SavedAdd your journal

Journals / Ege Tıp Dergisi / 2016 / Cilt: 55 - Sayı: 2

Predictive factors for testicular sperm extraction (TESE) success in azoospermic cases with Klinefelter syndrome

Klinefelter sendromlu azospermik olgularda testiküler sperm ekstraksiyonu (TESE) başarısı için prediktif faktörler

Mehmet Zeynel KESKİN
Taha Reşi̇d ÖZDEMİR
Salih BUDAK
Yusuf Özlem İLBEY
Can KÖSE
Özge Özer KAYA
Pages
51–54
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

TESE success was found significantly higher at 32 years of age and under.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: It is aimed to identify the predictive factors for testicular sperm extraction (TESE) success in cases with Klinefelter syndrome (KS).
📊
Key Findings & Data:Materials and Methods: We retrospectively analyzed 322 patients that underwent TESE operation because of nonobstructive azoospermia (NOA) in our hospital between 2009 and 2014.
💡
Conclusion & Impact:TESE success was found significantly higher at 32 years of age and under.
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: It is aimed to identify the predictive factors for testicular sperm extraction (TESE) success in cases with Klinefelter syndrome (KS). Materials and Methods: We retrospectively analyzed 322 patients that underwent TESE operation because of nonobstructive azoospermia (NOA) in our hospital between 2009 and 2014. Twenty-nine patients whose genetic analysis reported 47XXY - KS were included in our study. Age, FSH, LH, FSH/LH ratio, prolactin, T and E2 values of these 29 patients were analysed retrospectively. In statistical analysis of these parameters, p value <0.05 was accepted as significant. Results: The mean age, FSH, LH, FSH/LH ratio, prolactin, T and E2 value of the patients were; 32 years, 38.4 mIU/mL, 18.84 mIU/mL, 2.04, 11 ng/mL, 216.74 ng/dL and 24.37 pg/mL, respectively. Our TESE success was 37.9 %. Age was the only predictive parameter for TESE success (p=0.007). Independent sample t test values of FSH, LH, FSH/LH ratio, prolactin, T and E2 were p=0.185; p=0.510; p=0.119; p=0.545; p=0.841; p=0.139 respectively and were non-predictive. Conclusion: In KS cases, the only predictive parameter for TESE success is age, except biopsy. TESE success was found significantly higher at 32 years of age and under.

Özet

Amaç: Klinefelter sendromu (KS) olgularında testiküler sperm ekstraksiyonu (TESE) başarısı için prediktif parametrelerin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Çalışmamızda hastanemizde 2009-2014 yıllarında non-obstrüktif azospermi (NOA) nedeniyle TESE yapılmış 322 hastanın verileri retrospektif olarak incelendi. Bu hastalardan genetik analizi 47XXY - KS olarak saptanan 29 hasta çalışmaya alınarak yaş, FSH, LH, FSH/LH oranı, prolaktin, T ve E2 değerleri retrospektif olarak incelendi. Parametrelerin istatistiksel analizinde, p<0.05 değeri anlamlı kabul edildi. Bulgular: Hastaların ortalama yaş, FSH, LH, FSH/LH oranı, Prolaktin, T ve E2 değerleri sırasıyla 32 yıl, 38.4 mIU/mL, 18.84 mIU/mL, 2.04, 11 ng/mL, 216.74 ng/dL ve 24.37 pg/mL olarak saptandı. TESE başarımız % 37.9 idi. TESE başarısını belirlemede etkili tek parametre yaş faktörüydü (p=0.007). FSH, LH, FSH/LH oranı, prolaktin, T ve E2 parametrelerinin bağımsız örneklem t test değerleri sırasıyla p=0.185, p=0.510, p=0.119, p=0.545, p=0.841, p=0.139 olarak bulundu ve non-prediktif oldukları görüldü. Sonuç: KS olgularında TESE başarısı için biyopsi dışında tek prediktif parametre yaştır. Otuz iki yaş ve altında TESE başarısı anlamlı derecede yüksektir.

🔖

Cite This Article

KESKİN, M. Z., ÖZDEMİR, T. R., BUDAK, S., İLBEY, Y. Ö., KÖSE, C., KAYA, Ö. Ö. (2016). Predictive factors for testicular sperm extraction (TESE) success in azoospermic cases with Klinefelter syndrome. Ege Tıp Dergisi, Cilt: 55 - Sayı: 2, 51–54. https://ajindex.com/articles/200148

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Klinefelter HF Jr, Reifenstein EC Jr, Albright F. Syndrome characterized by gynaecomastia, aspermatogenesis without aleydigism and increased excretion of follicle stimulating hormone. J Clin Endocrinol Metab 1942;2(11):615-27.
  2. Bojesen A, Juul S, Gravholt CH. Prenatal and postnatal prevalence of Klinefelter syndrome: A national registry study. J Clin Endocrinol Metab 2003;88(2):622-6.
  3. Tüttelmann F, Gromoll J. Novel genetic aspects of Klinefelter's syndrome. Mol Hum Reprod 2010;16(6):386-95. Mau-Holzmann UA. Somatic chromosomal abnormalities in infertile men and women. Cytogenet Genome Res 2005;111(3- 4):317-36.
  4. Aksglaede L, Wikström AM, Rajpert-De Meyts E, Dunkel L, Skakkebaek NE, Juul A. Natural history of seminiferous tubule degeneration in Klinefelter syndrome. Hum Reprod Update 2006;12(1):39-48.
  5. Tournaye H, Staessen C, Liebaers I, et al. Testicular sperm recovery in nine 47,XXY Klinefelter patients. Hum Reprod 1996;11(8):1644-9.
  6. Aksglaede L, Juul A. Testicular function and fertility in men with Klinefelter syndrome: A review. Eur J Endocrinol 2013;168(4):67-76.
  7. Yarali H, Polat M, Bozdag G, et al. TESE-ICSI in patients with non-mosaic Klinefelter syndrome: A comparative study. Reprod Biomed Online 2009;18(6):756-60.
  8. Bakircioglu ME, Ulug U, Erden HF, et al. Klinefelter syndrome: Does it confer a bad prognosis in treatment of nonobstructive azoospermia? Fertil Steril 2011;95(5):1696-9.
  9. Vernaeve V, Staessen C, Verheyen G, Van Steirteghem A, Devroey P, Tournaye H. Can biological or clinical parameters predict testicular sperm recovery in 47,XXY Klinefelter's syndrome patients? Hum Reprod 2004;19(5):1135-9.
  10. Bakircioglu ME, Erden HF, Kaplancan T, Ciray N, Bener F, Bahceci M. Aging may adversely affect testicular sperm recovery in patients with Klinefelter syndrome. Urology 2006;68(5):1082-6.
  11. Kyono K, Uto H, Nakajo Y, Kumagai S, Araki Y, Kanto S. Seven pregnancies and deliveries from non-mosaic Klinefelter syndrome patients using fresh and frozen testicular sperm. J Assist Reprod Genet 2007;24(1):47-51.
  12. Ramasamy R, Ricci JA, Palermo GD, Gosden LV, Rosenwaks Z, Schlegel PN. Successful fertility treatment for Klinefelter's syndrome. J Urol 2009;182(3):1108-13.
  13. Ferhi K, Avakian R, Griveau JF, Guille F. Age as only predictive factor for successful sperm recovery in patients with Klinefelter's syndrome. Andrologia 2009;41(2):84-7. World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th ed. WHO 2010.
  14. Jacobs PA, Hassold