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Journals / International Journal of Traditional and Complementary Medicine Research / 2026 / Volume: 7 Issue: 1

Ozone Therapy and Its Applications: A Narrative Clinical Review

Kamile Marakoğlu(Selcuk University, Faculty of Medicine, Department of Family Medicine)0000-0002-6585-7019
Duygu İlke Yıldırım(Selcuk University, Faculty of Medicine, Department of Family Medicine)0000-0002-3893-5173
Esma Nakipoğlu(Selcuk University, Faculty of Medicine, Department of Family Medicine)0009-0006-7173-1486
Pages
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Publication Date
2026-04-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Research on standardization and dose optimization is ongoing to improve clinical efficacy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Ozone therapy induces oxidative stress and regulates cellular antioxidant defenses.
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Key Findings & Data:A literature search was conducted in PubMed, Scopus, and Google Scholar using the keywords “ozone therapy,” “medical ozone,” “oxygen–ozone therapy,” and “ozone applications.” Studies published between 2000 and 2025 were reviewed in this narrative clinical review in accordance with SANRA guidelines.
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Conclusion & Impact:Research on standardization and dose optimization is ongoing to improve clinical efficacy.
🔬Design:Review & Systematic Survey
📍Scope:2000 Verileri
⚙️Variables:Ozone therapy · autohemotherapy · oxidative stress

Abstract

Ozone therapy induces oxidative stress and regulates cellular antioxidant defenses. It can be administered using methods such as rectal insufflation, autohemotherapy, and local injection. A literature search was conducted in PubMed, Scopus, and Google Scholar using the keywords “ozone therapy,” “medical ozone,” “oxygen–ozone therapy,” and “ozone applications.” Studies published between 2000 and 2025 were reviewed in this narrative clinical review in accordance with SANRA guidelines. Due to its antimicrobial, anti-inflammatory, and immunomodulatory effects, ozone therapy has various indications ranging from infections to chronic inflammatory diseases. It is administered under medical supervision in accordance with legal regulations in many countries, including Türkiye. Research on standardization and dose optimization is ongoing to improve clinical efficacy.

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Cite This Article

Marakoğlu, K., Yıldırım, D. İ., Nakipoğlu, E. (2026). Ozone Therapy and Its Applications: A Narrative Clinical Review. International Journal of Traditional and Complementary Medicine Research, Volume: 7 Issue: 1. https://doi.org/10.53811/ijtcmr.1769358

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