111/jvim.16166
  46. Mavropoulou, A. (2018). Chapter 11. Ventricular Rhythms. In: Willis, R., Oliveira, P., Mavropoulou, A. (eds.), Guide to Canine and Feline Electrocardiography, John Wiley and Sons, Inc., USA, p. 169-188.
  47. Meurs, K.M., Riviere, J.E. (2018). Chapter 22. Antiarrhythmic agents. In: Riviere, J. E., Papich, M. G. (eds), Veterinary Pharmacology and Therapeutics, Tenth Edition, John Wiley and Sons, p. 537-551.
  48. Meyers, A. C., Ellis, M. M., Purnell, J. C., Auckland, L. D., Meinders, M., Saunders, A. B., Hamer, S. A. (2020). Selected cardiac abnormalities in Trypanosoma cruzi serologically positive, discordant, and negative working dogs along the Texas-Mexico border. BMC Veterinary Research, 16, 101. https://doi.org/10.1186/s12917-020-02322-6
  49. Mujovic, N., Dobrev, D., Marinkovic, M., Russo, V., Potpara, T. S. (2020). The role of amiodarone in contemporary management of complex cardiac arrhythmias. Pharmacological Research, 151, 104521. https://doi.org/10.1016/j.phrs.2019.104521
  50. Nasciutti, P. R., Moraes, A. T., Santos, T. K., Goncalves Queiroz, K. K., Costa, A. P. A., Amaral, A. R., Fernando Gomes Olivindo, R., Pontieri, C. F. F., Jeremias, J. T., Vendramini, T. H. A., Brunetto, M. A., Carvalho, R. O. A. (2021). Protective effects of omega-3 fatty acids in dogs with myxomatous mitral valve disease stages B2 and C. PLoS One, 16(7), e0254887. https://doi.org/10.1371/journal.pone.0254887
  51. Noszczyk-Nowak, A., Michałek, M., Kałuża, E., Cepiel, A., Pasławska, U. (2017). Prevalence of arrhythmias in dogs examined between 2008 and 2014. Journal of Veterinary Research, 61(1), 103-110. https://doi.org/10.1515/jvetres-2017-0013
  52. Ohmori, T., Matsumura, Y., Yoshimura, A., Morita, S., Hasegawa, H., Hirao, D., Fukushima, R. (2022). Efficacy of cilostazol in canine bradyarrhythmia. Frontiers and Veterinary Science, 9, 954295. https://doi.org/10.3389/fvets.2022.954295
  53. Oliveira, P. (2018). Chapter 1. Anatomy of the Conduction System In: Willis, R., Oliveira, P., Mavropoulou, A. (eds.), Guide to Canine and Feline Electrocardiography, John Wiley and Sons, Inc., USA, p. 1-8.
  54. Owens, E. J., LeBlanc, N. L., Treseder, J., Scollan, K. F. (2022). Echocardiographic and electrocardiographic effects of atenolol versus sotalol in dogs with severe subaortic stenosis. Journal of Veterinary Cardiology, 41, 199-208. https://doi.org/10.1016/j.jvc.2022.03.004
  55. Payne, J. R., Borgeat, K., Connolly, D. J., Boswood, A., Dennis, S., Wagner, T., Menaut, P., Maerz, I., Evans, D., Simons, V. E., Brodbelt, D. C., Luis Fuentes, V. (2013). Prognostic indicators in cats with hypertrophic cardiomyopathy. Journal of Veterinary Internal Medicine, 27(6), 1427-1436. https://doi.org/10.1111/jvim.12215
  56. Pedro, B., Fontes-Sousa, A. P., Gelzer, A. R. (2020a). Canine atrial fibrillation: Pathophysiology, epidemiology and classification. The Veterinary Journal, 265, 105548. https://doi.org/10.1016/j.tvjl.2020.105548
  57. Pedro, B., Fontes-Sousa, A. P., Gelzer, A. R. (2020b). Diagnosis and management of canine atrial fibrillation. The Veterinary Journal, 265, 105549. https://doi.org/10.1016/j.tvjl.2020.105549
  58. Petrič, A. D., Cvetko, S. (2009). Aortic stenosis in dogs: clinical characteristics and survival in 80 cases. Slovenian Veterinary Research/Slovenski Veterinarski Zbornik, 46(4), 125-131.
