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Journals / Acta Orthopaedica et Traumatologica Turcica / 2019 / Cilt: 53 - Sayı: 6

Locally administrated single-dose teriparatide affects critical-size rabbit calvarial defects: A histological, histomorphometric and micro-CT study

TAHA ÖZER
Özgür BAŞLARLI
ALPER AKTAŞ
EMRE BARIŞ
HAKAN HAMDİ ÇELİK
Mert OCAK
Pages
478–484
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In this study, rhPTH, which is used locally in defect areas to be repaired with bone grafts, increases both new bone volume and total bone volume.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to evaluate the effect of teriparatide (PTH 1-34, rhPTH) on a rabbit defect model with local xenogen grafts histomorphometrically and radiologically.
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Key Findings & Data:Methods: For this purpose, two 10 mm diameter critical-size defects were created in the calvaria of 16 rabbits.
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Conclusion & Impact:Conclusion: In this study, rhPTH, which is used locally in defect areas to be repaired with bone grafts, increases both new bone volume and total bone volume.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: The aim of this study was to evaluate the effect of teriparatide (PTH 1-34, rhPTH) on a rabbit defect model with local xenogen grafts histomorphometrically and radiologically. Methods: For this purpose, two 10 mm diameter critical-size defects were created in the calvaria of 16 rabbits. In the control group, the defect area was filled with a xenogen graft, while in the teriparatide group (PTH 1-34), a xenogen graft combination with 20 mcg teriparatide was used. For both 4 e week and 8 e week study groups, new bone, residual graft, and soft tissue areas were evaluated as well as bone volume histomorphometrically and radiologically. Results: Histomorphometrically, there was a significant difference in new bone area values at the 8th week (p 0.05). There was no statistically significant difference between the groups at both 4 and 8 weeks (p > 0.05). In the radiologically measured total bone volume values, PTH1-34 group values were found to be significantly higher for both 4 e and 8 e weeks values compared to the control groups (p < 0.05). Conclusion: In this study, rhPTH, which is used locally in defect areas to be repaired with bone grafts, increases both new bone volume and total bone volume.

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Cite This Article

ÖZER, T., BAŞLARLI, Ö., AKTAŞ, A., BARIŞ, E., ÇELİK, H. H., OCAK, M. (2019). Locally administrated single-dose teriparatide affects critical-size rabbit calvarial defects: A histological, histomorphometric and micro-CT study. Acta Orthopaedica et Traumatologica Turcica, Cilt: 53 - Sayı: 6, 478–484. https://ajindex.com/articles/149690

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