  59. Petrič, A. D. (2015). Myxomatous mitral valve disease in dogs-An update and perspectives. Macedonian Veterinary Review, 38(1), 13-20. https://doi.org/http://dx.doi.org/10.14432/j.macvetrev.2014.11.026
  60. Pirintr, P., Limprasutr, V., Saengklub, N., Pavinadol, P., Yapao, N., Limvanicharat, N., Kuecharoen, H., Kijtawornrat, A. (2018). Acute effect of ivabradine on heart rate and myocardial oxygen consumption in dogs with asymptomatic mitral valve degeneration. Experimental Animals, 67(4), 441-449. https://doi.org/10.1538/expanim.18-0030
  61. Qi, J., Jian, Z., Zhang, N., Lin, C.-j., Yang, P., Gang, G., Shen, W.-F., Wu, L.-Q. (2012). Ibutilide decreases defibrillation threshold by the reduction of activation pattern complexity during ventricular fibrillation in canine hearts. Chinese Medical Journal, 125(15), 2701-2707. https://doi.org/10.3760/cma.j.issn.0366-6999.2012.15.010
  62. Reagan, K. L., Visser, L. C., Epstein, S. E., Stern, J. A., Johnson, L. R. (2022). Outcome and prognostic factors in infective endocarditis in dogs: 113 cases (2005-2020). Journal of Veterinary Internal Medicine, 36(2), 429-440. https://doi.org/10.1111/jvim.16380
  63. Romito, G., Guglielmini, C., Mazzarella, M. O., Cipone, M., Diana, A., Contiero, B., Baron Toaldo, M. (2018). Diagnostic and prognostic utility of surface electrocardiography in cats with left ventricular hypertrophy. Journal of Veterinary Cardiology, 20(5), 364-375. https://doi.org/10.1016/j.jvc.2018.07.002
  64. Romito, G., Venturelli, E., Tintorri, V., Cipone, M. (2022). Reversible myocardial injury aggravated by complex arrhythmias in three Toxoplasma gondii-positive dogs. J Vet Med Sci, 84(2), 289-295. https://doi.org/10.1292/jvms.21-0571
  65. Romito, G., Gemma, N., Dondi, F., Mazzoldi, C., Fasoli, S., Cipone, M. (2024). Efficacy and safety of antiarrhythmic therapy in dogs with naturally acquired tachyarrhythmias treated with amiodarone or sotalol: a retrospective analysis of 64 cases. Journal of Veterinary Cardiology, 53, 20-35.
  66. Romito, G., Bertarello, M., Mazzoldi, C., Fasoli, S., Dondi, F., Castagna, P., Pelle, N., Paradies, P., Valente, C., Poser, H. (2025). Efficacy and safety of different antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation. Journal of Veterinary Cardiology, 57, 8-19. https://doi.org/https://doi.org/10.1016/j.jvc.2024.10.006
  67. Santilli, R. A., Battaia, S., Perego, M., Tursi, M., Grego, E., Marzufero, C., Gianella, P. (2017). Bartonella-associated inflammatory cardiomyopathy in a dog. Journal of Veterinary Cardiology, 19(1), 74-81. https://doi.org/10.1016/j.jvc.2016.07.005
  68. Santilli, R., Saponaro, V., Carlucci, L., Perego, M., Battaia, S., Borgarelli, M. (2021). Heart rhythm characterization during sudden cardiac death in dogs. Journal of Veterinary Cardiology, 38, 18-30. https://doi.org/10.1016/j.jvc.2021.09.005
  69. Sawyer, D., Gates, K. (2017). Severe lamotrigine toxicosis in a dog. Veterinary Medicine: Research and Reports, 8, 27-30. https://doi.org/10.2147/VMRR.S131583
  70. Schoeller, A. B., Rudloff, E., Waldner, C. L., Klose, T. C., Linklater, A. K. (2020). Preliminary evaluation of the efficacy of intravenous magnesium sulfate for the treatment of ventricular arrhythmias in 16 dogs. Journal of Veterinary Emergency and Critical Care, 30, 687-692. https://doi.org/10.1111/vec.13004
  71. Shumakov, V., Kletikova, L., Martynov, A., Khrushcheva, V. (2019). Clinical-laboratory manifestations of myocarditis in dogs. KnE Life Sciences, 820–832. https://doi.org/10.18502/kls.v4i14.5679
  72. Sun, J., Li, X., Guo, J., Liu, P., Zhang, P. (2011). Effects of ibutilide on inhibiting heart rate and rapidly terminating atrial flutter in canine. Cell Biochemistry and Biophysics, 59, 153-158. https://doi.org/10.1007/s12013-010-9126-8
  73. Szlosek, D. A., Castaneda, E. L., Grimaldi, D. A., Spake, A. K., Estrada, A. H., Gentile-Solomon, J. (2024). Frequency of arrhythmias detected in 9440 feline electrocardiograms by breed, age, and sex. Journal of Veterinary Cardiology, 51, 116-123. https://doi.org/10.1016/j.jvc.2023.11.004
  74. Tamargo, J., Caballero, R., Delpon, E. (2020). Chapter 3. Class III Antiarrhythmic drugs. In: Martinez-Rubio, A., Tamargo, J., Dan, G-A. (eds), Antiarrhythmic drugs, Springer Nature Switzerland AG, p. 107-180.
  75. Thakuria, P., Kalita, D., Phukan, A., Changkija, B., Dutta, D., Das, B., Baishya, B., Nath, R., Kalita, D., Das, A. (2018). Serum biochemical changes in arrhythmia in dogs. International Journal of Chemical Studies, 6(3), 3116-3118.
  76. Tilley, L.P., Smith, F.W.K. (2016). Chapter 3. Electrocardiography. In: Smith, F.K.S., Tilley, L.P., Oyama, M.A., Sleeper, M.M. (2016) (eds.), Manual of Canine and Feline Cardiology, Fifth Edition, Elsevier, China, p. 49-76.
  77. Tjostheim, S. S., Showers, A., Obernberger, C., Shear, M. (2023). Association of sotalol versus atenolol therapy with survival in dogs with severe subaortic stenosis. Journal of Veterinary Cardiology, 48, 19-30. https://doi.org/10.1016/j.jvc.2023.05.003
  78. Varshney, J., Deshmukh, V., Chaudhary, P. (2015). Evaluation of myocardial injury in acute canine monocytic ehrlichiosis. Intas Polivet, 16(2), 340-344.
  79. Varshney, J. (2020). Cardiac Arrhythmias. Electrocardiography in Veterinary Medicine, Springer, p. 101-136.
  80. Verschoor-Kirss, M., Rozanski, E., Rush, J. E. (2022). Use of esmolol for control of tachycardia in 28 dogs and cats (2003-2020). Journal of Veterinary Emergency and Critical Care, 32, 243-248. https://doi.org/10.1111/vec.13162
  81. Vlajkovic, S. M. (2024). Special Issue “Adenosine Receptors in Health and Disease”. International Journal of Molecular Sciences, 25, 12370. https://doi.org/10.3390/ijms252212370
  82. Vollmar, C., Vollmar, A., Keene, B., Fox, P. R., Reese, S., Kohn, B. (2019). Irish wolfhounds with subclinical atrial fibrillation: progression of disease and causes of death. Journal of Veterinary Cardiology, 24, 48-57. https://doi.org/10.1016/j.jvc.2019.05.004
  83. Ware, W. A., Bonagura, J. D. (2022). Cardiovascular Disease in Companion Animals: dog, cat and horse, 2nd edition, London, New York, CRC Press.
  84. Wess, G, Torti, M. (2018). Chapter 20. Arrhythmias in Canine Cardiomyopathies and Valvular Heart Disease. In: Willis, R., Oliveira, P., Mavropoulou, A. (eds.), Guide to Canine and Feline Electrocardiography, John Wiley and Sons, Inc., USA, p. 285-300.
  85. Wess, G. (2022). Screening for dilated cardiomyopathy in dogs. Journal of Veterinary Cardiology, 40, 51-68. https://doi.org/10.1016/j.jvc.2021.09.004
  86. Zhang, N., Luo, Q., Jin, Q., Han, Y., Huang, S., Wei, Y., Lin, C., Chen, K., Shen, W., Wu, L. (2020). Ibutilide reduces ventricular defibrillation threshold and organizes ventricular fibrillation activation in canine heart failure model. Cardiovascular Drugs and Therapy, 34, 323-334. https://doi.org/10.1007/s10557-020-06958-2